8RFB
 
 | | Cryo-EM structure of the R243C mutant of human Prolyl Endopeptidase-Like (PREPL) protein involved in Congenital myasthenic syndrome-22 (CMS22) | | 分子名称: | Prolyl endopeptidase-like | | 著者 | Theodoropoulou, A, Cavani, E, Antanasijevic, A, Marcaida, M.J, Dal Peraro, M. | | 登録日 | 2023-12-12 | | 公開日 | 2024-09-04 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (4.01 Å) | | 主引用文献 | Missense variants in CMS22 patients reveal that PREPL has both enzymatic and nonenzymatic functions.
JCI Insight, 9, 2024
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2HZ8
 | | QM/MM structure refined from NMR-structure of a single chain diiron protein | | 分子名称: | De novo designed diiron protein, ZINC ION | | 著者 | Calhoun, J.R, Liu, W, Spiegel, K, Dal Peraro, M, Klein, M.L, Wand, A.J, DeGrado, W.F. | | 登録日 | 2006-08-08 | | 公開日 | 2007-07-17 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution NMR structure of a designed metalloprotein and complementary molecular dynamics refinement.
Structure, 16, 2008
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6QGS
 | | Crystal structure of APT1 bound to palmitic acid. | | 分子名称: | Acyl-protein thioesterase 1, CHLORIDE ION, PALMITIC ACID | | 著者 | Audagnotto, M, Marcaida, M.J, Ho, S, Pojer, F, Van der Goot, G, Dal Peraro, M. | | 登録日 | 2019-01-12 | | 公開日 | 2020-02-05 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.755 Å) | | 主引用文献 | Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains.
Nat.Chem.Biol., 2021
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6QGQ
 | | Crystal structure of APT1 C2S mutant bound to palmitic acid. | | 分子名称: | Acyl-protein thioesterase 1, GLYCEROL, PALMITIC ACID | | 著者 | Audagnotto, M, Marcaida, M.J, Ho, S, Pojer, F, Van der Goot, G, Dal Peraro, M. | | 登録日 | 2019-01-12 | | 公開日 | 2020-02-05 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.601 Å) | | 主引用文献 | Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains.
Nat.Chem.Biol., 2021
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6QGN
 | | Crystal structure of APT1 bound to 2-Bromopalmitate | | 分子名称: | 2-Bromopalmitic acid, Acyl-protein thioesterase 1 | | 著者 | Marcaida, M.J, Audagnotto, M, Ho, S, Pojer, F, Van der Goot, G, Dal Peraro, M. | | 登録日 | 2019-01-12 | | 公開日 | 2020-02-05 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.099 Å) | | 主引用文献 | Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains.
Nat.Chem.Biol., 2021
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6QGO
 | | Crystal structure of APT1 S119A mutant bound to palmitic acid. | | 分子名称: | Acyl-protein thioesterase 1, PALMITIC ACID | | 著者 | Audagnotto, M, Marcaida, M.J, Ho, S, Pojer, F, Van der Goot, G, Dal Peraro, M. | | 登録日 | 2019-01-12 | | 公開日 | 2020-02-05 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.599 Å) | | 主引用文献 | Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains.
Nat.Chem.Biol., 2021
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9FNQ
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9FM6
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9FNP
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5JZH
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7OBM
 | | Crystal structure of the human Prolyl Endopeptidase-Like protein short form (residues 90-727) | | 分子名称: | Prolyl endopeptidase-like | | 著者 | Rosier, K, McDevitt, M.T, Brendan, J.F, Marcaida, M.J, Bingman, C.A, Pagliarini, D.J, Creemers, J.W.M, Smith, R.W, Mitochondrial Protein Partnership (MPP) | | 登録日 | 2021-04-22 | | 公開日 | 2021-11-10 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Prolyl endopeptidase-like is a (thio)esterase involved in mitochondrial respiratory chain function.
Iscience, 24, 2021
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7SSP
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7SSS
 | | Structure of the NADH-bound human COQ7:COQ9 complex by single-particle electron cryo-microscopy | | 分子名称: | (1S)-2-{[(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL STEARATE, 2-[(2E,6E,10E,14E,18E,22E,26E)-3,7,11,15,19,23,27,31-OCTAMETHYLDOTRIACONTA-2,6,10,14,18,22,26,30-OCTAENYL]PHENOL, 5-demethoxyubiquinone hydroxylase, ... | | 著者 | Aydin, H, Frost, A. | | 登録日 | 2021-11-11 | | 公開日 | 2022-11-02 | | 最終更新日 | 2025-05-21 | | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | | 主引用文献 | Structure and functionality of a multimeric human COQ7:COQ9 complex.
Mol.Cell, 82, 2022
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5I35
 | | Structure of the Human mitochondrial kinase COQ8A R611K with AMPPNP (Cerebellar Ataxia and Ubiquinone Deficiency Through Loss of Unorthodox Kinase Activity) | | 分子名称: | Atypical kinase ADCK3, mitochondrial, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | 著者 | Bingman, C.A, Stefely, J.A, Pagliarini, D.J, Mitochondrial Protein Partnership (MPP) | | 登録日 | 2016-02-09 | | 公開日 | 2016-08-17 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Cerebellar Ataxia and Coenzyme Q Deficiency through Loss of Unorthodox Kinase Activity.
Mol.Cell, 63, 2016
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3G4O
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3G4N
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6DEW
 | | Structure of human COQ9 protein with bound isoprene. | | 分子名称: | (2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol, (2Z,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol, (2Z,6Z)-3,7,11-trimethyldodeca-2,6,10-trien-1-ol, ... | | 著者 | Bingman, C.A, Lohman, D.C, Smith, R.W, Pagliarini, D.J. | | 登録日 | 2018-05-13 | | 公開日 | 2019-02-06 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | An Isoprene Lipid-Binding Protein Promotes Eukaryotic Coenzyme Q Biosynthesis.
Mol.Cell, 73, 2019
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6HX0
 | | Cell wall binding domain of endolysin from Listeria phage A500. | | 分子名称: | L-alanyl-D-glutamate peptidase | | 著者 | Dunne, M, Taylor, N.M.I, Shen, Y, Loessner, M.J, Leiman, P.G. | | 登録日 | 2018-10-15 | | 公開日 | 2019-10-30 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | | 主引用文献 | Structural basis for recognition of bacterial cell wall teichoic acid by pseudo-symmetric SH3b-like repeats of a viral peptidoglycan hydrolase
Chem Sci, 2020
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6HTF
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6AWL
 | | Crystal structure of human Coq9 | | 分子名称: | 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE, Ubiquinone biosynthesis protein COQ9, ... | | 著者 | Bingman, C.A, Lohman, D.C, Smith, R.W, Pagliarini, D.J, Mitochondrial Protein Partnership (MPP) | | 登録日 | 2017-09-05 | | 公開日 | 2019-02-06 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | An Isoprene Lipid-Binding Protein Promotes Eukaryotic Coenzyme Q Biosynthesis.
Mol. Cell, 73, 2019
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9CEA
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9CDW
 | | Crystal structure of HP1alpha chromoshadow domain in complex with KAP1 peptide | | 分子名称: | Chromobox protein homolog 5, TRIETHYLENE GLYCOL, Transcription intermediary factor 1-beta peptide | | 著者 | Selvam, K, Singh, R.K, Gaurav, N, Kutateladze, T.G. | | 登録日 | 2024-06-25 | | 公開日 | 2025-06-11 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | The HP1 box of KAP1 organizes HP1 alpha for silencing of endogenous retroviral elements in embryonic stem cells.
Nat Commun, 16, 2025
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8PBV
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3C0N
 | | Crystal structure of the proaerolysin mutant Y221G at 2.2 A | | 分子名称: | Aerolysin | | 著者 | Pernot, L, Schiltz, M, Thurnheer, S, Burr, S.E, van der Goot, G. | | 登録日 | 2008-01-21 | | 公開日 | 2008-02-12 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Molecular assembly of the aerolysin pore reveals a swirling membrane-insertion mechanism.
Nat.Chem.Biol., 9, 2013
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3C0O
 | | Crystal structure of the proaerolysin mutant Y221G complexed with mannose-6-phosphate | | 分子名称: | 6-O-phosphono-alpha-D-mannopyranose, ACETATE ION, Aerolysin | | 著者 | Pernot, L, Schiltz, M, Thurnheer, S, Burr, S.E, van der Goot, G. | | 登録日 | 2008-01-21 | | 公開日 | 2008-02-12 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Molecular assembly of the aerolysin pore reveals a swirling membrane-insertion mechanism.
Nat.Chem.Biol., 9, 2013
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