4MQ2

The crystal structure of DYRK1a with a bound pyrido[2,3-d]pyrimidine inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
A	0046777	biological_process	protein autophosphorylation
B	0004672	molecular_function	protein kinase activity
B	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
B	0046777	biological_process	protein autophosphorylation
C	0004672	molecular_function	protein kinase activity
C	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation
C	0046777	biological_process	protein autophosphorylation
D	0004672	molecular_function	protein kinase activity
D	0004712	molecular_function	protein serine/threonine/tyrosine kinase activity
D	0005524	molecular_function	ATP binding
D	0006468	biological_process	protein phosphorylation
D	0046777	biological_process	protein autophosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 2C4 A 501

Chain	Residue
A	PHE170
A	ASP307
A	1PE502
A	VAL173
A	LYS188
A	PHE238
A	GLU239
A	MET240
A	LEU241
A	SER242
A	TYR243

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 1PE A 502

Chain	Residue
A	ASP162
A	LYS175
A	TRP184
A	MET240
A	2C4501

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE 1PE A 503

Chain	Residue
A	GLN201
A	HIS227
C	GLN201

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 504

Chain	Residue
A	ARG467
A	ILE468
A	GLN469
A	TYR472

---

site_id	AC5
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 A 505

Chain	Residue
A	PRO279
A	SER282
A	GLN313

---

site_id	AC6
Number of Residues	11
Details	BINDING SITE FOR RESIDUE 2C4 B 501

Chain	Residue
B	LYS188
B	PHE238
B	GLU239
B	MET240
B	LEU241
B	SER242
B	TYR243
B	LEU294
B	VAL306
B	ASP307
B	1PE502

---

site_id	AC7
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 1PE B 502

Chain	Residue
B	ASP162
B	SER163
B	LYS175
B	TRP184
B	2C4501

---

site_id	AC8
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 1PE B 503

Chain	Residue
B	GLN201
B	HIS227
B	MET229
D	GLN201
D	HIS227

---

site_id	AC9
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 B 504

Chain	Residue
B	THR466
B	ARG467
B	ILE468
B	GLN469
B	TYR472

---

site_id	BC1
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 505

Chain	Residue
B	PTR321
B	ARG325
B	ARG328

---

site_id	BC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 B 506

Chain	Residue
B	LYS264
B	ARG300
B	SER301

---

site_id	BC3
Number of Residues	13
Details	BINDING SITE FOR RESIDUE 2C4 C 501

Chain	Residue
C	ILE165
C	PHE170
C	VAL173
C	ALA186
C	LYS188
C	PHE238
C	GLU239
C	MET240
C	LEU241
C	SER242
C	LEU294
C	ASP307
C	1PE502

---

site_id	BC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE 1PE C 502

Chain	Residue
C	ASP162
C	LYS175
C	TRP184
C	2C4501

---

site_id	BC5
Number of Residues	12
Details	BINDING SITE FOR RESIDUE 2C4 D 501

Chain	Residue
D	ILE165
D	PHE170
D	LYS188
D	PHE238
D	GLU239
D	LEU241
D	SER242
D	TYR243
D	LEU294
D	VAL306
D	ASP307
D	1PE502

---

site_id	BC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE 1PE D 502

Chain	Residue
B	TYR246
D	ASP162
D	LYS175
D	TRP184
D	2C4501

---

Functional Information from PROSITE/UniProt

site_id	PS00107
Number of Residues	24
Details	PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. IGKGSFGQVVkAydrveqew..........VAIK

Chain	Residue	Details
A	ILE165-LYS188

---

site_id	PS00108
Number of Residues	13
Details	PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiHcDLKpeNILL

Chain	Residue	Details
A	ILE283-LEU295

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	34
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	Active site: {"description":"Proton acceptor","evidences":[{"source":"PubMed","id":"23665168","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	48
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	24
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"PubMed","id":"23665168","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine; by autocatalysis","evidences":[{"source":"UniProtKB","id":"Q63470","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine; by autocatalysis","evidences":[{"source":"PubMed","id":"23665168","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"Phosphothreonine; by autocatalysis","evidences":[{"source":"PubMed","id":"23665168","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---