1E5H
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![BU of 1e5h by Molmil](/molmil-images/mine/1e5h) | DELTA-R307A DEACETOXYCEPHALOSPORIN C SYNTHASE COMPLEXED WITH SUCCINATE AND CARBON DIOXIDE | 分子名称: | CARBON DIOXIDE, DEACETOXYCEPHALOSPORIN C SYNTHASE, FE (II) ION, ... | 著者 | Lee, H.J, Lloyd, M.D, Harlos, K, Clifton, I.J, Baldwin, J.E, Schofield, C.J. | 登録日 | 2000-07-26 | 公開日 | 2001-07-26 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Kinetic and Crystallographic Studies on Deacetoxycephalosporin C Synthase (Daocs) J.Mol.Biol., 308, 2001
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2QC9
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2Y34
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7WKV
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![BU of 7wkv by Molmil](/molmil-images/mine/7wkv) | Crystal structure of human ALKBH5 in complex with 2-oxoglutarate (2OG) and m6A-containing ssRNA | 分子名称: | 2-OXOGLUTARIC ACID, MANGANESE (II) ION, RNA (5'-R(P*GP*GP*(6MZ)P*C)-3'), ... | 著者 | Kaur, S, McDonough, M.A, Schofield, C.J, Aik, W.S. | 登録日 | 2022-01-11 | 公開日 | 2022-03-30 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Mechanisms of substrate recognition and N6-methyladenosine demethylation revealed by crystal structures of ALKBH5-RNA complexes. Nucleic Acids Res., 50, 2022
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2Y33
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7WL0
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![BU of 7wl0 by Molmil](/molmil-images/mine/7wl0) | Crystal structure of human ALKBH5 in complex with N-oxalylglycine (NOG) and m6A-containing ssRNA | 分子名称: | FORMIC ACID, MANGANESE (II) ION, N-OXALYLGLYCINE, ... | 著者 | Kaur, S, McDonough, M.A, Schofield, C.J, Aik, W.S. | 登録日 | 2022-01-12 | 公開日 | 2022-03-30 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Mechanisms of substrate recognition and N6-methyladenosine demethylation revealed by crystal structures of ALKBH5-RNA complexes. Nucleic Acids Res., 50, 2022
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5LY2
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![BU of 5ly2 by Molmil](/molmil-images/mine/5ly2) | JMJD2A/ KDM4A COMPLEXED WITH NI(II), NOG AND Macrocyclic PEPTIDE Inhibitor CP2_R6Kme3 (13-mer) | 分子名称: | CHLORIDE ION, CP2_R6Kme3, GLYCEROL, ... | 著者 | Chowdhury, R, Madden, S.K, Hopkinson, R, Schofield, C.J. | 登録日 | 2016-09-23 | 公開日 | 2017-04-12 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | 主引用文献 | Highly selective inhibition of histone demethylases by de novo macrocyclic peptides. Nat Commun, 8, 2017
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5LY1
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![BU of 5ly1 by Molmil](/molmil-images/mine/5ly1) | JMJD2A/ KDM4A COMPLEXED WITH NI(II) AND Macrocyclic PEPTIDE Inhibitor CP2 (13-mer) | 分子名称: | CHLORIDE ION, CP2, GLYCEROL, ... | 著者 | King, O.N.F, Chowdhury, R, Kawamura, A, Schofield, C.J. | 登録日 | 2016-09-23 | 公開日 | 2017-04-12 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Highly selective inhibition of histone demethylases by de novo macrocyclic peptides. Nat Commun, 8, 2017
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6ST3
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![BU of 6st3 by Molmil](/molmil-images/mine/6st3) | HIF prolyl hydroxylase 2 (PHD2/ EGLN1) in complex with 4-hydroxy-N-(4-phenoxybenzyl)-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamide | 分子名称: | 4-oxidanyl-~{N}-[(4-phenoxyphenyl)methyl]-2-pyrazol-1-yl-pyrimidine-5-carboxamide, Egl nine homolog 1, FORMIC ACID, ... | 著者 | Chowdhury, R, Holt-Martyn, J.P, Schofield, C.J. | 登録日 | 2019-09-10 | 公開日 | 2019-12-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.426 Å) | 主引用文献 | Structure-Activity Relationship and Crystallographic Studies on 4-Hydroxypyrimidine HIF Prolyl Hydroxylase Domain Inhibitors. Chemmedchem, 15, 2020
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1HJG
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![BU of 1hjg by Molmil](/molmil-images/mine/1hjg) | Alteration of the co-substrate selectivity of deacetoxycephalosporin C synthase: The role of arginine-258 | 分子名称: | 3-METHYL-2-OXOBUTANOIC ACID, DEACETOXYCEPHALOSPORIN C SYNTHASE, FE (II) ION | 著者 | Lee, H.J, Lloyd, M.D, Clifton, I.J, Harlos, K, Dubus, A, Baldwin, J.E, Frere, J.M, Schofield, C.J. | 登録日 | 2001-01-15 | 公開日 | 2001-06-01 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Alteration of the 2-Oxoacid Cosubstrate Selectivity in Deacetoxycephalosporin C Synthase: The Role of Arginine-258 J.Biol.Chem., 276, 2001
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1HJF
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![BU of 1hjf by Molmil](/molmil-images/mine/1hjf) | Alteration of the co-substrate selectivity of deacetoxycephalosporin C synthase: The role of arginine-258 | 分子名称: | 2-OXO-4-METHYLPENTANOIC ACID, DEACETOXYCEPHALOSPORIN C SYNTHASE, FE (II) ION | 著者 | Lee, H.J, Lloyd, M.D, Clifton, I.J, Harlos, K, Dubus, A, Baldwin, J.E, Frere, J.M, Schofield, C.J. | 登録日 | 2001-01-15 | 公開日 | 2001-06-01 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Alteration of the 2-Oxoacid Cosubstrate Selectivity in Deacetoxycephalosporin C Synthase: The Role of Arginine-258 J.Biol.Chem., 276, 2001
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2OS2
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![BU of 2os2 by Molmil](/molmil-images/mine/2os2) | Crystal structure of JMJD2A complexed with histone H3 peptide trimethylated at Lys36 | 分子名称: | JmjC domain-containing histone demethylation protein 3A, N-OXALYLGLYCINE, NICKEL (II) ION, ... | 著者 | Kavanagh, K.L, Ng, S.S, Pilka, E, McDonough, M.A, Savitsky, P, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A, Sundstrom, M, Schofield, C.J, Oppermann, U, Structural Genomics Consortium (SGC) | 登録日 | 2007-02-05 | 公開日 | 2007-03-13 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity. Nature, 448, 2007
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2OT7
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![BU of 2ot7 by Molmil](/molmil-images/mine/2ot7) | Crystal structure of JMJD2A complexed with histone H3 peptide monomethylated at Lys9 | 分子名称: | JmjC domain-containing histone demethylation protein 3A, N-OXALYLGLYCINE, NICKEL (II) ION, ... | 著者 | Kavanagh, K.L, Ng, S.S, Pilka, E, McDonough, M.A, Savitsky, P, von Delft, F, Arrowsmith, C.H, Weigelt, J, Edwards, A, Sundstrom, M, Schofield, C.J, Oppermann, U, Structural Genomics Consortium (SGC) | 登録日 | 2007-02-07 | 公開日 | 2007-03-13 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.135 Å) | 主引用文献 | Crystal structures of histone demethylase JMJD2A reveal basis for substrate specificity. Nature, 448, 2007
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2BRT
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![BU of 2brt by Molmil](/molmil-images/mine/2brt) | ANTHOCYANIDIN SYNTHASE FROM ARABIDOPSIS THALIANA COMPLEXED with naringenin | 分子名称: | 2-OXOGLUTARIC ACID, FE (II) ION, LEUCOANTHOCYANIDIN DIOXYGENASE, ... | 著者 | Turnbull, J.J, Clifton, I.J, Welford, R.W.D, Schofield, C.J. | 登録日 | 2005-05-11 | 公開日 | 2006-08-29 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural and Mechanistic Studies on Anthocyanidin Synthase Catalysed Oxidation of Flavanone Substrates: The Effect of C-2 Stereochemistry on Product Selectivity and Mechanism Org.Biomol.Chem., 3, 2005
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2CGO
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![BU of 2cgo by Molmil](/molmil-images/mine/2cgo) | FACTOR INHIBITING HIF-1 ALPHA with fumarate | 分子名称: | FE (III) ION, FUMARIC ACID, HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR, ... | 著者 | McDonough, M.A, Clifton, I.J, Schofield, C.J. | 登録日 | 2006-03-09 | 公開日 | 2006-12-13 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural and Mechanistic Studies on the Inhibition of the Hypoxia-Inducible Transcription Factor Hydroxylases by Tricarboxylic Acid Cycle Intermediates. J.Biol.Chem., 282, 2007
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2CGN
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![BU of 2cgn by Molmil](/molmil-images/mine/2cgn) | FACTOR INHIBITING HIF-1 ALPHA with succinate | 分子名称: | FE (III) ION, HYPOXIA-INDUCIBLE FACTOR 1 ALPHA INHIBITOR, SUCCINIC ACID, ... | 著者 | McDonough, M.A, Clifton, I.J, Schofield, C.J. | 登録日 | 2006-03-09 | 公開日 | 2006-12-13 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structural and Mechanistic Studies on the Inhibition of the Hypoxia-Inducible Transcription Factor Hydroxylases by Tricarboxylic Acid Cycle Intermediates. J.Biol.Chem., 282, 2007
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2G1M
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3T4H
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![BU of 3t4h by Molmil](/molmil-images/mine/3t4h) | Crystal Structure of AlkB in complex with Fe(III) and N-Oxalyl-S-(3-nitrobenzyl)-L-cysteine | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Alpha-ketoglutarate-dependent dioxygenase AlkB, FE (III) ION, ... | 著者 | Ma, J, Aik, W.S, McDonough, M.A, Schofield, C.J. | 登録日 | 2011-07-26 | 公開日 | 2012-03-07 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic Acid demethylase. J.Med.Chem., 55, 2012
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4CUG
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![BU of 4cug by Molmil](/molmil-images/mine/4cug) | Rhodothermus marinus YCFD-like ribosomal protein L16 Arginyl hydroxylase in complex substrate fragment | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 50S RIBOSOMAL PROTEIN L16, CUPIN 4 FAMILY PROTEIN, ... | 著者 | McDonough, M.A, Sekirnik, R, Schofield, C.J. | 登録日 | 2014-03-18 | 公開日 | 2014-04-16 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.96 Å) | 主引用文献 | Ribosomal oxygenases are structurally conserved from prokaryotes to humans. Nature, 510, 2014
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4CWD
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![BU of 4cwd by Molmil](/molmil-images/mine/4cwd) | CRYSTAL STRUCTURE OF HUMAN GAMMA-BUTYROBETAINE,2-OXOGLUTARATE IN COMPLEX WITH 449, A NOVEL SUBSTRATE | 分子名称: | 4-carboxy-1,1-dimethylpiperidin-1-ium, DI(HYDROXYETHYL)ETHER, GAMMA-BUTYROBETAINE DIOXYGENASE, ... | 著者 | McDonough, M.A, Kochan, G, Rydzik, A, Schofield, C.J. | 登録日 | 2014-04-02 | 公開日 | 2014-09-17 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.899 Å) | 主引用文献 | Oxygenase-catalyzed desymmetrization of N,N-dialkyl-piperidine-4-carboxylic acids. Angew. Chem. Int. Ed. Engl., 53, 2014
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3RVH
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![BU of 3rvh by Molmil](/molmil-images/mine/3rvh) | Crystal Structure of JMJD2A Complexed with Inhibitor | 分子名称: | 8-hydroxy-3-(piperazin-1-yl)quinoline-5-carboxylic acid, GLYCEROL, Lysine-specific demethylase 4A, ... | 著者 | King, O.N.F, Maloney, D.J, Tumber, A, Rai, G, Jadhav, A, Clifton, I.J, Heightman, T.D, Simeonov, A, McDonough, M.A, Schofield, C.J. | 登録日 | 2011-05-06 | 公開日 | 2012-05-09 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.251 Å) | 主引用文献 | Crystal Structure of JMJD2A Complexed with Inhibitor To be Published
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3T3Y
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3T4V
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![BU of 3t4v by Molmil](/molmil-images/mine/3t4v) | Crystal Structure of AlkB in complex with Fe(III) and N-Oxalyl-S-(2-napthalenemethyl)-L-cysteine | 分子名称: | Alpha-ketoglutarate-dependent dioxygenase AlkB, FE (III) ION, GLYCEROL, ... | 著者 | Aik, W.S, McDonough, M.A, Schofield, C.J. | 登録日 | 2011-07-26 | 公開日 | 2012-03-07 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.732 Å) | 主引用文献 | Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic Acid demethylase. J.Med.Chem., 55, 2012
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3U4S
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![BU of 3u4s by Molmil](/molmil-images/mine/3u4s) | Histone Lysine demethylase JMJD2A in complex with T11C peptide substrate crosslinked to N-oxalyl-D-cysteine | 分子名称: | HISTONE 3 TAIL ANALOG (T11C Peptide), Lysine-specific demethylase 4A, N-(carboxycarbonyl)-D-cysteine, ... | 著者 | Ma, J, McDonough, M.A, Schofield, C.J. | 登録日 | 2011-10-10 | 公開日 | 2012-02-08 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Linking of 2-Oxoglutarate and Substrate Binding Sites Enables Potent and Highly Selective Inhibition of JmjC Histone Demethylases. Angew.Chem.Int.Ed.Engl., 51, 2012
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4CHL
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![BU of 4chl by Molmil](/molmil-images/mine/4chl) | Human Ethylmalonic Encephalopathy Protein 1 (hETHE1) | 分子名称: | FE (III) ION, PERSULFIDE DIOXYGENASE ETHE1, MITOCHONDRIAL | 著者 | Pettinati, I, Brem, J, McDonough, M.A, Schofield, C.J. | 登録日 | 2013-12-03 | 公開日 | 2014-12-17 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | 主引用文献 | Crystal structure of human persulfide dioxygenase: structural basis of ethylmalonic encephalopathy. Hum. Mol. Genet., 24, 2015
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