6ES1
Crystal structure of the binding domain from botulinum neurotoxin A2 bound to extracellular domain of human receptor SV2C
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Botulinum neurotoxin type A | polymer | 445 | 51643.5 | 1 | UniProt (Q45894) Pfam (PF07953) Pfam (PF07951) | Clostridium botulinum | BoNT/A,Bontoxilysin-A,BOTOX |
| 2 | B (B) | Synaptic vesicle glycoprotein 2C | polymer | 117 | 13878.4 | 1 | UniProt (Q496J9) Pfam (PF13599) | Homo sapiens (Human) | |
| 3 | C (A) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 359 | Chemie (HOH) |
Sequence modifications
A: 874 - 1296 (UniProt: Q45894)
B: 474 - 567 (UniProt: Q496J9)
| PDB | External Database | Details |
|---|---|---|
| Met 852 | - | initiating methionine |
| Gly 853 | - | expression tag |
| Ser 854 | - | expression tag |
| Ser 855 | - | expression tag |
| His 856 | - | expression tag |
| His 857 | - | expression tag |
| His 858 | - | expression tag |
| His 859 | - | expression tag |
| His 860 | - | expression tag |
| His 861 | - | expression tag |
| Ser 862 | - | expression tag |
| Ser 863 | - | expression tag |
| Gly 864 | - | expression tag |
| Glu 865 | - | expression tag |
| Asn 866 | - | expression tag |
| Leu 867 | - | expression tag |
| Tyr 868 | - | expression tag |
| Phe 869 | - | expression tag |
| Gln 870 | - | expression tag |
| Gly 871 | - | expression tag |
| His 872 | - | expression tag |
| Met 873 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Met 451 | - | initiating methionine |
| His 452 | - | expression tag |
| His 453 | - | expression tag |
| His 454 | - | expression tag |
| His 455 | - | expression tag |
| His 456 | - | expression tag |
| His 457 | - | expression tag |
| Ser 458 | - | expression tag |
| Ser 459 | - | expression tag |
| Gly 460 | - | expression tag |
| Val 461 | - | expression tag |
| Asp 462 | - | expression tag |
| Leu 463 | - | expression tag |
| Gly 464 | - | expression tag |
| Thr 465 | - | expression tag |
| Glu 466 | - | expression tag |
| Asn 467 | - | expression tag |
| Leu 468 | - | expression tag |
| Tyr 469 | - | expression tag |
| Phe 470 | - | expression tag |
| Gln 471 | - | expression tag |
| Ser 472 | - | expression tag |
| Met 473 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 65521.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 59.0 | |
| All* | Total formula weight | 65580.9 |
