8D1H

hBest2 Ca2+-unbound closed state

Summary for 8D1H

Entry DOI	10.2210/pdb8d1h/pdb
EMDB information	27127 27128 27129 27130 27131 27132 27133 27134 27135 27136 27137
Descriptor	Bestrophin-2, 1,2-DIMYRISTOYL-RAC-GLYCERO-3-PHOSPHOCHOLINE, 2-[2-[(1~{S},2~{S},4~{S},5'~{R},6~{R},7~{S},8~{R},9~{S},12~{S},13~{R},16~{S})-5',7,9,13-tetramethylspiro[5-oxapentacyclo[10.8.0.0^{2,9}.0^{4,8}.0^{13,18}]icos-18-ene-6,2'-oxane]-16-yl]oxyethyl]propane-1,3-diol, ... (5 entities in total)
Functional Keywords	ion channel, chloride channel, anion channel, pentamer, transport protein
Biological source	Homo sapiens (human)
Total number of polymer chains	5
Total formula weight	267110.69
Authors	Owji, A.P.,Kittredge, A.,Hendrickson, W.A.,Tingting, Y. (deposition date: 2022-05-27, release date: 2022-07-13, Last modification date: 2024-02-14)
Primary citation	Owji, A.P.,Wang, J.,Kittredge, A.,Clark, Z.,Zhang, Y.,Hendrickson, W.A.,Yang, T. Structures and gating mechanisms of human bestrophin anion channels. Nat Commun, 13:3836-3836, 2022 Cited by PubMed: 35789156 DOI: 10.1038/s41467-022-31437-7 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (1.94 Å)

Structure validation