4LOL

Crystal structure of mSting in complex with DMXAA

Summary for 4LOL

• Entry DOI: 10.2210/pdb4lol/pdb
• Related: 4LOH 4LOI 4LOJ 4LOK
• Descriptor: Stimulator of interferon genes protein, (5,6-dimethyl-9-oxo-9H-xanthen-4-yl)acetic acid (3 entities in total)
• Functional Keywords: innate immunity, immune system
• Biological source: Mus musculus (mouse)
• Cellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein: Q3TBT3
• Total number of polymer chains: 2
• Total formula weight: 43655.50

Authors

Gao, P.,Patel, D.J. (deposition date: 2013-07-12, release date: 2013-08-21, Last modification date: 2024-02-28)

• Primary citation: Gao, P.,Ascano, M.,Zillinger, T.,Wang, W.,Dai, P.,Serganov, A.A.,Gaffney, B.L.,Shuman, S.,Jones, R.A.,Deng, L.,Hartmann, G.,Barchet, W.,Tuschl, T.,Patel, D.J.; Structure-Function Analysis of STING Activation by c[G(2',5')pA(3',5')p] and Targeting by Antiviral DMXAA.; Cell(Cambridge,Mass.), 154:748-762, 2013; PubMed: 23910378; DOI: 10.1016/j.cell.2013.07.023

Experimental method

X-RAY DIFFRACTION (2.43 Å)