6DKJ

human GIPR ECD and Fab complex

Summary for 6DKJ

• Entry DOI: 10.2210/pdb6dkj/pdb
• Descriptor: Fab heavy chain, Fab light chain, Gastric inhibitory polypeptide receptor, ... (5 entities in total)
• Functional Keywords: gpcr, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 121046.82

Authors

Min, X.,Wang, Z. (deposition date: 2018-05-29, release date: 2019-05-08)

• Primary citation: Killion, E.A.,Wang, J.,Yie, J.,Shi, S.D.,Bates, D.,Min, X.,Komorowski, R.,Hager, T.,Deng, L.,Atangan, L.,Lu, S.C.,Kurzeja, R.J.M.,Sivits, G.,Lin, J.,Chen, Q.,Wang, Z.,Thibault, S.A.,Abbott, C.M.,Meng, T.,Clavette, B.,Murawsky, C.M.,Foltz, I.N.,Rottman, J.B.,Hale, C.,Veniant, M.M.,Lloyd, D.J.; Anti-obesity effects of GIPR antagonists alone and in combination with GLP-1R agonists in preclinical models.; Sci Transl Med, 10:-, 2018; PubMed: 30567927; DOI: 10.1126/scitranslmed.aat3392

Experimental method

X-RAY DIFFRACTION (1.95 Å)