4LOI

Crystal structure of hSTING(H232) in complex with c[G(2',5')pA(2',5')p]

Summary for 4LOI

• Entry DOI: 10.2210/pdb4loi/pdb
• Related: 4LOH 4LOJ 4LOK 4LOL
• Descriptor: Stimulator of interferon genes protein, PHOSPHATE ION, 2-amino-9-[(1R,3R,6R,8R,9R,11S,14R,16R,17R,18R)-16-(6-amino-9H-purin-9-yl)-3,11,17,18-tetrahydroxy-3,11-dioxido-2,4,7,10,12,15-hexaoxa-3,11-diphosphatricyclo[12.2.1.1~6,9~]octadec-8-yl]-1,9-dihydro-6H-purin-6-one, ... (4 entities in total)
• Functional Keywords: innate immunity, immune system
• Biological source: Homo sapiens (human)
• Cellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein: Q86WV6
• Total number of polymer chains: 2
• Total formula weight: 43817.70

Authors

Gao, P.,Patel, D.J. (deposition date: 2013-07-12, release date: 2013-08-14, Last modification date: 2024-02-28)

• Primary citation: Gao, P.,Ascano, M.,Zillinger, T.,Wang, W.,Dai, P.,Serganov, A.A.,Gaffney, B.L.,Shuman, S.,Jones, R.A.,Deng, L.,Hartmann, G.,Barchet, W.,Tuschl, T.,Patel, D.J.; Structure-Function Analysis of STING Activation by c[G(2',5')pA(3',5')p] and Targeting by Antiviral DMXAA.; Cell(Cambridge,Mass.), 154:748-762, 2013; PubMed: 23910378; DOI: 10.1016/j.cell.2013.07.023

Experimental method

X-RAY DIFFRACTION (1.89 Å)