3CCN
X-ray structure of c-Met with triazolopyridazine inhibitor.
Summary for 3CCN
Entry DOI | 10.2210/pdb3ccn/pdb |
Related | 3CD8 |
Descriptor | Hepatocyte growth factor receptor, 4-[(6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl]phenol (3 entities in total) |
Functional Keywords | c-met kinase triazolopyridazine, atp-binding, glycoprotein, membrane, nucleotide-binding, phosphoprotein, proto-oncogene, receptor, transferase, transmembrane, tyrosine-protein kinase |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P08581 |
Total number of polymer chains | 1 |
Total formula weight | 35649.24 |
Authors | Abrecht, B.K.,Harmange, J.-C.,Bauer, D.,Dussault, I.,long, A.,Bellon, S.F. (deposition date: 2008-02-26, release date: 2008-04-29, Last modification date: 2023-08-30) |
Primary citation | Albrecht, B.K.,Harmange, J.C.,Bauer, D.,Berry, L.,Bode, C.,Boezio, A.A.,Chen, A.,Choquette, D.,Dussault, I.,Fridrich, C.,Hirai, S.,Hoffman, D.,Larrow, J.F.,Kaplan-Lefko, P.,Lin, J.,Lohman, J.,Long, A.M.,Moriguchi, J.,O'Connor, A.,Potashman, M.H.,Reese, M.,Rex, K.,Siegmund, A.,Shah, K.,Shimanovich, R.,Springer, S.K.,Teffera, Y.,Yang, Y.,Zhang, Y.,Bellon, S.F. Discovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase. J.Med.Chem., 51:2879-2882, 2008 Cited by PubMed: 18426196DOI: 10.1021/jm800043g PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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