1WO1
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1WO0
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4BWS
| Crystal structure of the heterotrimer of PQBP1, U5-15kD and U5-52kD. | 分子名称: | CD2 ANTIGEN CYTOPLASMIC TAIL-BINDING PROTEIN 2, POLYGLUTAMINE-BINDING PROTEIN 1, THIOREDOXIN-LIKE PROTEIN 4A | 著者 | Mizuguchi, M, Obita, T, Serita, T, Kojima, R, Morimoto, T, Nabeshima, Y, Okazawa, H. | 登録日 | 2013-07-04 | 公開日 | 2014-04-30 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Mutations in the Pqbp1 Gene Prevent its Interaction with the Spliceosomal Protein U5-15Kd. Nat.Commun., 5, 2014
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4CDO
| Crystal structure of PQBP1 bound to spliceosomal U5-15kD | 分子名称: | THIOREDOXIN-LIKE PROTEIN 4A, POLYGLUTAMINE-BINDING PROTEIN | 著者 | Mizuguchi, M, Obita, T, Serita, T, Kojima, R, Nabeshima, Y, Okazawa, H. | 登録日 | 2013-11-05 | 公開日 | 2014-04-30 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Mutations in the Pqbp1 Gene Prevent its Interaction with the Spliceosomal Protein U5-15Kd. Nat.Commun., 5, 2014
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4BWQ
| Crystal structure of U5-15kD in a complex with PQBP1 | 分子名称: | POLYGLUTAMINE-BINDING PROTEIN 1, THIOREDOXIN-LIKE PROTEIN 4A | 著者 | Mizuguchi, M, Obita, T, Serita, T, Kojima, R, Morimoto, T, Nabeshima, Y, Okazawa, H. | 登録日 | 2013-07-04 | 公開日 | 2014-04-30 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Mutations in the Pqbp1 Gene Prevent its Interaction with the Spliceosomal Protein U5-15Kd. Nat.Commun., 5, 2014
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8JOK
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8JNU
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8JQW
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7W9Q
| Crystal structure of V30M-TTR in complex with naringenin derivative-14 | 分子名称: | (2~{R})-2-(3-chloranyl-4-oxidanyl-phenyl)-5,7-bis(oxidanyl)-2,3-dihydrochromen-4-one, CALCIUM ION, Transthyretin | 著者 | Katayama, W, Shimane, A, Nabeshima, Y, Yokoyama, T, Mizuguchi, M. | 登録日 | 2021-12-10 | 公開日 | 2022-12-14 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.599 Å) | 主引用文献 | Chlorinated Naringenin Analogues as Potential Inhibitors of Transthyretin Amyloidogenesis. J.Med.Chem., 65, 2022
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7W9R
| Crystal structure of V30M-TTR in complex with naringenin derivative-18 | 分子名称: | (2~{R})-2-[3,5-bis(chloranyl)-4-oxidanyl-phenyl]-5,7-bis(oxidanyl)-2,3-dihydrochromen-4-one, Transthyretin | 著者 | Katayama, W, Shimane, A, Nabeshima, Y, Yokoyama, T, Mizuguchi, M. | 登録日 | 2021-12-10 | 公開日 | 2022-12-14 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.997 Å) | 主引用文献 | Chlorinated Naringenin Analogues as Potential Inhibitors of Transthyretin Amyloidogenesis. J.Med.Chem., 65, 2022
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8I76
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8I75
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8I74
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1WRU
| Structure of central hub elucidated by X-ray analysis of gene product 44; baseplate component of bacteriophage Mu | 分子名称: | 43 kDa tail protein | 著者 | Kondou, Y, Kitazawa, D, Takeda, S, Yamashita, E, Mizuguchi, M, Kawano, K, Tsukihara, T. | 登録日 | 2004-10-27 | 公開日 | 2005-09-20 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure of central hub elucidated by X-ray analysis of gene product 44; baseplate component of bacteriophage Mu To be Published
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4N87
| Crystal structure of V30M mutant human transthyretin complexed with glabridin | 分子名称: | 4-[(3R)-8,8-dimethyl-3,4-dihydro-2H,8H-pyrano[2,3-f]chromen-3-yl]benzene-1,3-diol, Transthyretin | 著者 | Yokoyama, T, Kosaka, Y, Mizuguchi, M. | 登録日 | 2013-10-17 | 公開日 | 2014-02-19 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.794 Å) | 主引用文献 | Crystal structures of human transthyretin complexed with glabridin J.Med.Chem., 57, 2014
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4N85
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4N86
| Crystal structure of human transthyretin complexed with glabridin | 分子名称: | 4-[(3R)-8,8-dimethyl-3,4-dihydro-2H,8H-pyrano[2,3-f]chromen-3-yl]benzene-1,3-diol, CALCIUM ION, Transthyretin | 著者 | Yokoyama, T, Kosaka, Y, Mizuguchi, M. | 登録日 | 2013-10-17 | 公開日 | 2014-02-19 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.001 Å) | 主引用文献 | Crystal structures of human transthyretin complexed with glabridin J.Med.Chem., 57, 2014
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2MDB
| Tachyplesin I in the presence of lipopolysaccharide | 分子名称: | Tachyplesin-1 | 著者 | Kushibiki, T, Kamiya, M, Aizawa, T, Kumaki, Y, Kikukawa, T, Mizuguchi, M, Demura, M, Kawabata, S.I, Kawano, K. | 登録日 | 2013-09-09 | 公開日 | 2014-02-19 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Interaction between tachyplesin I, an antimicrobial peptide derived from horseshoe crab, and lipopolysaccharide. Biochim.Biophys.Acta, 1844, 2014
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5X2L
| Crystal Structure of Human Serine Racemase | 分子名称: | MAGNESIUM ION, PYRIDOXAL-5'-PHOSPHATE, Serine racemase | 著者 | Obita, T, Matsumoto, K, Mori, H, Toyooka, N, Mizuguchi, M. | 登録日 | 2017-02-01 | 公開日 | 2018-01-31 | 最終更新日 | 2021-02-24 | 実験手法 | X-RAY DIFFRACTION (1.806 Å) | 主引用文献 | Design, synthesis, and evaluation of novel inhibitors for wild-type human serine racemase. Bioorg. Med. Chem. Lett., 2017
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7WL6
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2RTV
| Tachyplesin I in water | 分子名称: | Tachyplesin-1 | 著者 | Kushibiki, T, Kamiya, M, Aizawa, T, Kumaki, Y, Kikukawa, T, Mizuguchi, M, Demura, M, Kawabata, S.I, Kawano, K. | 登録日 | 2013-09-19 | 公開日 | 2014-02-19 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Interaction between tachyplesin I, an antimicrobial peptide derived from horseshoe crab, and lipopolysaccharide. Biochim.Biophys.Acta, 1844, 2014
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2RNG
| Solution structure of big defensin | 分子名称: | Big defensin | 著者 | Kouno, T, Fujitani, N, Osaki, T, Kawabata, S, Nishimura, S, Mizuguchi, M, Aizawa, T, Demura, M, Nitta, K, Kawano, K. | 登録日 | 2007-12-27 | 公開日 | 2008-10-14 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | A novel beta-defensin structure: a potential strategy of big defensin for overcoming resistance by Gram-positive bacteria Biochemistry, 47, 2008
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2RQ2
| The solution structure of the N-terminal fragment of big defensin | 分子名称: | Big defensin | 著者 | Kouno, T, Mizuguchi, M, Aizawa, T, Shinoda, H, Demura, M, Kawabata, S, Kawano, K. | 登録日 | 2009-01-07 | 公開日 | 2009-08-25 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | A novel beta-defensin structure: big defensin changes its N-terminal structure to associate with the target membrane Biochemistry, 48, 2009
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5AON
| Crystal structure of the conserved N-terminal domain of Pex14 from Trypanosoma brucei | 分子名称: | PEROXIN 14, SULFATE ION | 著者 | Obita, T, Sugawara, Y, Mizuguchi, M, Watanabe, Y, Kawaguchi, K, Imanaka, T. | 登録日 | 2015-09-11 | 公開日 | 2015-12-23 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.646 Å) | 主引用文献 | Characterization of the Interaction between Trypanosoma Brucei Pex5P and its Receptor Pex14P. FEBS Lett., 590, 2016
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6AA4
| Crystal structure of MTH1 in complex with alpha-mangostin (cocktail No. 9) | 分子名称: | 1,3,6-trihydroxy-7-methoxy-2,8-bis(3-methylbut-2-en-1-yl)-9H-xanthen-9-one, 7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION, ... | 著者 | Yokoyama, T, Kitakami, R, Mizuguchi, M. | 登録日 | 2018-07-17 | 公開日 | 2019-03-06 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discovery of a new class of MTH1 inhibitor by X-ray crystallographic screening. Eur J Med Chem, 167, 2019
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