5IBM
| Structure of S502P, a Cancer-Associated Mutation of the Oncogenic Phosphatase SHP2 | 分子名称: | Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Blacklow, S.C, Stams, T, Fodor, M, LaRochelle, J.R. | 登録日 | 2016-02-22 | 公開日 | 2016-04-13 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | 主引用文献 | Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2. Biochemistry, 55, 2016
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5IBS
| Structure of E76Q, a Cancer-Associated Mutation of the Oncogenic Phosphatase SHP2 | 分子名称: | Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Blacklow, S.C, Stams, T, Fodor, M, LaRochelle, J.R. | 登録日 | 2016-02-22 | 公開日 | 2016-04-13 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.32 Å) | 主引用文献 | Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase SHP2. Biochemistry, 55, 2016
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6BN5
| Non-receptor Protein Tyrosine Phosphatase SHP2 F285S in Complex with Allosteric Inhibitor JLR-2 | 分子名称: | 3-benzyl-8-chloro-2-hydroxy-4H-pyrimido[2,1-b][1,3]benzothiazol-4-one, Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Blacklow, S.C, Stams, T, Fodor, M, LaRochelle, J.R. | 登録日 | 2017-11-16 | 公開日 | 2017-12-13 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.22 Å) | 主引用文献 | Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2. Bioorg. Med. Chem., 25, 2017
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1D2J
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5HQG
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1AJJ
| LDL RECEPTOR LIGAND-BINDING MODULE 5, CALCIUM-COORDINATING | 分子名称: | CALCIUM ION, LOW-DENSITY LIPOPROTEIN RECEPTOR, SULFATE ION | 著者 | Fass, D, Blacklow, S.C, Kim, P.S, Berger, J.M. | 登録日 | 1997-05-04 | 公開日 | 1997-07-07 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module. Nature, 388, 1997
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8V0E
| ANK repeat of MIB1 | 分子名称: | E3 ubiquitin-protein ligase MIB1, Unidentified MIB1 peptide | 著者 | Cao, R, Blacklow, S.C. | 登録日 | 2023-11-17 | 公開日 | 2024-09-25 | 最終更新日 | 2024-10-16 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Structural requirements for activity of Mind bomb1 in Notch signaling. Structure, 32, 2024
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8ESV
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6PY8
| Crystal structure of the RBPJ-NOTCH1-NRARP ternary complex bound to DNA | 分子名称: | DNA, Neurogenic locus notch homolog protein 1, Notch-regulated ankyrin repeat-containing protein, ... | 著者 | Jarrett, S.M, Seegar, T.C.M, Blacklow, S.C. | 登録日 | 2019-07-29 | 公開日 | 2019-08-14 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.75 Å) | 主引用文献 | Extension of the Notch intracellular domain ankyrin repeat stack by NRARP promotes feedback inhibition of Notch signaling. Sci.Signal., 12, 2019
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7JIC
| Structure of human CD19-CD81 co-receptor complex bound to coltuximab Fab fragment | 分子名称: | B-lymphocyte antigen CD19, CD81 antigen, Coltuximab Heavy Chain, ... | 著者 | Susa, K.J, Rawson, S, Kruse, A.C, Blacklow, S.C. | 登録日 | 2020-07-23 | 公開日 | 2021-01-20 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Cryo-EM structure of the B cell co-receptor CD19 bound to the tetraspanin CD81 Science, 371, 2021
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3NBN
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3I08
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7RDB
| Crystal structure of Tspan15 large extracellular loop (Tspan15 LEL) | 分子名称: | Tetraspanin-15 | 著者 | Lipper, C.H, Gabriel, K.H, Seegar, T.C.M, Durr, K.L, Tomlinson, M.G, Blacklow, S.C. | 登録日 | 2021-07-09 | 公開日 | 2021-11-03 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.52 Å) | 主引用文献 | Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site. Structure, 30, 2022
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7RD5
| Crystal structure of Tspan15 large extracellular loop (Tspan15 LEL) in complex with 1C12 Fab | 分子名称: | 1C12 Fab Heavy Chain, 1C12 Fab Light Chain, Tetraspanin-15 | 著者 | Lipper, C.H, Gabriel, K.H, Seegar, T.C.M, Durr, K.L, Tomlinson, M.G, Blacklow, S.C. | 登録日 | 2021-07-09 | 公開日 | 2021-11-03 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | Crystal structure of the Tspan15 LEL domain reveals a conserved ADAM10 binding site. Structure, 30, 2022
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6NCM
| Crystal structure of the human FOXN3 DNA binding domain in complex with a forkhead-like (FHL) DNA sequence | 分子名称: | DNA (5'-D(*AP*TP*AP*GP*CP*GP*TP*CP*TP*TP*AP*GP*CP*AP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*TP*GP*CP*TP*AP*AP*GP*AP*CP*GP*CP*TP*A)-3'), Forkhead box protein N3, ... | 著者 | Rogers, J.M, Jarrett, S.M, Seegar, T.C, Waters, C.T, Hallworth, A.N, Blacklow, S.C, Bulyk, M.L. | 登録日 | 2018-12-11 | 公開日 | 2019-02-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.704 Å) | 主引用文献 | Bispecific Forkhead Transcription Factor FoxN3 Recognizes Two Distinct Motifs with Different DNA Shapes. Mol. Cell, 74, 2019
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6NCE
| Crystal structure of the human FOXN3 DNA binding domain in complex with a forkhead DNA sequence | 分子名称: | DNA (5'-D(*AP*CP*AP*TP*TP*GP*TP*TP*TP*AP*CP*TP*TP*AP*AP*G)-3'), DNA (5'-D(*TP*CP*TP*TP*AP*AP*GP*TP*AP*AP*AP*CP*AP*AP*TP*G)-3'), Forkhead box protein N3, ... | 著者 | Rogers, J.M, Jarrett, S.M, Seegar, T.C, Waters, C.T, Hallworth, A.N, Blacklow, S.C, Bulyk, M.L. | 登録日 | 2018-12-11 | 公開日 | 2019-02-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.598 Å) | 主引用文献 | Bispecific Forkhead Transcription Factor FoxN3 Recognizes Two Distinct Motifs with Different DNA Shapes. Mol. Cell, 74, 2019
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6U9S
| Crystal structure of human CD81 large extracellular loop in complex with 5A6 Fab | 分子名称: | 5A6 FAB Heavy Chain, 5A6 FAB Light Chain, CD81 antigen, ... | 著者 | Susa, K.J, Seegar, T.C.M, Blacklow, S.C.B, Kruse, A.C. | 登録日 | 2019-09-09 | 公開日 | 2020-05-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | A dynamic interaction between CD19 and the tetraspanin CD81 controls B cell co-receptor trafficking. Elife, 9, 2020
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2F8X
| Crystal structure of activated Notch, CSL and MAML on HES-1 promoter DNA sequence | 分子名称: | 5'-D(*GP*TP*TP*AP*CP*TP*GP*TP*GP*GP*GP*AP*AP*AP*GP*AP*AP*A)-3', 5'-D(*TP*TP*TP*CP*TP*TP*TP*CP*CP*CP*AP*CP*AP*GP*TP*AP*AP*C)-3', Mastermind-like protein 1, ... | 著者 | Nam, Y, Sliz, P, Blacklow, S.C. | 登録日 | 2005-12-04 | 公開日 | 2006-04-04 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (3.25 Å) | 主引用文献 | Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell(Cambridge,Mass.), 124, 2006
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2FCW
| Structure of a Complex Between the Pair of the LDL Receptor Ligand-Binding Modules 3-4 and the Receptor Associated Protein (RAP). | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Alpha-2-macroglobulin receptor-associated protein, CALCIUM ION, ... | 著者 | Beglova, N, Fisher, C, Blacklow, S.C. | 登録日 | 2005-12-12 | 公開日 | 2006-05-16 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.26 Å) | 主引用文献 | Structure of an LDLR-RAP Complex Reveals a General Mode for Ligand Recognition by Lipoprotein Receptors Mol.Cell, 22, 2006
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2F8Y
| Crystal structure of human Notch1 ankyrin repeats to 1.55A resolution. | 分子名称: | Notch homolog 1, translocation-associated (Drosophila), SULFATE ION | 著者 | Nam, Y, Sliz, P, Blacklow, S.C. | 登録日 | 2005-12-04 | 公開日 | 2006-04-04 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes. Cell(Cambridge,Mass.), 124, 2006
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5IGQ
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5I6V
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5J45
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5IGO
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5L2Q
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