4LOK
Crystal structure of mSting in complex with c[G(3',5')pA(3',5')p]
Summary for 4LOK
Entry DOI | 10.2210/pdb4lok/pdb |
Related | 4LOH 4LOI 4LOJ 4LOL |
Descriptor | Stimulator of interferon genes protein, 2-amino-9-[(2R,3R,3aR,5S,7aS,9R,10R,10aR,12R,14aS)-9-(6-amino-9H-purin-9-yl)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecin-2-yl]-1,9-dihydro-6H-purin-6-one (3 entities in total) |
Functional Keywords | innate immunity, immune system |
Biological source | Mus musculus (mouse) |
Cellular location | Endoplasmic reticulum membrane; Multi-pass membrane protein: Q3TBT3 |
Total number of polymer chains | 2 |
Total formula weight | 43765.32 |
Authors | Gao, P.,Patel, D.J. (deposition date: 2013-07-12, release date: 2013-08-14, Last modification date: 2024-02-28) |
Primary citation | Gao, P.,Ascano, M.,Zillinger, T.,Wang, W.,Dai, P.,Serganov, A.A.,Gaffney, B.L.,Shuman, S.,Jones, R.A.,Deng, L.,Hartmann, G.,Barchet, W.,Tuschl, T.,Patel, D.J. Structure-Function Analysis of STING Activation by c[G(2',5')pA(3',5')p] and Targeting by Antiviral DMXAA. Cell(Cambridge,Mass.), 154:748-762, 2013 Cited by PubMed: 23910378DOI: 10.1016/j.cell.2013.07.023 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.07 Å) |
Structure validation
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