7D3E
 
 | |
7DXD
 | |
7D3F
 | |
7DXF
 | |
7DXC
 | | Structure of TRPC3 at 3.06 angstrom in low calcium state | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CHOLESTEROL HEMISUCCINATE, Short transient receptor potential channel 3, ... | | 著者 | Chen, L, Guo, W. | | 登録日 | 2021-01-18 | | 公開日 | 2022-02-02 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | | 主引用文献 | Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites.
Neuron, 110, 2022
|
|
7DXG
 | | Structure of SAR7334-bound TRPC6 at 2.9 angstrom | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 4-[[(1R,2R)-2-[(3R)-3-azanylpiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloranyl-benzenecarbonitrile, CALCIUM ION, ... | | 著者 | Chen, L, Guo, W. | | 登録日 | 2021-01-18 | | 公開日 | 2022-02-02 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites.
Neuron, 110, 2022
|
|
7DXE
 | |
7DXB
 | | Structure of TRPC3 at 2.7 angstrom in high calcium state | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... | | 著者 | Chen, L, Guo, W. | | 登録日 | 2021-01-18 | | 公開日 | 2022-02-02 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites.
Neuron, 110, 2022
|
|
7CU3
 | |
3RJ2
 | |
3RPT
 | |
7BR3
 | | Crystal structure of the protein 1 | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2R)-2,3-dihydroxypropyl dodecanoate, 4-[[(1R)-2-[5-(2-fluoranyl-3-methoxy-phenyl)-3-[[2-fluoranyl-6-(trifluoromethyl)phenyl]methyl]-4-methyl-2,6-bis(oxidanylidene)pyrimidin-1-yl]-1-phenyl-ethyl]amino]butanoic acid, ... | | 著者 | Cheng, L, Shao, Z. | | 登録日 | 2020-03-26 | | 公開日 | 2020-10-07 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.79 Å) | | 主引用文献 | Structure of the human gonadotropin-releasing hormone receptor GnRH1R reveals an unusual ligand binding mode.
Nat Commun, 11, 2020
|
|
8JZ7
 | | Cryo-EM structure of MK-6892-bound HCAR2 in complex with Gi protein | | 分子名称: | 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Zhao, C, Tian, X.W, Liu, Y, Cheng, L, Yan, W, Shao, Z.H. | | 登録日 | 2023-07-04 | | 公開日 | 2023-10-04 | | 最終更新日 | 2024-11-06 | | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | | 主引用文献 | Orthosteric ligand selectivity and allosteric probe dependence at Hydroxycarboxylic acid receptor HCAR2.
Signal Transduct Target Ther, 8, 2023
|
|
4U5J
 | | C-Src in complex with Ruxolitinib | | 分子名称: | (3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile, Proto-oncogene tyrosine-protein kinase Src | | 著者 | Chen, Y, Duan, Y, Chen, L. | | 登録日 | 2014-07-25 | | 公開日 | 2014-09-17 | | 最終更新日 | 2024-06-26 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | c-Src Binds to the Cancer Drug Ruxolitinib with an Active Conformation
Plos One, 9, 2014
|
|
3DFV
 | | Adjacent GATA DNA binding | | 分子名称: | DNA (5'-D(*DAP*DAP*DGP*DCP*DAP*DGP*DAP*DTP*DAP*DAP*DGP*DTP*DCP*DTP*DTP*DAP*DTP*DCP*DAP*DG)-3'), DNA (5'-D(*DTP*DTP*DCP*DTP*DGP*DAP*DTP*DAP*DAP*DGP*DAP*DCP*DTP*DTP*DAP*DTP*DCP*DTP*DGP*DC)-3'), Trans-acting T-cell-specific transcription factor GATA-3, ... | | 著者 | Bates, D.L, Kim, G.K, Guo, L, Chen, L. | | 登録日 | 2008-06-12 | | 公開日 | 2008-07-29 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Crystal structures of multiple GATA zinc fingers bound to DNA reveal new insights into DNA recognition and self-association by GATA.
J.Mol.Biol., 381, 2008
|
|
4DGP
 | | The wild-type Src homology 2 (SH2)-domain containing protein tyrosine phosphatase-2 (SHP2) | | 分子名称: | Tyrosine-protein phosphatase non-receptor type 11 | | 著者 | Yu, Z.H, Xu, J, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L.N, Liu, S.J, Zhang, Z.Y. | | 登録日 | 2012-01-26 | | 公開日 | 2013-03-06 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations.
J.Biol.Chem., 288, 2013
|
|
3JWD
 | | Structure of HIV-1 gp120 with gp41-Interactive Region: Layered Architecture and Basis of Conformational Mobility | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, FAB 48D HEAVY CHAIN, FAB 48D LIGHT CHAIN, ... | | 著者 | Pancera, M, Majeed, S, Ban, Y.A, Chen, L, Huang, C.C, Kong, L, Kwon, Y.D, Stuckey, J, Zhou, T, Robinson, J.E, Schief, W.R, Sodroski, J, Wyatt, R, Kwong, P.D. | | 登録日 | 2009-09-18 | | 公開日 | 2009-12-29 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | | 主引用文献 | Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility.
Proc.Natl.Acad.Sci.USA, 107, 2010
|
|
4WBX
 | | Conserved hypothetical protein PF1771 from Pyrococcus furiosus solved by sulfur SAD using Swiss Light Source data | | 分子名称: | 2-keto acid:ferredoxin oxidoreductase subunit alpha | | 著者 | Weinert, T, Waltersperger, S, Olieric, V, Panepucci, E, Chen, L, Rose, J.P, Wang, M, Wang, B.C, Southeast Collaboratory for Structural Genomics (SECSG) | | 登録日 | 2014-09-04 | | 公開日 | 2014-12-10 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.301 Å) | | 主引用文献 | Fast native-SAD phasing for routine macromolecular structure determination.
Nat.Methods, 12, 2015
|
|
4U2R
 | | Crystal structure of the GLUR2 ligand binding core (S1S2J, flip variant) in the apo state | | 分子名称: | Glutamate receptor 2, SULFATE ION | | 著者 | Duerr, K.L, Chen, L, Gouaux, E. | | 登録日 | 2014-07-17 | | 公開日 | 2014-08-20 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (1.4114 Å) | | 主引用文献 | Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States.
Cell, 158, 2014
|
|
4U2Q
 | | Full-length AMPA subtype ionotropic glutamate receptor GluA2 in complex with partial agonist kainate | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, Glutamate receptor 2 | | 著者 | Duerr, K.L, Chen, L, Gouaux, E. | | 登録日 | 2014-07-17 | | 公開日 | 2014-08-20 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (3.5247 Å) | | 主引用文献 | Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States.
Cell, 158, 2014
|
|
9BEL
 | | Tungstate binding protein (Tungbindin) from Eubacterium limosum with five Tungstates bound | | 分子名称: | Molybdenum-pterin binding domain-containing protein, SULFATE ION, TUNGSTATE(VI)ION | | 著者 | Zhou, D, Rose, J.P, Chen, L, Wang, B.C. | | 登録日 | 2024-04-15 | | 公開日 | 2024-09-04 | | 最終更新日 | 2025-04-23 | | 実験手法 | X-RAY DIFFRACTION (2.68 Å) | | 主引用文献 | Storage of the vital metal tungsten in a dominant SCFA-producing human gut microbe Eubacterium limosum and implications for other gut microbes.
Mbio, 16, 2025
|
|
2IEL
 | | CRYSTAL STRUCTURE OF TT0030 from Thermus Thermophilus | | 分子名称: | Hypothetical Protein TT0030 | | 著者 | Zhu, J, Huang, J, Stepanyuk, G, Chen, L, Chang, J, Zhao, M, Xu, H, Liu, Z.J, Rose, J.P, Wang, B.C, Southeast Collaboratory for Structural Genomics (SECSG) | | 登録日 | 2006-09-19 | | 公開日 | 2006-11-14 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | CRYSTAL STRUCTURE OF TT0030 from Thermus Thermophilus AT 1.6 ANGSTROMS RESOLUTION
To be Published
|
|
2IIH
 | | Crystal structure of the molybdenum cofactor biosynthesis protein C (TTHA1789) from thermus theromophilus HB8 (H32 form) | | 分子名称: | Molybdenum cofactor biosynthesis protein C, PHOSPHATE ION | | 著者 | Jeyakanthan, J, Kanaujia, S.P, Vasuki Ranjani, C, Sekar, K, Baba, S, Chen, L, Liu, Z.-J, Wang, B.-C, Ebihara, A, Kuramitsu, S, Shinkai, A, Shiro, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2006-09-28 | | 公開日 | 2007-10-09 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Crystal structure of the molybdenum cofactor biosynthesis protein C (TTHA1789) from thermus theromophilus HB8 (H32 form)
To be Published
|
|
9M5V
 | | Structure of human TRPC5 bound with (-)-englerin A,class1 | | 分子名称: | (-)-englerin A, CALCIUM ION, CHOLESTEROL HEMISUCCINATE, ... | | 著者 | Chen, Y.K, Wei, M, Chen, L, Guo, W.J. | | 登録日 | 2025-03-06 | | 公開日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (2.53 Å) | | 主引用文献 | Class1 structure of human TRPC5 bound with (-)-englerin A
To Be Published
|
|
9M4W
 | | Structure of human TRPC5 bound with (-)-englerin A, class 2. | | 分子名称: | (-)-englerin A, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CHOLESTEROL HEMISUCCINATE, ... | | 著者 | Chen, Y.K, Wei, M, Chen, L. | | 登録日 | 2025-03-05 | | 公開日 | 2025-07-02 | | 実験手法 | ELECTRON MICROSCOPY (2.62 Å) | | 主引用文献 | Structure of human TRPC5 bound with (-)-englerin A, class 2.
To Be Published
|
|
