3CCN
X-ray structure of c-Met with triazolopyridazine inhibitor.
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Hepatocyte growth factor receptor | polymer | 310 | 35346.9 | 1 | UniProt (P08581) Pfam (PF07714) In PDB | Homo sapiens (human) | HGF receptor, Scatter factor receptor, SF receptor, HGF/SF receptor, Met proto-oncogene tyrosine kinase, c-Met |
2 | A | 4-[(6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methyl]phenol | non-polymer | 302.3 | 1 | Chemie (LKG) | |||
3 | water | water | 18.0 | 177 | Chemie (HOH) |
Sequence modifications
A: 1048 - 1350 (UniProt: P08581)
PDB | External Database | Details |
---|---|---|
Met 1047 | - | initiating methionine |
Leu 1272 | Val 1272 | variant |
His 1351 | - | expression tag |
His 1352 | - | expression tag |
His 1353 | - | expression tag |
His 1354 | - | expression tag |
His 1355 | - | expression tag |
His 1356 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 35346.9 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 302.3 | |
All* | Total formula weight | 35649.2 |