3CD8

X-ray Structure of c-Met with triazolopyridazine Inhibitor.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Hepatocyte growth factor receptor	polymer	310	35346.9	1	UniProt (P08581) Pfam (PF07714) In PDB	Homo sapiens (human)	HGF receptor, Scatter factor receptor, SF receptor, HGF/SF receptor, Met proto-oncogene tyrosine kinase, c-Met
2	A	7-methoxy-4-[(6-phenyl[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy]quinoline	non-polymer		383.4	1	Chemie (L5G)
3		water	water		18.0	140	Chemie (HOH)

Sequence modifications

A: 1048 - 1350 (UniProt: P08581)

PDB	External Database	Details
Met 1047	-	initiating methionine
Leu 1272	Val 1272	variant
His 1351	-	expression tag
His 1352	-	expression tag
His 1353	-	expression tag
His 1354	-	expression tag
His 1355	-	expression tag
His 1356	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	35346.9
Non-Polymers*	Number of molecules	1
	Total formula weight	383.4
All*	Total formula weight	35730.3

*Water molecules are not included.