Crystal structure of hSTING(G230I) in complex with DMXAA

Summary for 4QXP

Related4QXO 4QXQ 4QXR
DescriptorStimulator of interferon genes protein, (5,6-dimethyl-9-oxo-9H-xanthen-4-yl)acetic acid (3 entities in total)
Functional Keywordsimmune system, innate immunity, cgamp binding, membrane
Biological sourceHomo sapiens (human)
Cellular locationEndoplasmic reticulum membrane; Multi-pass membrane protein Q86WV6
Total number of polymer chains2
Total molecular weight43763.2
Gao, P.,Patel, D.J. (deposition date: 2014-07-21, release date: 2014-09-10, Last modification date: 2014-10-08)
Primary citation
Gao, P.,Zillinger, T.,Wang, W.,Ascano, M.,Dai, P.,Hartmann, G.,Tuschl, T.,Deng, L.,Barchet, W.,Patel, D.J.
Binding-Pocket and Lid-Region Substitutions Render Human STING Sensitive to the Species-Specific Drug DMXAA.
Cell Rep, 8:1668-1676, 2014
PubMed: 25199835 (PDB entries with the same primary citation)
DOI: 10.1016/j.celrep.2014.08.010
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.234220.3%15.4%5.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload