5XHS
| Crystal structure of SIRT5 complexed with a fluorogenic small-molecule substrate SuBKA | 分子名称: | (2S)-2-azanyl-6-[(4-hydroxy-4-oxo-butanoyl)amino]hexanoic acid, 7-AMINO-4-METHYL-CHROMEN-2-ONE, NAD-dependent protein deacylase sirtuin-5, ... | 著者 | Yu, Y, Li, B, Chen, Q. | 登録日 | 2017-04-24 | 公開日 | 2018-05-02 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Interactions between sirtuins and fluorogenic small-molecule substrates offer insights into inhibitor design Rsc Adv, 7, 2017
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8HDK
| Structure of the Rat GluN1-GluN2C NMDA receptor in complex with glycine and glutamate (minor class in symmetry) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | 著者 | Zhang, M, Zhang, J, Guo, F, Li, Y, Zhu, S. | 登録日 | 2022-11-04 | 公開日 | 2023-03-29 | 最終更新日 | 2023-05-31 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits. Nat.Struct.Mol.Biol., 30, 2023
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8EZ8
| Structure of 3C08 Fab in complex with A/Moscow/10/1999 (H3N2) influenza virus neuraminidase | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of influenza virus neuraminidase antibody 3C08, Light chain of influenza virus neuraminidase antibody 3C08, ... | 著者 | Mou, Z, Lei, R, Wu, N.C, Dai, X. | 登録日 | 2022-10-31 | 公開日 | 2023-11-08 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.78 Å) | 主引用文献 | Leveraging vaccination-induced protective antibodies to define conserved epitopes on influenza N2 neuraminidase. Immunity, 56, 2023
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8EZ7
| Structure of 1F04 Fab in complex with A/Moscow/10/1999 (H3N2) influenza virus neuraminidase | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of influenza virus neuraminidase antibody 1F04, Light chain of influenza virus neuraminidase antibody 1F04, ... | 著者 | Mou, Z, Lei, R, Wu, N.C, Dai, X. | 登録日 | 2022-10-31 | 公開日 | 2023-11-08 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Leveraging vaccination-induced protective antibodies to define conserved epitopes on influenza N2 neuraminidase. Immunity, 56, 2023
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8EZ3
| Structure of 3A10 Fab in complex with A/Moscow/10/1999 (H3N2) influenza virus neuraminidase | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of influenza virus neuraminidase antibody 3A10, Light chain of influenza virus neuraminidase antibody 3A10, ... | 著者 | Mou, Z, Lei, R, Wu, N.C, Dai, X. | 登録日 | 2022-10-31 | 公開日 | 2023-11-08 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Leveraging vaccination-induced protective antibodies to define conserved epitopes on influenza N2 neuraminidase. Immunity, 56, 2023
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8ETN
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7CYP
| Complex of SARS-CoV-2 spike trimer with its neutralizing antibody HB27 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of HB27, ... | 著者 | Wang, X, Zhu, L. | 登録日 | 2020-09-04 | 公開日 | 2021-06-09 | 最終更新日 | 2022-02-23 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Double lock of a potent human therapeutic monoclonal antibody against SARS-CoV-2. Natl Sci Rev, 8, 2021
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4QO4
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8H3T
| The crystal structure of AlpH | 分子名称: | AlpH, GLYCEROL | 著者 | Zhao, Y, Li, M, Jiang, M, Pan, L.F. | 登録日 | 2022-10-09 | 公開日 | 2023-09-13 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (1.866 Å) | 主引用文献 | O-methyltransferase-like enzyme catalyzed diazo installation in polyketide biosynthesis. Nat Commun, 14, 2023
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6AKW
| Crystal structure of RNA dioxygenase bound with an inhibitor | 分子名称: | 2-OXOGLUTARIC ACID, 2-[[2,6-bis(chloranyl)-4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]amino]benzoic acid, Alpha-ketoglutarate-dependent dioxygenase FTO | 著者 | Yang, C.-G, Huang, Y, Gan, J. | 登録日 | 2018-09-04 | 公開日 | 2019-05-29 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia. Cancer Cell, 35, 2019
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7E5R
| SARS-CoV-2 S trimer with three-antibody cocktail complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, FC05 heavy chain, FC05 light chain, ... | 著者 | Sun, Y, Wang, L, Wang, N, Feng, R, Wang, X. | 登録日 | 2021-02-20 | 公開日 | 2021-10-13 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structure-based development of three- and four-antibody cocktails against SARS-CoV-2 via multiple mechanisms. Cell Res., 31, 2021
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3S36
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8FXU
| Thermoanaerobacter thermosaccharolyticum periplasmic Glucose-Binding Protein glucose complex: Badan conjugate attached at F17C | 分子名称: | 2-bromo-1-[6-(dimethylamino)naphthalen-2-yl]ethan-1-one, CALCIUM ION, CHLORIDE ION, ... | 著者 | Allert, M.J, Kumar, S, Beese, L.S, Hellinga, H.W. | 登録日 | 2023-01-25 | 公開日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | Chromophore carbonyl twisting in fluorescent biosensors encodes direct readout of protein conformations with multicolor switching. Commun Chem, 6, 2023
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7WJ6
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7WJ7
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3S35
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8IFG
| Cryo-EM structure of the Clr6S (Clr6-HDAC) complex from S. pombe | 分子名称: | Chromatin modification-related protein eaf3, Cph1, Cph2, ... | 著者 | Zhang, H.Q, Wang, X, Wang, Y.N, Liu, S.M, Zhang, Y, Xu, K, Ji, L.T, Kornberg, R.D. | 登録日 | 2023-02-17 | 公開日 | 2024-01-03 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Class I histone deacetylase complex: Structure and functional correlates. Proc Natl Acad Sci U S A, 120, 2023
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3S37
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5WPW
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8GI9
| Cation channelrhodopsin from Hyphochytrium catenoides (HcCCR) embedded in peptidisc | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, CHOLESTEROL, Cation Channelrhodopsin, ... | 著者 | Morizumi, T, Kim, K, Li, H, Spudich, J.L, Ernst, O.P. | 登録日 | 2023-03-13 | 公開日 | 2023-07-26 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.84 Å) | 主引用文献 | Structures of channelrhodopsin paralogs in peptidiscs explain their contrasting K + and Na + selectivities. Nat Commun, 14, 2023
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8GI8
| Kalium channelrhodopsin 1 from Hyphochytrium catenoides (HcKCR1) embedded in peptidisc | 分子名称: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, CHOLESTEROL, Kalium Channelrhodopsin 1, ... | 著者 | Morizumi, T, Kim, K, Li, H, Spudich, J.L, Ernst, O.P. | 登録日 | 2023-03-13 | 公開日 | 2023-07-26 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | 主引用文献 | Structures of channelrhodopsin paralogs in peptidiscs explain their contrasting K + and Na + selectivities. Nat Commun, 14, 2023
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8G93
| Crystal structures of 17-beta-hydroxysteroid dehydrogenase 13 | 分子名称: | 3-fluoro-N-({(1r,4r)-4-[(2-fluorophenoxy)methyl]-1-hydroxycyclohexyl}methyl)-4-hydroxybenzamide, Hydroxysteroid 17-beta dehydrogenase 13, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Liu, S. | 登録日 | 2023-02-21 | 公開日 | 2023-08-09 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Structural basis of lipid-droplet localization of 17-beta-hydroxysteroid dehydrogenase 13. Nat Commun, 14, 2023
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8G9V
| Crystal structures of 17-beta-hydroxysteroid dehydrogenase 13 | 分子名称: | 17-beta-hydroxysteroid dehydrogenase 13, 4-{[2,5-dimethyl-3-(4-methylbenzene-1-sulfonyl)benzene-1-sulfonyl]amino}benzoic acid, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ... | 著者 | Liu, S. | 登録日 | 2023-02-22 | 公開日 | 2023-08-09 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.645 Å) | 主引用文献 | Structural basis of lipid-droplet localization of 17-beta-hydroxysteroid dehydrogenase 13. Nat Commun, 14, 2023
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3S34
| Structure of the 1121B Fab fragment | 分子名称: | 1121B Fab heavy chain, 1121B Fab light chain, PHOSPHATE ION | 著者 | Franklin, M.C. | 登録日 | 2011-05-17 | 公開日 | 2011-08-24 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The Structural Basis for the Function of Two Anti-VEGF Receptor 2 Antibodies. Structure, 19, 2011
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7XAF
| The crystal structure of TrkA kinase in complex with 4^6,14-dimethyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-10-oxo-5-oxa-11,14-diaza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclo- tetradecaphan-2-yne-45-carboxamide | 分子名称: | 4^6,14-dimethyl-N-(3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)phenyl)-10-oxo-5-oxa-11,14-diaza-1(3,6)-imidazo[1,2-b]pyridazina-4(1,3)-benzenacyclo-tetradecaphan-2-yne-45-carboxamide, High affinity nerve growth factor receptor | 著者 | Zhang, Z.M, Wang, Y.J. | 登録日 | 2022-03-17 | 公開日 | 2022-06-01 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.001182 Å) | 主引用文献 | Discovery of the First Highly Selective and Broadly Effective Macrocycle-Based Type II TRK Inhibitors that Overcome Clinically Acquired Resistance. J.Med.Chem., 65, 2022
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