3UD6
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![BU of 3ud6 by Molmil](/molmil-images/mine/3ud6) | Structural analyses of covalent enzyme-substrate analogue complexes reveal strengths and limitations of de novo enzyme design | 分子名称: | 1-(6-METHOXYNAPHTHALEN-2-YL)BUTANE-1,3-DIONE, RETRO-ALDOLASE, SULFATE ION | 著者 | Baker, D, Stoddard, B.L, Althoff, E.A, Wang, L, Jiang, L, Moody, J, Bolduc, J, Lassila, J, Hilvert, D. | 登録日 | 2011-10-27 | 公開日 | 2011-11-23 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.091 Å) | 主引用文献 | Structural analyses of covalent enzyme-substrate analog complexes reveal strengths and limitations of de novo enzyme design. J.Mol.Biol., 415, 2012
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5WP3
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![BU of 5wp3 by Molmil](/molmil-images/mine/5wp3) | Crystal Structure of EED in complex with EB22 | 分子名称: | EB22, Polycomb protein EED, UNKNOWN ATOM OR ION | 著者 | Dong, C, Tempel, W, Zhu, L, Moody, J.D, Baker, D, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2017-08-03 | 公開日 | 2017-09-13 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | First critical repressive H3K27me3 marks in embryonic stem cells identified using designed protein inhibitor. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6XSS
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![BU of 6xss by Molmil](/molmil-images/mine/6xss) | CryoEM structure of designed helical fusion protein C4_nat_HFuse-7900 | 分子名称: | C4_nat_HFuse-7900 | 著者 | Redler, R.L, Edman, N.I, Baker, D, Ekiert, D, Bhabha, G. | 登録日 | 2020-07-16 | 公開日 | 2020-12-23 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Design of multi-scale protein complexes by hierarchical building block fusion. Nat Commun, 12, 2021
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6XNS
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![BU of 6xns by Molmil](/molmil-images/mine/6xns) | C3_crown-05 | 分子名称: | C3_crown-05 | 著者 | Bick, M.J, Hsia, Y, Sankaran, B, Baker, D. | 登録日 | 2020-07-04 | 公開日 | 2020-12-23 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | 主引用文献 | Design of multi-scale protein complexes by hierarchical building block fusion. Nat Commun, 12, 2021
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6XT4
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6DMP
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![BU of 6dmp by Molmil](/molmil-images/mine/6dmp) | De Novo Design of a Protein Heterodimer with Specificity Mediated by Hydrogen Bond Networks | 分子名称: | Designed orthogonal protein DHD13_XAAA_A, Designed orthogonal protein DHD13_XAAA_B | 著者 | Chen, Z, Flores-Solis, D, Sgourakis, N.G, Baker, D. | 登録日 | 2018-06-05 | 公開日 | 2018-12-19 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Programmable design of orthogonal protein heterodimers. Nature, 565, 2019
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6M6Z
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![BU of 6m6z by Molmil](/molmil-images/mine/6m6z) | A de novo designed transmembrane nanopore, TMH4C4 | 分子名称: | TMH4C4 | 著者 | Lu, P, Xu, C, Reggiano, G, Xu, Q, DiMaio, F, Baker, D. | 登録日 | 2020-03-16 | 公開日 | 2020-06-24 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (5.9 Å) | 主引用文献 | Computational design of transmembrane pores. Nature, 585, 2020
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5IM5
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![BU of 5im5 by Molmil](/molmil-images/mine/5im5) | Crystal structure of designed two-component self-assembling icosahedral cage I53-40 | 分子名称: | Designed Keto-hydroxyglutarate-aldolase/keto-deoxy-phosphogluconate aldolase, Designed Riboflavin synthase | 著者 | Liu, Y.A, Cascio, D, Sawaya, M.R, Bale, J.B, Collazo, M.J, Thomas, C, Sheffler, W, King, N.P, Baker, D, Yeates, T.O. | 登録日 | 2016-03-05 | 公開日 | 2016-07-27 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.699 Å) | 主引用文献 | Accurate design of megadalton-scale two-component icosahedral protein complexes. Science, 353, 2016
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6E5C
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![BU of 6e5c by Molmil](/molmil-images/mine/6e5c) | Solution NMR structure of a de novo designed double-stranded beta-helix | 分子名称: | De novo beta protein | 著者 | Marcos, E, Chidyausiku, T.M, McShan, A, Evangelidis, T, Nerli, S, Sgourakis, N, Tripsianes, K, Baker, D. | 登録日 | 2018-07-19 | 公開日 | 2018-11-07 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | De novo design of a non-local beta-sheet protein with high stability and accuracy. Nat. Struct. Mol. Biol., 25, 2018
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5HS0
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![BU of 5hs0 by Molmil](/molmil-images/mine/5hs0) | Computationally Designed Cyclic Tetramer ank1C4_7 | 分子名称: | Ankyrin domain protein ank1C4_7, GLYCEROL, SULFATE ION | 著者 | McNamara, D.E, Cascio, D, Fallas, J.A, Baker, D, Yeates, T.O. | 登録日 | 2016-01-24 | 公開日 | 2017-04-12 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Computational design of self-assembling cyclic protein homo-oligomers. Nat Chem, 9, 2017
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5HRZ
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![BU of 5hrz by Molmil](/molmil-images/mine/5hrz) | Computationally Designed Trimer 1na0C3_3 | 分子名称: | TPR domain protein 1na0C3_3 | 著者 | Cascio, D, McNamara, D.E, Fallas, J.A, Baker, D, Yeates, T.O. | 登録日 | 2016-01-24 | 公開日 | 2017-04-12 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Computational design of self-assembling cyclic protein homo-oligomers. Nat Chem, 9, 2017
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7S5B
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1MOW
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![BU of 1mow by Molmil](/molmil-images/mine/1mow) | E-DreI | 分子名称: | 5'-D(*CP*CP*AP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*AP*GP*TP*TP*CP*CP*GP*GP*CP*G)-3', 5'-D(*CP*GP*CP*CP*GP*GP*AP*AP*CP*TP*TP*GP*AP*GP*AP*CP*AP*GP*TP*TP*TP*GP*G)-3', GLYCEROL, ... | 著者 | Chevalier, B.S, Kortemme, T, Chadsey, M.S, Baker, D, Monnat Jr, R.J, Stoddard, B.L. | 登録日 | 2002-09-10 | 公開日 | 2002-11-29 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Design, Activity and Structure of a Highly Specific Artificial Endonuclease Mol.Cell, 10, 2002
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1MPU
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![BU of 1mpu by Molmil](/molmil-images/mine/1mpu) | Crystal Structure of the free human NKG2D immunoreceptor | 分子名称: | NKG2-D type II integral membrane protein, PHOSPHATE ION | 著者 | McFarland, B.J, Kortemme, T, Baker, D, Strong, R.K. | 登録日 | 2002-09-12 | 公開日 | 2003-04-15 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Symmetry Recognizing Asymmetry: Analysis of the Interactions between the C-Type Lectin-like Immunoreceptor NKG2D and MHC
Class I-like Ligands Structure, 11, 2003
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4GMR
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![BU of 4gmr by Molmil](/molmil-images/mine/4gmr) | Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR266. | 分子名称: | NITRATE ION, OR266 DE NOVO PROTEIN | 著者 | Vorobiev, S, Su, M, Parmeggiani, F, Seetharaman, J, Huang, P.-S, Mao, M, Xiao, R, Lee, D, Everett, J.K, Acton, T.B, Baker, D, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2012-08-16 | 公開日 | 2012-08-29 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.377 Å) | 主引用文献 | Computational design of self-assembling cyclic protein homo-oligomers. NAT.CHEM., 9, 2017
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4GPM
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![BU of 4gpm by Molmil](/molmil-images/mine/4gpm) | Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR264. | 分子名称: | Engineered Protein OR264 | 著者 | Vorobiev, S, Su, M, Parmeggiani, F, Seetharaman, J, Huang, P.-S, Maglaqui, M, Xiao, R, Lee, D, Everett, J.K, Acton, T.B, Baker, D, Montelione, G.T, Tong, L, Hunt, J.F, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2012-08-21 | 公開日 | 2012-09-05 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.002 Å) | 主引用文献 | Computational design of self-assembling cyclic protein homo-oligomers. NAT.CHEM., 9, 2017
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6DG6
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![BU of 6dg6 by Molmil](/molmil-images/mine/6dg6) | Structure of a de novo designed Interleukin-2/Interleukin-15 mimetic | 分子名称: | Neoleukin-2/15 | 著者 | Jude, K.M, Silva, D.-A, Yu, S, Baker, D, Garcia, K.C. | 登録日 | 2018-05-16 | 公開日 | 2019-01-16 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.999 Å) | 主引用文献 | De novo design of potent and selective mimics of IL-2 and IL-15. Nature, 565, 2019
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4UOT
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![BU of 4uot by Molmil](/molmil-images/mine/4uot) | Thermodynamic hyperstability in parametrically designed helical bundles | 分子名称: | DESIGNED HELICAL BUNDLE 5H2L | 著者 | Oberdorfer, G, Huang, P, Pei, X.Y, Xu, C, Gonen, T, Nannenga, B, DiMaio, D, Rogers, J, Luisi, B.F, Baker, D. | 登録日 | 2014-06-09 | 公開日 | 2014-11-05 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | High Thermodynamic Stability of Parametrically Designed Helical Bundles Science, 346, 2014
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4UOS
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![BU of 4uos by Molmil](/molmil-images/mine/4uos) | Thermodynamic hyperstability in parametrically designed helical bundles | 分子名称: | DESIGNED HELICAL BUNDLE | 著者 | Oberdorfer, G, Huang, P, Pei, X.Y, Xu, C, Gonen, T, Nannenga, B, DiMaio, D, Rogers, J, Luisi, B.F, Baker, D. | 登録日 | 2014-06-09 | 公開日 | 2014-11-05 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | High Thermodynamic Stability of Parametrically Designed Helical Bundles Science, 346, 2014
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6E9R
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![BU of 6e9r by Molmil](/molmil-images/mine/6e9r) | DHF46 filament | 分子名称: | DHF46 filament | 著者 | Lynch, E.M, Shen, H, Fallas, J.A, Kollman, J.M, Baker, D. | 登録日 | 2018-08-01 | 公開日 | 2018-11-21 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (5.9 Å) | 主引用文献 | De novo design of self-assembling helical protein filaments. Science, 362, 2018
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6E9Z
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![BU of 6e9z by Molmil](/molmil-images/mine/6e9z) | DHF119 filament | 分子名称: | DHF119 filament | 著者 | Lynch, E.M, Shen, H, Fallas, J.A, Kollman, J.M, Baker, D. | 登録日 | 2018-08-01 | 公開日 | 2018-11-21 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | De novo design of self-assembling helical protein filaments. Science, 362, 2018
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4PQ8
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![BU of 4pq8 by Molmil](/molmil-images/mine/4pq8) | Crystal Structure of Engineered Protein, Northeast Structural Genomics Consortium Target OR465 | 分子名称: | CHLORIDE ION, DESIGNED PROTEIN OR465 | 著者 | Vorobiev, S, Parmeggiani, F, Seetharaman, J, Janjua, H, Xiao, R, Maglaqui, M, Park, K, Everett, J.K, Acton, T.B, Baker, D, Montelione, G.T, Tong, L, Hunt, J, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2014-02-28 | 公開日 | 2014-03-12 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.833 Å) | 主引用文献 | Crystal Structure of Engineered Protein OR465. To be Published
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4PSJ
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![BU of 4psj by Molmil](/molmil-images/mine/4psj) | Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium (NESG) Target OR464. | 分子名称: | OR464 | 著者 | Vorobiev, S, Parmeggiani, F, Seetharaman, J, Huang, P.-S, Janjua, H, Xiao, R, Maglaqui, M, Park, K, Everett, J.K, Acton, T.B, Baker, D, Montelione, G.T, Tong, L, Hunt, J, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2014-03-07 | 公開日 | 2014-03-26 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.992 Å) | 主引用文献 | Crystal Structure of Engineered Protein OR464. To be Published
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2GJ7
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![BU of 2gj7 by Molmil](/molmil-images/mine/2gj7) | Crystal Structure of a gE-gI/Fc complex | 分子名称: | Glycoprotein E, Ig gamma-1 chain C region, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | 著者 | Sprague, E.R, Wang, C, Baker, D, Bjorkman, P.J. | 登録日 | 2006-03-30 | 公開日 | 2006-05-30 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (5 Å) | 主引用文献 | Crystal Structure of the HSV-1 Fc Receptor Bound to Fc Reveals a Mechanism for Antibody Bipolar Bridging. Plos Biol., 4, 2006
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5A0E
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![BU of 5a0e by Molmil](/molmil-images/mine/5a0e) | Crystal structure of cyclophilin D in complex with CsA analogue, JW47. | 分子名称: | JW47, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE F, MITOCHONDRIAL | 著者 | Warne, J, Pryce, G, Hill, J, Shi, X, Lenneras, F, Puentes, F, Kip, M, Hilditch, L, Walker, P, Simone, M, Chan, A.W.E, Towers, G, Coker, A.R, Duchen, M, Szabadkai, G, Baker, D, Selwood, D.L. | 登録日 | 2015-04-19 | 公開日 | 2015-12-30 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects Against Neuro-Degeneration in Experimental Multiple Sclerosis. J.Biol.Chem., 291, 2016
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