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5XZE
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BU of 5xze by Molmil
Mouse cGAS bound to the inhibitor RU332
分子名称: (3R)-3-[1-(3H-1lambda~4~,3-benzothiazol-2-yl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl]-2-benzofuran-1(3H)-one, Cyclic GMP-AMP synthase, DNA (5'-D(*AP*AP*AP*TP*TP*GP*CP*CP*GP*AP*AP*GP*AP*CP*G)-3'), ...
著者Vincent, J, Adura, C, Gao, P, Luz, A, Lama, L, Asano, Y, Okamoto, R, Imaeda, T, Aida, J, Rothamel, K, Gogakos, T, Steinberg, J, Reasoner, S, Aso, K, Tuschl, T, Patel, D.J, Glickman, J.F, Ascano, M.
登録日2017-07-12
公開日2017-10-11
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.177 Å)
主引用文献Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.
Nat Commun, 8, 2017
5XZG
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BU of 5xzg by Molmil
Mouse cGAS bound to the inhibitor RU521
分子名称: 2-(4,5-dichloro-1H-benzimidazol-2-yl)-5-methyl-4-[(1R)-3-oxo-1,3-dihydro-2-benzofuran-1-yl]-1,2-dihydro-3H-pyrazol-3-one, Cyclic GMP-AMP synthase, DNA (5'-D(*AP*AP*AP*TP*TP*GP*CP*CP*GP*AP*AP*GP*AP*CP*G)-3'), ...
著者Vincent, J, Adura, C, Gao, P, Luz, A, Lama, L, Asano, Y, Okamoto, R, Imaeda, T, Aida, J, Rothamel, K, Gogakos, T, Steinberg, J, Reasoner, S, Aso, K, Tuschl, T, Patel, D.J, Glickman, J.F, Ascano, M.
登録日2017-07-12
公開日2017-10-11
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.828 Å)
主引用文献Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.
Nat Commun, 8, 2017
5XZB
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BU of 5xzb by Molmil
Mouse cGAS bound to the inhibitor RU365
分子名称: (3R)-3-[1-(1H-benzimidazol-2-yl)-5-hydroxy-3-methyl-1H-pyrazol-4-yl]-2-benzofuran-1(3H)-one, Cyclic GMP-AMP synthase, DNA (5'-D(*AP*AP*AP*TP*TP*GP*CP*CP*GP*AP*AP*GP*AP*CP*G)-3'), ...
著者Vincent, J, Adura, C, Gao, P, Luz, A, Lama, L, Asano, Y, Okamoto, R, Imaeda, T, Aida, J, Rothamel, K, Gogakos, T, Steinberg, J, Reasoner, S, Aso, K, Tuschl, T, Patel, D.J, Glickman, J.F, Ascano, M.
登録日2017-07-12
公開日2017-08-09
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.13 Å)
主引用文献Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice.
Nat Commun, 8, 2017
4K9A
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BU of 4k9a by Molmil
Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pG(2 ,5 )pA
分子名称: ADENOSINE MONOPHOSPHATE, Cyclic GMP-AMP synthase, DNA-F, ...
著者Gao, P, Wu, Y, Patel, D.J.
登録日2013-04-19
公開日2013-05-15
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.264 Å)
主引用文献Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.
Cell(Cambridge,Mass.), 153, 2013
4K97
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BU of 4k97 by Molmil
Structure of Ternary Complex of cGAS with dsDNA and Bound ATP
分子名称: ADENOSINE-5'-TRIPHOSPHATE, Cyclic GMP-AMP synthase, DNA-F, ...
著者Gao, P, Wu, Y, Patel, D.J.
登録日2013-04-19
公開日2013-05-15
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.
Cell(Cambridge,Mass.), 153, 2013
3RIU
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BU of 3riu by Molmil
Crystal structure of Drosophila hexameric C3PO formed by truncated Translin and Trax
分子名称: Translin, Translin associated factor X, isoform B
著者Tian, Y, Simanshu, D.K, Patel, D.J.
登録日2011-04-14
公開日2011-05-11
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Multimeric assembly and biochemical characterization of the Trax-translin endonuclease complex.
Nat.Struct.Mol.Biol., 18, 2011
4K8V
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BU of 4k8v by Molmil
Structure of cyclic GMP-AMP Synthase (cGAS)
分子名称: Cyclic GMP-AMP synthase, ZINC ION
著者Gao, P, Wu, Y, Patel, D.J.
登録日2013-04-18
公開日2013-05-15
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.
Cell(Cambridge,Mass.), 153, 2013
4QXR
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BU of 4qxr by Molmil
Crystal structure of hSTING(S162A/G230I/Q266I) in complex with DMXAA
分子名称: (5,6-dimethyl-9-oxo-9H-xanthen-4-yl)acetic acid, SULFATE ION, Stimulator of interferon genes protein
著者Gao, P, Patel, D.J.
登録日2014-07-21
公開日2014-09-10
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.37 Å)
主引用文献Binding-Pocket and Lid-Region Substitutions Render Human STING Sensitive to the Species-Specific Drug DMXAA.
Cell Rep, 8, 2014
4QXP
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BU of 4qxp by Molmil
Crystal structure of hSTING(G230I) in complex with DMXAA
分子名称: (5,6-dimethyl-9-oxo-9H-xanthen-4-yl)acetic acid, Stimulator of interferon genes protein
著者Gao, P, Patel, D.J.
登録日2014-07-21
公開日2014-09-10
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Binding-Pocket and Lid-Region Substitutions Render Human STING Sensitive to the Species-Specific Drug DMXAA.
Cell Rep, 8, 2014
4QXQ
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BU of 4qxq by Molmil
Crystal structure of hSTING(S162A/Q266I) in complex with DMXAA
分子名称: (5,6-dimethyl-9-oxo-9H-xanthen-4-yl)acetic acid, SULFATE ION, Stimulator of interferon genes protein
著者Gao, P, Patel, D.J.
登録日2014-07-21
公開日2014-09-10
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献Binding-Pocket and Lid-Region Substitutions Render Human STING Sensitive to the Species-Specific Drug DMXAA.
Cell Rep, 8, 2014
4QXO
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BU of 4qxo by Molmil
Crystal structure of hSTING(group2) in complex with DMXAA
分子名称: (5,6-dimethyl-9-oxo-9H-xanthen-4-yl)acetic acid, Stimulator of interferon genes protein
著者Gao, P, Patel, D.J.
登録日2014-07-21
公開日2014-09-10
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Binding-Pocket and Lid-Region Substitutions Render Human STING Sensitive to the Species-Specific Drug DMXAA.
Cell Rep, 8, 2014
4K9B
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BU of 4k9b by Molmil
Structure of Ternary Complex of cGAS with dsDNA and Bound c[G(2 ,5 )pA(3 ,5 )p]
分子名称: ADENOSINE MONOPHOSPHATE, Cyclic GMP-AMP synthase, DNA-F, ...
著者Gao, P, Wu, Y, Patel, D.J.
登録日2013-04-19
公開日2013-05-15
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.
Cell(Cambridge,Mass.), 153, 2013
4K96
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BU of 4k96 by Molmil
Structure of Binary Complex of cGAS with Bound dsDNA
分子名称: Cyclic GMP-AMP synthase, DNA-F, DNA-R, ...
著者Gao, P, Wu, Y, Patel, D.J.
登録日2013-04-19
公開日2013-05-15
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.084 Å)
主引用文献Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.
Cell(Cambridge,Mass.), 153, 2013
4KXT
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BU of 4kxt by Molmil
Structure of human ARGONAUTE1 in complex with guide RNA
分子名称: Protein argonaute-1, RNA
著者Nakanishi, K, Patel, D.J.
登録日2013-05-28
公開日2013-07-31
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.294 Å)
主引用文献Eukaryote-Specific Insertion Elements Control Human ARGONAUTE Slicer Activity.
Cell Rep, 3, 2013
4LOH
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BU of 4loh by Molmil
Crystal structure of hSTING(H232) in complex with c[G(2',5')pA(3',5')p]
分子名称: Stimulator of interferon genes protein, cGAMP
著者Gao, P, Patel, D.J.
登録日2013-07-12
公開日2013-08-14
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Structure-Function Analysis of STING Activation by c[G(2',5')pA(3',5')p] and Targeting by Antiviral DMXAA.
Cell(Cambridge,Mass.), 154, 2013
4LOJ
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BU of 4loj by Molmil
Crystal structure of mSting in complex with c[G(2',5')pA(3',5')p]
分子名称: Stimulator of interferon genes protein, cGAMP
著者Gao, P, Patel, D.J.
登録日2013-07-12
公開日2013-08-14
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Structure-Function Analysis of STING Activation by c[G(2',5')pA(3',5')p] and Targeting by Antiviral DMXAA.
Cell(Cambridge,Mass.), 154, 2013
4LOI
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BU of 4loi by Molmil
Crystal structure of hSTING(H232) in complex with c[G(2',5')pA(2',5')p]
分子名称: 2-amino-9-[(1R,3R,6R,8R,9R,11S,14R,16R,17R,18R)-16-(6-amino-9H-purin-9-yl)-3,11,17,18-tetrahydroxy-3,11-dioxido-2,4,7,10,12,15-hexaoxa-3,11-diphosphatricyclo[12.2.1.1~6,9~]octadec-8-yl]-1,9-dihydro-6H-purin-6-one, PHOSPHATE ION, Stimulator of interferon genes protein
著者Gao, P, Patel, D.J.
登録日2013-07-12
公開日2013-08-14
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Structure-Function Analysis of STING Activation by c[G(2',5')pA(3',5')p] and Targeting by Antiviral DMXAA.
Cell(Cambridge,Mass.), 154, 2013
4LOK
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BU of 4lok by Molmil
Crystal structure of mSting in complex with c[G(3',5')pA(3',5')p]
分子名称: 2-amino-9-[(2R,3R,3aR,5S,7aS,9R,10R,10aR,12R,14aS)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one, Stimulator of interferon genes protein
著者Gao, P, Patel, D.J.
登録日2013-07-12
公開日2013-08-14
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献Structure-Function Analysis of STING Activation by c[G(2',5')pA(3',5')p] and Targeting by Antiviral DMXAA.
Cell(Cambridge,Mass.), 154, 2013
4LOL
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BU of 4lol by Molmil
Crystal structure of mSting in complex with DMXAA
分子名称: (5,6-dimethyl-9-oxo-9H-xanthen-4-yl)acetic acid, Stimulator of interferon genes protein
著者Gao, P, Patel, D.J.
登録日2013-07-12
公開日2013-08-21
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.43 Å)
主引用文献Structure-Function Analysis of STING Activation by c[G(2',5')pA(3',5')p] and Targeting by Antiviral DMXAA.
Cell(Cambridge,Mass.), 154, 2013
4K98
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BU of 4k98 by Molmil
Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppG(2 ,5 )pG
分子名称: Cyclic GMP-AMP synthase, DNA-F, DNA-R, ...
著者Gao, P, Wu, Y, Patel, D.J.
登録日2013-04-19
公開日2013-05-15
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.
Cell(Cambridge,Mass.), 153, 2013
4K99
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BU of 4k99 by Molmil
Structure of Ternary Complex of cGAS with dsDNA and Bound 5 -pppdG(2 ,5 )pdG
分子名称: 3'-DEOXY-GUANOSINE-5'-TRIPHOSPHATE, 3'-deoxy-guanosine 5'-monophosphate, Cyclic GMP-AMP synthase, ...
著者Gao, P, Wu, Y, Patel, D.J.
登録日2013-04-19
公開日2013-05-15
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.
Cell(Cambridge,Mass.), 153, 2013

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