7R5G
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7RCU
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![BU of 7rcu by Molmil](/molmil-images/mine/7rcu) | Synthetic Max homodimer mimic in complex with DNA | 分子名称: | 2'-DEOXYADENOSINE-5'-MONOPHOSPHATE, 2-(2,5-dioxopyrrolidin-1-yl)acetamide, ACETAMIDE, ... | 著者 | Speltz, T, Qiao, Z, Shangguan, S, Fanning, S, Greene, J, Moellering, R. | 登録日 | 2021-07-08 | 公開日 | 2022-09-14 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | 主引用文献 | Targeting MYC with modular synthetic transcriptional repressors derived from bHLH DNA-binding domains. Nat.Biotechnol., 41, 2023
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7S8O
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![BU of 7s8o by Molmil](/molmil-images/mine/7s8o) | CryoEM structure of Gi-coupled MRGPRX2 with small molecule agonist (R)-Zinc-3573 | 分子名称: | (3R)-N,N-dimethyl-1-[(8S)-5-phenylpyrazolo[1,5-a]pyrimidin-7-yl]pyrrolidin-3-amine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Cao, C, Fay, J.F, Gumpper, R.H, Roth, B.L. | 登録日 | 2021-09-18 | 公開日 | 2021-11-17 | 最終更新日 | 2021-12-15 | 実験手法 | ELECTRON MICROSCOPY (2.58 Å) | 主引用文献 | Structure, function and pharmacology of human itch GPCRs. Nature, 600, 2021
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7S8L
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![BU of 7s8l by Molmil](/molmil-images/mine/7s8l) | CryoEM structure of Gq-coupled MRGPRX2 with peptide agonist Cortistatin-14 | 分子名称: | Cortistatin 14, Gs-mini-Gq chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Cao, C, Fay, J.F, Gumpper, R.H, Roth, B.L. | 登録日 | 2021-09-18 | 公開日 | 2021-11-17 | 最終更新日 | 2021-12-15 | 実験手法 | ELECTRON MICROSCOPY (2.45 Å) | 主引用文献 | Structure, function and pharmacology of human itch GPCRs. Nature, 600, 2021
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7S8P
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![BU of 7s8p by Molmil](/molmil-images/mine/7s8p) | CryoEM structure of Gq-coupled MRGPRX4 with small molecule agonist MS47134 | 分子名称: | Gs-mini-Gq chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Cao, C, Fay, J.F, Gumpper, R.H, Roth, B.L. | 登録日 | 2021-09-18 | 公開日 | 2021-11-17 | 最終更新日 | 2021-12-15 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Structure, function and pharmacology of human itch GPCRs. Nature, 600, 2021
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7S8M
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![BU of 7s8m by Molmil](/molmil-images/mine/7s8m) | CryoEM structure of Gi-coupled MRGPRX2 with peptide agonist Cortistatin-14 | 分子名称: | Cortistatin 14, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Cao, C, Fay, J.F, Gumpper, R.H, Roth, B.L. | 登録日 | 2021-09-18 | 公開日 | 2021-11-17 | 最終更新日 | 2021-12-15 | 実験手法 | ELECTRON MICROSCOPY (2.54 Å) | 主引用文献 | Structure, function and pharmacology of human itch GPCRs. Nature, 600, 2021
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7S8N
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![BU of 7s8n by Molmil](/molmil-images/mine/7s8n) | CryoEM structure of Gq-coupled MRGPRX2 with small molecule agonist (R)-Zinc-3573 | 分子名称: | (3R)-N,N-dimethyl-1-[(8S)-5-phenylpyrazolo[1,5-a]pyrimidin-7-yl]pyrrolidin-3-amine, Gs-mini-Gq chimera, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Cao, C, Fay, J.F, Gumpper, R.H, Roth, B.L. | 登録日 | 2021-09-18 | 公開日 | 2021-11-17 | 最終更新日 | 2021-12-15 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structure, function and pharmacology of human itch GPCRs. Nature, 600, 2021
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6ZDW
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3RIG
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1AH7
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![BU of 1ah7 by Molmil](/molmil-images/mine/1ah7) | PHOSPHOLIPASE C FROM BACILLUS CEREUS | 分子名称: | PHOSPHOLIPASE C, ZINC ION | 著者 | Greaves, R. | 登録日 | 1997-04-14 | 公開日 | 1997-12-10 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.501 Å) | 主引用文献 | High-resolution (1.5 A) crystal structure of phospholipase C from Bacillus cereus. Nature, 338, 1989
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3RIY
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3E8C
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![BU of 3e8c by Molmil](/molmil-images/mine/3e8c) | Crystal structures of the kinase domain of PKA in complex with ATP-competitive inhibitors | 分子名称: | 4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-6-{[(2R)-2-amino-3-phenylpropyl]oxy}-1-ethyl-1H-imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor peptide | 著者 | Concha, N.O, Elkins, P.A, Smallwood, A, Ward, P. | 登録日 | 2008-08-19 | 公開日 | 2008-11-18 | 最終更新日 | 2017-10-25 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Aminofurazans as potent inhibitors of AKT kinase Bioorg.Med.Chem.Lett., 19, 2009
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5BK8
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![BU of 5bk8 by Molmil](/molmil-images/mine/5bk8) | Cancer-associated SHP2/T507K mutant | 分子名称: | Tyrosine-protein phosphatase non-receptor type 11 | 著者 | Yu, Z.H, Zhang, R.Y, Zhang, Z.Y. | 登録日 | 2019-06-01 | 公開日 | 2020-04-08 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Mechanistic insights explain the transforming potential of the T507K substitution in the protein-tyrosine phosphatase SHP2. J.Biol.Chem., 295, 2020
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3E8D
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![BU of 3e8d by Molmil](/molmil-images/mine/3e8d) | Crystal structures of the kinase domain of AKT2 in complex with ATP-competitive inhibitors | 分子名称: | 4-[2-(4-amino-2,5-dihydro-1,2,5-oxadiazol-3-yl)-6-{[(1S)-3-amino-1-phenylpropyl]oxy}-1-ethyl-1H-imidazo[4,5-c]pyridin-4-yl]-2-methylbut-3-yn-2-ol, Glycogen synthase kinase-3 beta peptide, RAC-beta serine/threonine-protein kinase | 著者 | Concha, N.O, Elkins, P.A, Smallwood, A, Ward, P. | 登録日 | 2008-08-19 | 公開日 | 2008-10-14 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Aminofurazans as potent inhibitors of AKT kinase Bioorg.Med.Chem.Lett., 19, 2009
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8IOY
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![BU of 8ioy by Molmil](/molmil-images/mine/8ioy) | Structure of ATP7B C983S/C985S/D1027A mutant with AMP-PNP | 分子名称: | Copper-transporting ATPase 2, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | 著者 | Yang, G, Xu, L, Guo, J, Wu, Z. | 登録日 | 2023-03-13 | 公開日 | 2023-04-26 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structures of the human Wilson disease copper transporter ATP7B. Cell Rep, 42, 2023
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7YOJ
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![BU of 7yoj by Molmil](/molmil-images/mine/7yoj) | Structure of CasPi with guide RNA and target DNA | 分子名称: | CasPi, DNA (30-MER), DNA (5'-D(P*CP*GP*GP*GP*AP*TP*GP*CP*CP*CP*AP*G)-3'), ... | 著者 | Li, C.P, Wang, J, Liu, J.J. | 登録日 | 2022-08-01 | 公開日 | 2023-02-15 | 最終更新日 | 2024-07-03 | 実験手法 | ELECTRON MICROSCOPY (3.36 Å) | 主引用文献 | The compact Cas pi (Cas12l) 'bracelet' provides a unique structural platform for DNA manipulation. Cell Res., 33, 2023
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6ES1
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8FFE
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![BU of 8ffe by Molmil](/molmil-images/mine/8ffe) | Crystal structure of LRP6 E1E2 domains bound to YW210.09 Fab and engineered XWnt8 peptide | 分子名称: | GLYCEROL, Low-density lipoprotein receptor-related protein 6, SODIUM ION, ... | 著者 | Jude, K.M, Tsutsumi, N, Waghray, D, Garcia, K.C. | 登録日 | 2022-12-08 | 公開日 | 2023-03-08 | 最終更新日 | 2023-03-22 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for coreceptor discrimination. Proc.Natl.Acad.Sci.USA, 120, 2023
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8JM9
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8JMI
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8JMA
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8JME
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8JMH
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5T7V
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![BU of 5t7v by Molmil](/molmil-images/mine/5t7v) | Methicillin Resistant, Linezolid resistant Staphylococcus aureus 70S ribosome (delta S145 uL3) | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Belousoff, M.J, Lithgow, T, Eyal, Z, Yonath, A, Radjainia, M. | 登録日 | 2016-09-06 | 公開日 | 2017-05-31 | 最終更新日 | 2019-12-11 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural Basis for Linezolid Binding Site Rearrangement in theStaphylococcus aureusRibosome. MBio, 8, 2017
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8P01
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![BU of 8p01 by Molmil](/molmil-images/mine/8p01) | Crystal structure of human STING ectodomain in complex with BI 7446, a potent cyclic dinucleotide STING agonist with broad-spectrum variant activity for the treatment of cancer | 分子名称: | 3-[(1~{R},3~{R},6~{R},8~{R},9~{R},10~{R},12~{R},15~{R},17~{R},18~{R})-8-(6-aminopurin-9-yl)-9-fluoranyl-18-oxidanyl-3,12-bis(oxidanylidene)-3,12-bis(sulfanyl)-2,4,7,11,13,16-hexaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-6~{H}-imidazo[4,5-d]pyridazin-7-one, Stimulator of interferon genes protein | 著者 | Nar, H. | 登録日 | 2023-05-09 | 公開日 | 2023-07-26 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.094 Å) | 主引用文献 | Discovery of BI 7446: A Potent Cyclic Dinucleotide STING Agonist with Broad-Spectrum Variant Activity for the Treatment of Cancer. J.Med.Chem., 66, 2023
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