3CD8

X-ray Structure of c-Met with triazolopyridazine Inhibitor.

Summary for 3CD8

• Entry DOI: 10.2210/pdb3cd8/pdb
• Related: 3CCN
• Descriptor: Hepatocyte growth factor receptor, 7-methoxy-4-[(6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline (3 entities in total)
• Functional Keywords: c-met, kinase, triazolopyridazine, atp-binding, glycoprotein, membrane, nucleotide-binding, phosphoprotein, proto-oncogene, receptor, transferase, transmembrane, tyrosine-protein kinase
• Biological source: Homo sapiens (human)
• Cellular location: Membrane; Single-pass type I membrane protein: P08581
• Total number of polymer chains: 1
• Total formula weight: 35730.31

Authors

Bellon, S.F.,Albrecht, B.K.,Harmange, J.-C.,Bauer, D.,Choquette, D.,Dussault, I. (deposition date: 2008-02-26, release date: 2008-04-29, Last modification date: 2023-08-30)

• Primary citation: Albrecht, B.K.,Harmange, J.C.,Bauer, D.,Berry, L.,Bode, C.,Boezio, A.A.,Chen, A.,Choquette, D.,Dussault, I.,Fridrich, C.,Hirai, S.,Hoffman, D.,Larrow, J.F.,Kaplan-Lefko, P.,Lin, J.,Lohman, J.,Long, A.M.,Moriguchi, J.,O'Connor, A.,Potashman, M.H.,Reese, M.,Rex, K.,Siegmund, A.,Shah, K.,Shimanovich, R.,Springer, S.K.,Teffera, Y.,Yang, Y.,Zhang, Y.,Bellon, S.F.; Discovery and Optimization of Triazolopyridazines as Potent and Selective Inhibitors of the c-Met Kinase.; J.Med.Chem., 51:2879-2882, 2008; PubMed: 18426196; DOI: 10.1021/jm800043g

Experimental method

X-RAY DIFFRACTION (2 Å)