8DS5
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![BU of 8ds5 by Molmil](/molmil-images/mine/8ds5) | X-ray structure of the MK5890 Fab - CD27 antibody-antigen complex | 分子名称: | CADMIUM ION, CD27 antigen, MK-5890 Fab heavy chain, ... | 著者 | Fischmann, T.O. | 登録日 | 2022-07-21 | 公開日 | 2022-09-28 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.926 Å) | 主引用文献 | Preclinical characterization and clinical translation of pharmacodynamic markers for MK-5890: a human CD27 activating antibody for cancer immunotherapy. J Immunother Cancer, 10, 2022
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8DTX
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![BU of 8dtx by Molmil](/molmil-images/mine/8dtx) | Crystal structure of SARS-CoV-2 spike stem helix peptide in complex with neutralizing antibody COV89-22 | 分子名称: | COV89-22 heavy chain, COV89-22 light chain, Spike protein S2' stem helix peptide | 著者 | Lin, T.H, Lee, C.C.D, Wilson, I.A. | 登録日 | 2022-07-26 | 公開日 | 2022-11-23 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Rare, convergent antibodies targeting the stem helix broadly neutralize diverse betacoronaviruses. Cell Host Microbe, 31, 2023
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8DTR
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![BU of 8dtr by Molmil](/molmil-images/mine/8dtr) | Crystal structure of SARS-CoV-2 spike stem helix peptide in complex with neutralizing antibody COV30-14 | 分子名称: | COV30-14 heavy chain, COV30-14 light chain, Spike protein S2' stem helix peptide | 著者 | Lee, C.C.D, Lin, T.H, Wilson, I.A. | 登録日 | 2022-07-26 | 公開日 | 2022-11-23 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Rare, convergent antibodies targeting the stem helix broadly neutralize diverse betacoronaviruses. Cell Host Microbe, 31, 2023
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8DTT
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![BU of 8dtt by Molmil](/molmil-images/mine/8dtt) | Crystal structure of SARS-CoV-2 spike stem helix peptide in complex with neutralizing antibody COV93-03 | 分子名称: | COV93-03 heavy chain, COV93-03 light chain, Spike protein S2' stem helix peptide | 著者 | Lee, C.C.D, Lin, T.H, Wilson, I.A. | 登録日 | 2022-07-26 | 公開日 | 2022-11-23 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Rare, convergent antibodies targeting the stem helix broadly neutralize diverse betacoronaviruses. Cell Host Microbe, 31, 2023
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6C6N
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![BU of 6c6n by Molmil](/molmil-images/mine/6c6n) | |
6C6R
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![BU of 6c6r by Molmil](/molmil-images/mine/6c6r) | |
3CCN
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![BU of 3ccn by Molmil](/molmil-images/mine/3ccn) | X-ray structure of c-Met with triazolopyridazine inhibitor. | 分子名称: | 4-[(6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl]phenol, Hepatocyte growth factor receptor | 著者 | Abrecht, B.K, Harmange, J.-C, Bauer, D, Dussault, I, long, A, Bellon, S.F. | 登録日 | 2008-02-26 | 公開日 | 2008-04-29 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase. J.Med.Chem., 51, 2008
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3G42
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![BU of 3g42 by Molmil](/molmil-images/mine/3g42) | Crystal Structure of TACE with Tryptophan Sulfonamide Derivative Inhibitor | 分子名称: | ADAM 17, N-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}-5-methyl-D-tryptophan, ZINC ION | 著者 | Xu, W, Park, K, Gopalsamy, A, Aplasca, A, Zhang, Y.H, Levin, J.I. | 登録日 | 2009-02-03 | 公開日 | 2009-05-19 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Synthesis and activity of tryptophan sulfonamide derivatives as novel non-hydroxamate TNF-alpha converting enzyme (TACE) inhibitors. Bioorg.Med.Chem., 17, 2009
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3CD8
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![BU of 3cd8 by Molmil](/molmil-images/mine/3cd8) | X-ray Structure of c-Met with triazolopyridazine Inhibitor. | 分子名称: | 7-methoxy-4-[(6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline, Hepatocyte growth factor receptor | 著者 | Bellon, S.F, Albrecht, B.K, Harmange, J.-C, Bauer, D, Choquette, D, Dussault, I. | 登録日 | 2008-02-26 | 公開日 | 2008-04-29 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Discovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase. J.Med.Chem., 51, 2008
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5DWR
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![BU of 5dwr by Molmil](/molmil-images/mine/5dwr) | Identification of N-(4-((1R,3S,5S)-3-amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1,2 and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies | 分子名称: | N-{4-[(1R,3S,5S)-3-amino-5-methylcyclohexyl]pyridin-3-yl}-6-(2,6-difluorophenyl)-5-fluoropyridine-2-carboxamide, Serine/threonine-protein kinase pim-1 | 著者 | Bellamacina, C, Bussiere, D, Burger, M. | 登録日 | 2015-09-22 | 公開日 | 2015-11-11 | 最終更新日 | 2015-11-25 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Identification of N-(4-((1R,3S,5S)-3-Amino-5-methylcyclohexyl)pyridin-3-yl)-6-(2,6-difluorophenyl)-5-fluoropicolinamide (PIM447), a Potent and Selective Proviral Insertion Site of Moloney Murine Leukemia (PIM) 1, 2, and 3 Kinase Inhibitor in Clinical Trials for Hematological Malignancies. J.Med.Chem., 58, 2015
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1G69
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![BU of 1g69 by Molmil](/molmil-images/mine/1g69) | THIAMIN PHOSPHATE SYNTHASE | 分子名称: | 2-METHYL-5-METHYLENE-5H-PYRIMIDIN-4-YLIDENEAMINE, 4-METHYL-5-HYDROXYETHYLTHIAZOLE PHOSPHATE, MAGNESIUM ION, ... | 著者 | Peapus, D.H, Chiu, H.-J, Campobasso, N, Reddick, J.J, Begley, T.P, Ealick, S.E. | 登録日 | 2000-11-03 | 公開日 | 2001-09-26 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structural characterization of the enzyme-substrate, enzyme-intermediate, and enzyme-product complexes of thiamin phosphate synthase. Biochemistry, 40, 2001
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6JKM
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![BU of 6jkm by Molmil](/molmil-images/mine/6jkm) | Crystal structure of BubR1 kinase domain | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ... | 著者 | Lin, L, Ye, S, Huang, Y, Liu, X, Zhang, R, Yao, X. | 登録日 | 2019-03-01 | 公開日 | 2019-06-26 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules. Cell Res., 29, 2019
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8D1I
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![BU of 8d1i by Molmil](/molmil-images/mine/8d1i) | hBest1 1uM Ca2+ (Ca2+-bound) closed state | 分子名称: | 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, Bestrophin-1, CALCIUM ION | 著者 | Owji, A.P, Kittredge, A, Hendrickson, W.A, Tingting, Y. | 登録日 | 2022-05-27 | 公開日 | 2022-07-13 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (1.82 Å) | 主引用文献 | Structures and gating mechanisms of human bestrophin anion channels. Nat Commun, 13, 2022
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8D1G
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![BU of 8d1g by Molmil](/molmil-images/mine/8d1g) | hBest2 Ca2+-bound open state | 分子名称: | 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, Bestrophin-2, ... | 著者 | Owji, A.P, Kittredge, A, Hendrickson, W.A, Tingting, Y. | 登録日 | 2022-05-27 | 公開日 | 2022-07-13 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (2.07 Å) | 主引用文献 | Structures and gating mechanisms of human bestrophin anion channels. Nat Commun, 13, 2022
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8D1K
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![BU of 8d1k by Molmil](/molmil-images/mine/8d1k) | hBest1 Ca2+-bound partially open neck state | 分子名称: | 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, Bestrophin-1, CALCIUM ION | 著者 | Owji, A.P, Kittredge, A, Hendrickson, W.A, Tingting, Y. | 登録日 | 2022-05-27 | 公開日 | 2022-07-13 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (2.28 Å) | 主引用文献 | Structures and gating mechanisms of human bestrophin anion channels. Nat Commun, 13, 2022
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8D1O
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![BU of 8d1o by Molmil](/molmil-images/mine/8d1o) | hBest1_345 Ca2+-bound open state | 分子名称: | 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, Bestrophin-1, CALCIUM ION | 著者 | Owji, A.P, Kittredge, A, Hendrickson, W.A, Tingting, Y. | 登録日 | 2022-05-27 | 公開日 | 2022-07-13 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (2.44 Å) | 主引用文献 | Structures and gating mechanisms of human bestrophin anion channels. Nat Commun, 13, 2022
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8D1F
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![BU of 8d1f by Molmil](/molmil-images/mine/8d1f) | hBest2 5mM Ca2+ (Ca2+-bound) closed state | 分子名称: | 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, Bestrophin-2, ... | 著者 | Owji, A.P, Kittredge, A, Hendrickson, W.A, Tingting, Y. | 登録日 | 2022-05-27 | 公開日 | 2022-07-13 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (1.82 Å) | 主引用文献 | Structures and gating mechanisms of human bestrophin anion channels. Nat Commun, 13, 2022
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8D1N
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![BU of 8d1n by Molmil](/molmil-images/mine/8d1n) | bBest2_345 Ca2+-bound open state | 分子名称: | 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, Bestrophin, ... | 著者 | Owji, A.P, Kittredge, A, Hendrickson, W.A, Tingting, Y. | 登録日 | 2022-05-27 | 公開日 | 2022-07-13 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (1.93 Å) | 主引用文献 | Structures and gating mechanisms of human bestrophin anion channels. Nat Commun, 13, 2022
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8D1E
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![BU of 8d1e by Molmil](/molmil-images/mine/8d1e) | hBest2 1uM Ca2+ (Ca2+-bound) closed state | 分子名称: | 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, Bestrophin-2, ... | 著者 | Owji, A.P, Kittredge, A, Hendrickson, W.A, Tingting, Y. | 登録日 | 2022-05-27 | 公開日 | 2022-07-13 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (1.78 Å) | 主引用文献 | Structures and gating mechanisms of human bestrophin anion channels. Nat Commun, 13, 2022
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8D1L
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![BU of 8d1l by Molmil](/molmil-images/mine/8d1l) | hBest1 Ca2+-bound partially open aperture state | 分子名称: | 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, Bestrophin-1, CALCIUM ION, ... | 著者 | Owji, A.P, Kittredge, A, Hendrickson, W.A, Tingting, Y. | 登録日 | 2022-05-27 | 公開日 | 2022-07-13 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (2.12 Å) | 主引用文献 | Structures and gating mechanisms of human bestrophin anion channels. Nat Commun, 13, 2022
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8D1J
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![BU of 8d1j by Molmil](/molmil-images/mine/8d1j) | hBest1 5mM Ca2+ (Ca2+-bound) closed state | 分子名称: | 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, Bestrophin-1, CALCIUM ION | 著者 | Owji, A.P, Kittredge, A, Hendrickson, W.A, Tingting, Y. | 登録日 | 2022-05-27 | 公開日 | 2022-07-13 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (2.05 Å) | 主引用文献 | Structures and gating mechanisms of human bestrophin anion channels. Nat Commun, 13, 2022
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8D1M
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![BU of 8d1m by Molmil](/molmil-images/mine/8d1m) | |
8D1H
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![BU of 8d1h by Molmil](/molmil-images/mine/8d1h) | hBest2 Ca2+-unbound closed state | 分子名称: | 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, Bestrophin-2, ... | 著者 | Owji, A.P, Kittredge, A, Hendrickson, W.A, Tingting, Y. | 登録日 | 2022-05-27 | 公開日 | 2022-07-13 | 最終更新日 | 2024-02-14 | 実験手法 | ELECTRON MICROSCOPY (1.94 Å) | 主引用文献 | Structures and gating mechanisms of human bestrophin anion channels. Nat Commun, 13, 2022
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2E8T
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![BU of 2e8t by Molmil](/molmil-images/mine/2e8t) | S. cerevisiae geranylgeranyl pyrophosphate synthase in complex with magnesium, FsPP and IPP | 分子名称: | 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, Geranylgeranyl pyrophosphate synthetase, MAGNESIUM ION, ... | 著者 | Guo, R.T, Ko, T.P, Chen, C.K.-M, Jeng, W.Y, Chang, T.H, Liang, P.H, Oldfield, E, Wang, A.H.-J. | 登録日 | 2007-01-23 | 公開日 | 2007-06-12 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | 主引用文献 | Bisphosphonates target multiple sites in both cis- and trans-prenyltransferases Proc.Natl.Acad.Sci.Usa, 104, 2007
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6JKK
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![BU of 6jkk by Molmil](/molmil-images/mine/6jkk) | Crystal structure of BubR1 kinase domain | 分子名称: | DI(HYDROXYETHYL)ETHER, GLYCEROL, Mitotic checkpoint control protein kinase BUB1 | 著者 | Lin, L, Ye, S, Huang, Y, Liu, X, Zhang, R, Yao, X. | 登録日 | 2019-03-01 | 公開日 | 2019-06-26 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | BubR1 phosphorylates CENP-E as a switch enabling the transition from lateral association to end-on capture of spindle microtubules. Cell Res., 29, 2019
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