6ES1
Crystal structure of the binding domain from botulinum neurotoxin A2 bound to extracellular domain of human receptor SV2C
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Botulinum neurotoxin type A | polymer | 445 | 51643.5 | 1 | UniProt (Q45894) Pfam (PF07953) Pfam (PF07951) In PDB | Clostridium botulinum | BoNT/A,Bontoxilysin-A,BOTOX |
2 | B | Synaptic vesicle glycoprotein 2C | polymer | 117 | 13878.4 | 1 | UniProt (Q496J9) Pfam (PF13599) In PDB | Homo sapiens (Human) | |
3 | A | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
4 | water | water | 18.0 | 359 | Chemie (HOH) |
Sequence modifications
A: 874 - 1296 (UniProt: Q45894)
B: 474 - 567 (UniProt: Q496J9)
PDB | External Database | Details |
---|---|---|
Met 852 | - | initiating methionine |
Gly 853 | - | expression tag |
Ser 854 | - | expression tag |
Ser 855 | - | expression tag |
His 856 | - | expression tag |
His 857 | - | expression tag |
His 858 | - | expression tag |
His 859 | - | expression tag |
His 860 | - | expression tag |
His 861 | - | expression tag |
Ser 862 | - | expression tag |
Ser 863 | - | expression tag |
Gly 864 | - | expression tag |
Glu 865 | - | expression tag |
Asn 866 | - | expression tag |
Leu 867 | - | expression tag |
Tyr 868 | - | expression tag |
Phe 869 | - | expression tag |
Gln 870 | - | expression tag |
Gly 871 | - | expression tag |
His 872 | - | expression tag |
Met 873 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met 451 | - | initiating methionine |
His 452 | - | expression tag |
His 453 | - | expression tag |
His 454 | - | expression tag |
His 455 | - | expression tag |
His 456 | - | expression tag |
His 457 | - | expression tag |
Ser 458 | - | expression tag |
Ser 459 | - | expression tag |
Gly 460 | - | expression tag |
Val 461 | - | expression tag |
Asp 462 | - | expression tag |
Leu 463 | - | expression tag |
Gly 464 | - | expression tag |
Thr 465 | - | expression tag |
Glu 466 | - | expression tag |
Asn 467 | - | expression tag |
Leu 468 | - | expression tag |
Tyr 469 | - | expression tag |
Phe 470 | - | expression tag |
Gln 471 | - | expression tag |
Ser 472 | - | expression tag |
Met 473 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 65521.8 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 59.0 | |
All* | Total formula weight | 65580.9 |