6AKW
Crystal structure of RNA dioxygenase bound with an inhibitor
Summary for 6AKW
Entry DOI | 10.2210/pdb6akw/pdb |
Descriptor | Alpha-ketoglutarate-dependent dioxygenase FTO, 2-OXOGLUTARIC ACID, 2-[[2,6-bis(chloranyl)-4-(3,5-dimethyl-1,2-oxazol-4-yl)phenyl]amino]benzoic acid, ... (4 entities in total) |
Functional Keywords | rna demethylase, inhibitor, oxidation, rna binding protein, oxidoreductase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 57048.99 |
Authors | Yang, C.-G.,Huang, Y.,Gan, J. (deposition date: 2018-09-04, release date: 2019-05-29, Last modification date: 2023-11-22) |
Primary citation | Huang, Y.,Su, R.,Sheng, Y.,Dong, L.,Dong, Z.,Xu, H.,Ni, T.,Zhang, Z.S.,Zhang, T.,Li, C.,Han, L.,Zhu, Z.,Lian, F.,Wei, J.,Deng, Q.,Wang, Y.,Wunderlich, M.,Gao, Z.,Pan, G.,Zhong, D.,Zhou, H.,Zhang, N.,Gan, J.,Jiang, H.,Mulloy, J.C.,Qian, Z.,Chen, J.,Yang, C.G. Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia. Cancer Cell, 35:677-691.e10, 2019 Cited by PubMed: 30991027DOI: 10.1016/j.ccell.2019.03.006 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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