3T3Y

Crystal structure of AlkB in complex with Fe(III) and 2-(3-hydroxypicolinomido)acetic acid

Summary for 3T3Y

Entry DOI	10.2210/pdb3t3y/pdb
Related	2FD8 2FDF 2FDG 2FDH 2FDI 2FDJ 2FDK 3BI3 3BIE 3BKZ 3H8O 3H8R 3H8X 3I2O 3I3M 3I3Q 3I49 3KHB 3KHC 3O1M 3O1O 3O1P 3O1R 3O1S 3O1T 3O1U 3O1V 3T4H 3T4V
Descriptor	Alpha-ketoglutarate-dependent dioxygenase AlkB, FE (III) ION, N-[(3-hydroxypyridin-2-yl)carbonyl]glycine, ... (4 entities in total)
Functional Keywords	double-stranded beta-helix, nucleic acid demethylase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	23197.24
Authors	Aik, W.S.,McDonough, M.A.,Schofield, C.J. (deposition date: 2011-07-25, release date: 2012-03-07, Last modification date: 2023-09-13)
Primary citation	Woon, E.C.,Demetriades, M.,Bagg, E.A.,Aik, W.,Krylova, S.M.,Ma, J.H.,Chan, M.,Walport, L.J.,Wegman, D.W.,Dack, K.N.,McDonough, M.A.,Krylov, S.N.,Schofield, C.J. Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic Acid demethylase. J.Med.Chem., 55:2173-2184, 2012 Cited by PubMed: 22263962 DOI: 10.1021/jm201417e PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.001 Å)

Structure validation