5YD0
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4I51
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![BU of 4i51 by Molmil](/molmil-images/mine/4i51) | Methyltransferase domain of HUMAN EUCHROMATIC HISTONE METHYLTRANSFERASE 1, mutant Y1211A | 分子名称: | GLYCEROL, H3K9 NE-ALLYL PEPTIDE, Histone-lysine N-methyltransferase EHMT1, ... | 著者 | Dong, A, Zeng, H, Walker, J.R, Islam, K, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Lou, M, Min, J, Wu, H, Structural Genomics Consortium (SGC) | 登録日 | 2012-11-28 | 公開日 | 2012-12-19 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Defining efficient enzyme-cofactor pairs for bioorthogonal profiling of protein methylation. Proc.Natl.Acad.Sci.USA, 110, 2013
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1FOC
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![BU of 1foc by Molmil](/molmil-images/mine/1foc) | Cytochrome C557: improperly folded thermus thermophilus C552 | 分子名称: | CYTOCHROME RC557, HEME C | 著者 | McRee, D.E, Williams, P.A, Fee, J.A, Bren, K.L. | 登録日 | 2000-08-27 | 公開日 | 2000-11-08 | 最終更新日 | 2021-03-03 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Recombinant cytochrome rC557 obtained from Escherichia coli cells expressing a truncated Thermus thermophilus cycA gene. Heme inversion in an improperly matured protein J.Biol.Chem., 276, 2001
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4MQ2
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![BU of 4mq2 by Molmil](/molmil-images/mine/4mq2) | The crystal structure of DYRK1a with a bound pyrido[2,3-d]pyrimidine inhibitor | 分子名称: | Dual specificity tyrosine-phosphorylation-regulated kinase 1A, PENTAETHYLENE GLYCOL, SULFATE ION, ... | 著者 | Lukacs, C.M, Janson, C.A, Garvie, C, Liang, L. | 登録日 | 2013-09-15 | 公開日 | 2013-12-11 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Pyrido[2,3-d]pyrimidines: Discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
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7VUE
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![BU of 7vue by Molmil](/molmil-images/mine/7vue) | Structural insight of the molecular mechanism of cilofexor bound to FXR | 分子名称: | 2-[3-[4-[[3-[2,6-bis(chloranyl)phenyl]-5-cyclopropyl-1,2-oxazol-4-yl]methoxy]-2-chloranyl-phenyl]-3-oxidanyl-azetidin-1-yl]pyridine-4-carboxylic acid, Bile acid receptor, Peptide from Nuclear receptor coactivator 2 | 著者 | Jiang, L, Chen, Y.C. | 登録日 | 2021-11-02 | 公開日 | 2022-03-16 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.601 Å) | 主引用文献 | Structural insight into the molecular mechanism of cilofexor binding to the farnesoid X receptor. Biochem.Biophys.Res.Commun., 595, 2022
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4RJ3
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![BU of 4rj3 by Molmil](/molmil-images/mine/4rj3) | CDK2 with EGFR inhibitor compound 8 | 分子名称: | 1-cyclopentyl-N-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-1H-pyrrolo[3,2-c]pyridin-6-amine, ACETATE ION, Cyclin-dependent kinase 2 | 著者 | Eigenbrot, C, Yin, J. | 登録日 | 2014-10-08 | 公開日 | 2014-11-26 | 最終更新日 | 2015-01-14 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation. J.Med.Chem., 57, 2014
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4RJ6
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![BU of 4rj6 by Molmil](/molmil-images/mine/4rj6) | EGFR kinase (T790M/L858R) with inhibitor compound 4 | 分子名称: | Epidermal growth factor receptor, N-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-2-(1H-pyrazol-4-yl)-3H-imidazo[4,5-c]pyridin-6-amine, SULFATE ION | 著者 | Eigenbrot, C, Yu, C. | 登録日 | 2014-10-08 | 公開日 | 2014-11-26 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation. J.Med.Chem., 57, 2014
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4RJ4
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![BU of 4rj4 by Molmil](/molmil-images/mine/4rj4) | EGFR kinase (T790M/L858R) with inhibitor compound 6 | 分子名称: | Epidermal growth factor receptor, N-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-1-(propan-2-yl)-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine | 著者 | Eigenbrot, C, Yu, C. | 登録日 | 2014-10-08 | 公開日 | 2014-11-26 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.78 Å) | 主引用文献 | Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation. J.Med.Chem., 57, 2014
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4RJ5
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![BU of 4rj5 by Molmil](/molmil-images/mine/4rj5) | EGFR kinase (T790M/L858R) with inhibitor compound 5 | 分子名称: | Epidermal growth factor receptor, N-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-2-(1H-pyrazol-4-yl)-1H-pyrrolo[3,2-c]pyridin-6-amine | 著者 | Eigenbrot, C, Yu, C. | 登録日 | 2014-10-08 | 公開日 | 2014-11-26 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation. J.Med.Chem., 57, 2014
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4RJ8
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![BU of 4rj8 by Molmil](/molmil-images/mine/4rj8) | EGFR kinase (T790M/L858R) with inhibitor compound 8 | 分子名称: | 1-cyclopentyl-N-[2-(4-methoxypiperidin-1-yl)pyrimidin-4-yl]-1H-pyrrolo[3,2-c]pyridin-6-amine, Epidermal growth factor receptor, SULFATE ION | 著者 | Eigenbrot, C, Yu, C. | 登録日 | 2014-10-08 | 公開日 | 2014-11-26 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation. J.Med.Chem., 57, 2014
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4RJ7
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![BU of 4rj7 by Molmil](/molmil-images/mine/4rj7) | EGFR kinase (T790M/L858R) with inhibitor compound 1 | 分子名称: | 2,6-dichloro-N-{2-[(2-{[(2S)-1-hydroxypropan-2-yl]amino}-6-methylpyrimidin-4-yl)amino]pyridin-4-yl}benzamide, Epidermal growth factor receptor, SULFATE ION | 著者 | Eigenbrot, C, Yu, C. | 登録日 | 2014-10-08 | 公開日 | 2014-11-26 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Discovery of Selective and Noncovalent Diaminopyrimidine-Based Inhibitors of Epidermal Growth Factor Receptor Containing the T790M Resistance Mutation. J.Med.Chem., 57, 2014
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4IXP
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7EPX
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![BU of 7epx by Molmil](/molmil-images/mine/7epx) | S protein of SARS-CoV-2 in complex with GW01 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ... | 著者 | Shen, Y.P, Zhang, Y.Y, Yan, R.H, Li, Y.N, Zhou, Q. | 登録日 | 2021-04-28 | 公開日 | 2022-05-18 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Novel sarbecovirus bispecific neutralizing antibodies with exceptional breadth and potency against currently circulating SARS-CoV-2 variants and sarbecoviruses. Cell Discov, 8, 2022
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4E0H
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![BU of 4e0h by Molmil](/molmil-images/mine/4e0h) | Crystal structure of FAD binding domain of Erv1 from Saccharomyces cerevisiae | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Mitochondrial FAD-linked sulfhydryl oxidase ERV1 | 著者 | Guo, P.C, Ma, J.D, Jiang, Y.L, Wang, S.J, Hu, T.T, Chen, Y.X, Zhou, C.Z. | 登録日 | 2012-03-04 | 公開日 | 2012-08-29 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of yeast sulfhydryl oxidase erv1 reveals electron transfer of the disulfide relay system in the mitochondrial intermembrane space J.Biol.Chem., 287, 2012
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4E0I
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![BU of 4e0i by Molmil](/molmil-images/mine/4e0i) | Crystal structure of the C30S/C133S mutant of Erv1 from Saccharomyces cerevisiae | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Mitochondrial FAD-linked sulfhydryl oxidase ERV1 | 著者 | Guo, P.C, Ma, J.D, Jiang, Y.L, Wang, S.J, Hu, T.T, Chen, Y.X, Zhou, C.Z. | 登録日 | 2012-03-04 | 公開日 | 2012-08-29 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structure of yeast sulfhydryl oxidase erv1 reveals electron transfer of the disulfide relay system in the mitochondrial intermembrane space J.Biol.Chem., 287, 2012
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7FJ1
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![BU of 7fj1 by Molmil](/molmil-images/mine/7fj1) | Cryo-EM structure of pseudorabies virus C-capsid | 分子名称: | Capsid vertex component 1, DNA packaging tegument protein UL25, Major capsid protein, ... | 著者 | Zheng, Q, Li, S, Zha, Z, Sun, H. | 登録日 | 2021-08-02 | 公開日 | 2022-06-22 | 実験手法 | ELECTRON MICROSCOPY (4.43 Å) | 主引用文献 | Structures of pseudorabies virus capsids. Nat Commun, 13, 2022
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7FJ3
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![BU of 7fj3 by Molmil](/molmil-images/mine/7fj3) | Cryo-EM structure of PRV A-capid | 分子名称: | Major capsid protein, Small capsomere-interacting protein, Triplex capsid protein 1, ... | 著者 | Zheng, Q, Li, S, Zha, Z, Sun, H. | 登録日 | 2021-08-02 | 公開日 | 2022-06-22 | 実験手法 | ELECTRON MICROSCOPY (4.53 Å) | 主引用文献 | Structures of pseudorabies virus capsids. Nat Commun, 13, 2022
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7FAH
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![BU of 7fah by Molmil](/molmil-images/mine/7fah) | Immune complex of head region of CA09 HA and neutralizing antibody 12H5 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... | 著者 | Li, T.T, Xue, W.H, Gu, Y, Li, S.W. | 登録日 | 2021-07-06 | 公開日 | 2022-07-06 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.151 Å) | 主引用文献 | Identification of a cross-neutralizing antibody that targets the receptor binding site of H1N1 and H5N1 influenza viruses. Nat Commun, 13, 2022
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4JO1
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7X4X
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![BU of 7x4x by Molmil](/molmil-images/mine/7x4x) | BTB domain of KEAP1 in complex with MEF | 分子名称: | 4-ethoxy-4-oxobutanoic acid, Kelch-like ECH-associated protein 1 | 著者 | Qu, L.Z. | 登録日 | 2022-03-03 | 公開日 | 2023-03-08 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.96 Å) | 主引用文献 | Characterization of the modification of Kelch-like ECH-associated protein 1 by different fumarates. Biochem.Biophys.Res.Commun., 605, 2022
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7X4W
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7XJR
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![BU of 7xjr by Molmil](/molmil-images/mine/7xjr) | MLXase AlXyn26A | 分子名称: | AlXyn26A | 著者 | Zhang, Y.Z, Chen, X.L, Zhao, F, Yu, C.M. | 登録日 | 2022-04-18 | 公開日 | 2023-04-26 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | A novel class of xylanases specifically degrade marine red algal beta 1,3/1,4-mixed-linkage xylan. J.Biol.Chem., 299, 2023
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4MQ1
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![BU of 4mq1 by Molmil](/molmil-images/mine/4mq1) | The crystal structure of DYRK1a with a bound pyrido[2,3-d]pyrimidine inhibitor | 分子名称: | Dual specificity tyrosine-phosphorylation-regulated kinase 1A, N-(5-{[(1R)-3-amino-1-(3-chlorophenyl)propyl]carbamoyl}-2-chlorophenyl)-2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide, PENTAETHYLENE GLYCOL, ... | 著者 | Lukacs, C.M, Janson, C.A, Garvie, C, Liang, L. | 登録日 | 2013-09-15 | 公開日 | 2013-12-11 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Pyrido[2,3-d]pyrimidines: Discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
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4JO2
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7EQ2
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![BU of 7eq2 by Molmil](/molmil-images/mine/7eq2) | Crystal structure of GDP-bound Rab1a-T75D | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, COBALT HEXAMMINE(III), ... | 著者 | Cao, Y.L, Gu, D.D, Gao, S. | 登録日 | 2021-04-28 | 公開日 | 2022-11-02 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.55090284 Å) | 主引用文献 | Aurora kinase A-mediated phosphorylation triggers structural alteration of Rab1A to enhance ER complexity during mitosis Nat.Struct.Mol.Biol., 2024
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