8H08
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8H07
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8WIG
| Crystal structure of E. coli ThrS catalytic domain mutant G463S/Q484A | 分子名称: | Threonine--tRNA ligase, ZINC ION | 著者 | Qiao, H, Wang, Z, Wang, J, Fang, P. | 登録日 | 2023-09-24 | 公開日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (3.22 Å) | 主引用文献 | Specific glycine-dependent enzyme motion determines the potency of conformation selective inhibitors of threonyl-tRNA synthetase. Commun Biol, 7, 2024
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8WII
| Crystal structure of E. coli ThrS catalytic domain mutant G463A in complex with Obafluorin | 分子名称: | Threonine--tRNA ligase, ZINC ION, ~{N}-[(2~{R},3~{S})-2-[(4-nitrophenyl)methyl]-4-oxidanylidene-oxetan-3-yl]-2,3-bis(oxidanyl)benzamide | 著者 | Qiao, H, Wang, Z, Wang, J, Fang, P. | 登録日 | 2023-09-24 | 公開日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (2.98 Å) | 主引用文献 | Specific glycine-dependent enzyme motion determines the potency of conformation selective inhibitors of threonyl-tRNA synthetase. Commun Biol, 7, 2024
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8WIJ
| Crystal structure of E. coli ThrS catalytic domain mutant L489M in complex with Obafluorin | 分子名称: | N-(2,3-dihydroxybenzoyl)-4-(4-nitrophenyl)-L-threonine, Threonine--tRNA ligase, ZINC ION | 著者 | Qiao, H, Wang, Z, Wang, J, Fang, P. | 登録日 | 2023-09-24 | 公開日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (3.08 Å) | 主引用文献 | Specific glycine-dependent enzyme motion determines the potency of conformation selective inhibitors of threonyl-tRNA synthetase. Commun Biol, 7, 2024
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8WIA
| Crystal structure of E. coli ThrS catalytic domain mutant G463S | 分子名称: | Threonine--tRNA ligase, ZINC ION | 著者 | Qiao, H, Wang, Z, Wang, J, Fang, P. | 登録日 | 2023-09-24 | 公開日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Specific glycine-dependent enzyme motion determines the potency of conformation selective inhibitors of threonyl-tRNA synthetase. Commun Biol, 7, 2024
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8WIH
| Crystal structure of E. coli ThrS catalytic domain mutant G463A in complex with ATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Threonine--tRNA ligase, ZINC ION | 著者 | Qiao, H, Wang, Z, Wang, J, Fang, P. | 登録日 | 2023-09-24 | 公開日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | 主引用文献 | Specific glycine-dependent enzyme motion determines the potency of conformation selective inhibitors of threonyl-tRNA synthetase. Commun Biol, 7, 2024
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5KQA
| Crystal structure of buckwheat glutaredoxin-glutathione complex | 分子名称: | GLUTATHIONE, Glutaredoxin-glutathione complex | 著者 | Zhang, X, Wang, W, Zhao, Y, Wang, Z, Wang, H. | 登録日 | 2016-07-06 | 公開日 | 2017-07-05 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structural insights into the binding of buckwheat glutaredoxin with GSH and regulation of its catalytic activity J. Inorg. Biochem., 173, 2017
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5J5C
| Crystal structure of ARL1-GTP and DCB domain of BIG1 complex | 分子名称: | ADP-ribosylation factor-like protein 1, Brefeldin A-inhibited guanine nucleotide-exchange protein 1, GUANOSINE-5'-TRIPHOSPHATE, ... | 著者 | Wang, R, Wang, Z, Zhang, T, Ding, J. | 登録日 | 2016-04-02 | 公開日 | 2016-09-28 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Structural basis for targeting BIG1 to Golgi apparatus through interaction of its DCB domain with Arl1 J Mol Cell Biol, 2016
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2VYA
| Crystal Structure of fatty acid amide hydrolase conjugated with the drug-like inhibitor PF-750 | 分子名称: | 4-(quinolin-3-ylmethyl)piperidine-1-carboxylic acid, CHLORIDE ION, FATTY-ACID AMIDE HYDROLASE 1, ... | 著者 | Mileni, M, Johnson, D.S, Wang, Z, Everdeen, D.S, Liimatta, M, Pabst, B, Bhattacharya, K, Nugent, R.A, Kamtekar, S, Cravatt, B.F, Ahn, K, Stevens, R.C. | 登録日 | 2008-07-22 | 公開日 | 2008-09-09 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Structure-Guided Inhibitor Design for Human Faah by Interspecies Active Site Conversion. Proc.Natl.Acad.Sci.USA, 105, 2008
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4DQM
| Revealing a marine natural product as a novel agonist for retinoic acid receptors with a unique binding mode and antitumor activity | 分子名称: | (5S)-4-[(3E,7E)-4,8-dimethyl-10-(2,6,6-trimethylcyclohex-1-en-1-yl)deca-3,7-dien-1-yl]-5-hydroxyfuran-2(5H)-one, Nuclear receptor coactivator 1, Retinoic acid receptor alpha | 著者 | Wang, S, Wang, Z, Lin, S, Zheng, W, Wang, R, Jin, S, Chen, J, Jin, L, Li, Y. | 登録日 | 2012-02-16 | 公開日 | 2012-10-03 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Revealing a natural marine product as a novel agonist for retinoic acid receptors with a unique binding mode and inhibitory effects on cancer cells. Biochem.J., 446, 2012
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6ITM
| Crystal structure of FXR in complex with agonist XJ034 | 分子名称: | 1-adamantyl-[4-(5-chloranyl-2-methyl-phenyl)piperazin-1-yl]methanone, Bile acid receptor, HD3 Peptide from Nuclear receptor coactivator 1 | 著者 | Zhang, H, Wang, Z. | 登録日 | 2018-11-23 | 公開日 | 2019-11-27 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Pose Filter-Based Ensemble Learning Enables Discovery of Orally Active, Nonsteroidal Farnesoid X Receptor Agonists. J.Chem.Inf.Model., 60, 2020
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3NK6
| Structure of the Nosiheptide-resistance methyltransferase | 分子名称: | 23S rRNA methyltransferase | 著者 | Yang, H, Wang, Z, Shen, Y, Wang, P, Murchie, A, Xu, Y. | 登録日 | 2010-06-18 | 公開日 | 2010-07-21 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal Structure of the Nosiheptide-Resistance Methyltransferase of Streptomyces actuosus Biochemistry, 49, 2010
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3NK7
| Structure of the Nosiheptide-resistance methyltransferase S-adenosyl-L-methionine Complex | 分子名称: | 23S rRNA methyltransferase, S-ADENOSYLMETHIONINE | 著者 | Yang, H, Wang, Z, Shen, Y, Wang, P, Murchie, A, Xu, Y. | 登録日 | 2010-06-18 | 公開日 | 2010-07-21 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Crystal Structure of the Nosiheptide-Resistance Methyltransferase of Streptomyces actuosus Biochemistry, 49, 2010
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6O9I
| Ternary complex of mouse ECD with Fab1 and Fab2 | 分子名称: | 1,2-ETHANEDIOL, Fab 2 heavy chain, Fab1 heavy chain, ... | 著者 | Min, X, Wang, Z. | 登録日 | 2019-03-13 | 公開日 | 2020-01-22 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Molecular mechanism of an antagonistic antibody against glucose-dependent insulinotropic polypeptide receptor. Mabs, 12, 2020
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6O9H
| Mouse ECD with Fab1 | 分子名称: | Gastric inhibitory polypeptide receptor, Heavy chain, Light chain, ... | 著者 | Min, X, Wang, Z. | 登録日 | 2019-03-13 | 公開日 | 2020-01-22 | 最終更新日 | 2020-04-01 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Molecular mechanism of an antagonistic antibody against glucose-dependent insulinotropic polypeptide receptor. Mabs, 12, 2020
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6DKJ
| human GIPR ECD and Fab complex | 分子名称: | 1,2-ETHANEDIOL, Fab heavy chain, Fab light chain, ... | 著者 | Min, X, Wang, Z. | 登録日 | 2018-05-29 | 公開日 | 2019-05-08 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models. Sci Transl Med, 10, 2018
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6B8O
| WT Ig-like V Domain with Phosphatidylserine | 分子名称: | 1,2-DICAPROYL-SN-PHOSPHATIDYL-L-SERINE, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Sudom, A, Wang, Z. | 登録日 | 2017-10-09 | 公開日 | 2018-06-27 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2. J. Biol. Chem., 293, 2018
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2YJY
| A specific and modular binding code for cytosine recognition in PUF domains | 分子名称: | 5'-R(*AP*UP*UP*GP*CP*AP*UP*AP*UP*AP)-3', PUMILIO HOMOLOG 1 | 著者 | Dong, S, Wang, Y, Cassidy-Amstutz, C, Lu, G, Qiu, C, Bigler, R, Jezyk, M, Li, C, Hall, T.M.T, Wang, Z. | 登録日 | 2011-05-24 | 公開日 | 2011-06-08 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.598 Å) | 主引用文献 | Specific and Modular Binding Code for Cytosine Recognition in Pumilio/Fbf (Puf) RNA-Binding Domains. J.Biol.Chem., 286, 2011
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4CSU
| Cryo-EM structures of the 50S ribosome subunit bound with ObgE | 分子名称: | 23S RRNA, 50S RIBOSOMAL PROTEIN L1, 50S RIBOSOMAL PROTEIN L11, ... | 著者 | Feng, B, Mandava, C.S, Guo, Q, Wang, J, Cao, W, Li, N, Zhang, Y, Zhang, Y, Wang, Z, Wu, J, Sanyal, S, Lei, J, Gao, N. | 登録日 | 2014-03-10 | 公開日 | 2014-06-04 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (5.5 Å) | 主引用文献 | Structural and Functional Insights Into the Mode of Action of a Universally Conserved Obg Gtpase. Plos Biol., 12, 2014
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8Q4G
| Thin filament from FIB milled relaxed left ventricular mouse myofibrils | 分子名称: | Actin, alpha cardiac muscle 1, Tropomyosin alpha-1 chain | 著者 | Tamborrini, D, Wang, Z, Wagner, T, Tacke, S, Stabrin, M, Grange, M, Kho, A.L, Bennet, P, Rees, M, Gautel, M, Raunser, S. | 登録日 | 2023-08-06 | 公開日 | 2023-11-01 | 最終更新日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (8 Å) | 主引用文献 | Structure of the native myosin filament in the relaxed cardiac sarcomere. Nature, 623, 2023
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3BZU
| Crystal structure of human 11-beta-hydroxysteroid dehydrogenase(HSD1) in complex with NADP and thiazolone inhibitor | 分子名称: | (5S)-2-{[(1S)-1-(2-fluorophenyl)ethyl]amino}-5-methyl-5-(trifluoromethyl)-1,3-thiazol-4(5H)-one, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Min, X, Sudom, A, Xu, H, Wang, Z, Walker, N.P. | 登録日 | 2008-01-18 | 公開日 | 2008-06-10 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Structural characterization and pharmacodynamic effects of an orally active 11beta-hydroxysteroid dehydrogenase type 1 inhibitor. Chem.Biol.Drug Des., 71, 2008
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5JMT
| Crystal structure of Zika virus NS3 helicase | 分子名称: | NS3 helicase | 著者 | Tian, H, Ji, X, Yang, X, Xie, W, Yang, K, Chen, C, Wu, C, Chi, H, Mu, Z, Wang, Z, Yang, H. | 登録日 | 2016-04-29 | 公開日 | 2016-05-25 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.796 Å) | 主引用文献 | The crystal structure of Zika virus helicase: basis for antiviral drug design Protein Cell, 7, 2016
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5LZB
| Structure of SelB-Sec-tRNASec bound to the 70S ribosome in the initial binding state (IB) | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Fischer, N, Neumann, P, Bock, L.V, Maracci, C, Wang, Z, Paleskava, A, Konevega, A.L, Schroeder, G.F, Grubmueller, H, Ficner, R, Rodnina, M.V, Stark, H. | 登録日 | 2016-09-29 | 公開日 | 2016-11-23 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (5.3 Å) | 主引用文献 | The pathway to GTPase activation of elongation factor SelB on the ribosome. Nature, 540, 2016
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5LZF
| Structure of the 70S ribosome with fMetSec-tRNASec in the hybrid pre-translocation state (H) | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Fischer, N, Neumann, P, Bock, L.V, Maracci, C, Wang, Z, Paleskava, A, Konevega, A.L, Schroeder, G.F, Grubmueller, H, Ficner, R, Rodnina, M.V, Stark, H. | 登録日 | 2016-09-29 | 公開日 | 2016-11-23 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | 主引用文献 | The pathway to GTPase activation of elongation factor SelB on the ribosome. Nature, 540, 2016
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