4MQ2
The crystal structure of DYRK1a with a bound pyrido[2,3-d]pyrimidine inhibitor
Summary for 4MQ2
Entry DOI | 10.2210/pdb4mq2/pdb |
Related | 2vx3 4MQ1 |
Descriptor | Dual specificity tyrosine-phosphorylation-regulated kinase 1A, methyl 4-chloro-3-{[(2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-6-yl)carbonyl]amino}benzoate, PENTAETHYLENE GLYCOL, ... (5 entities in total) |
Functional Keywords | dyrk1a, dyrk1b, kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus speckle: Q13627 |
Total number of polymer chains | 4 |
Total formula weight | 171791.17 |
Authors | Lukacs, C.M.,Janson, C.A.,Garvie, C.,Liang, L. (deposition date: 2013-09-15, release date: 2013-12-11, Last modification date: 2023-12-06) |
Primary citation | Anderson, K.,Chen, Y.,Chen, Z.,Dominique, R.,Glenn, K.,He, Y.,Janson, C.,Luk, K.C.,Lukacs, C.,Polonskaia, A.,Qiao, Q.,Railkar, A.,Rossman, P.,Sun, H.,Xiang, Q.,Vilenchik, M.,Wovkulich, P.,Zhang, X. Pyrido[2,3-d]pyrimidines: Discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors. Bioorg.Med.Chem.Lett., 23:6610-6615, 2013 Cited by PubMed: 24239188DOI: 10.1016/j.bmcl.2013.10.055 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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