6ES1
Crystal structure of the binding domain from botulinum neurotoxin A2 bound to extracellular domain of human receptor SV2C
Summary for 6ES1
| Entry DOI | 10.2210/pdb6es1/pdb |
| Descriptor | Botulinum neurotoxin type A, Synaptic vesicle glycoprotein 2C, ACETATE ION, ... (4 entities in total) |
| Functional Keywords | receptor, human, clostridium botulinum, binding domain, sv2c, protein binding |
| Biological source | Clostridium botulinum More |
| Cellular location | Botulinum neurotoxin A light chain: Secreted. Botulinum neurotoxin A heavy chain: Secreted: Q45894 Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi- pass membrane protein : Q496J9 |
| Total number of polymer chains | 2 |
| Total formula weight | 65580.88 |
| Authors | Gustafsson, R.,Masuyer, G.,Stenmark, P. (deposition date: 2017-10-19, release date: 2018-04-25, Last modification date: 2024-01-17) |
| Primary citation | Gustafsson, R.,Zhang, S.,Masuyer, G.,Dong, M.,Stenmark, P. Crystal Structure of Botulinum Neurotoxin A2 in Complex with the Human Protein Receptor SV2C Reveals Plasticity in Receptor Binding. Toxins (Basel), 10:-, 2018 Cited by PubMed: 29649119DOI: 10.3390/toxins10040153 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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