4LOK

Crystal structure of mSting in complex with c[G(3',5')pA(3',5')p]

Summary for 4LOK

• Entry DOI: 10.2210/pdb4lok/pdb
• Related: 4LOH 4LOI 4LOJ 4LOL
• Descriptor: Stimulator of interferon genes protein, 2-amino-9-[(2R,3R,3aR,5S,7aS,9R,10R,10aR,12R,14aS)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one (3 entities in total)
• Functional Keywords: innate immunity, immune system
• Biological source: Mus musculus (mouse)
• Cellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein: Q3TBT3
• Total number of polymer chains: 2
• Total formula weight: 43765.32

Authors

Gao, P.,Patel, D.J. (deposition date: 2013-07-12, release date: 2013-08-14, Last modification date: 2024-02-28)

• Primary citation: Gao, P.,Ascano, M.,Zillinger, T.,Wang, W.,Dai, P.,Serganov, A.A.,Gaffney, B.L.,Shuman, S.,Jones, R.A.,Deng, L.,Hartmann, G.,Barchet, W.,Tuschl, T.,Patel, D.J.; Structure-Function Analysis of STING Activation by c[G(2',5')pA(3',5')p] and Targeting by Antiviral DMXAA.; Cell(Cambridge,Mass.), 154:748-762, 2013; PubMed: 23910378; DOI: 10.1016/j.cell.2013.07.023

Experimental method

X-RAY DIFFRACTION (2.07 Å)