3T4H
Crystal Structure of AlkB in complex with Fe(III) and N-Oxalyl-S-(3-nitrobenzyl)-L-cysteine
Summary for 3T4H
Entry DOI | 10.2210/pdb3t4h/pdb |
Related | 2FD8 2FDF 2FDG 2FDH 2FDI 2FDJ 2FDK 3BI3 3BIE 3BKZ 3H8O 3H8R 3H8X 3I2O 3I3M 3I3Q 3I49 3KHB 3KHC 3O1M 3O1O 3O1P 3O1R 3O1S 3O1T 3O1U 3O1V 3T3Y 3T4V |
Descriptor | Alpha-ketoglutarate-dependent dioxygenase AlkB, FE (III) ION, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... (5 entities in total) |
Functional Keywords | double-stranded beta-helix, nucleic acid demethylase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Escherichia coli |
Total number of polymer chains | 1 |
Total formula weight | 23567.68 |
Authors | Ma, J.,Aik, W.S.,McDonough, M.A.,Schofield, C.J. (deposition date: 2011-07-26, release date: 2012-03-07, Last modification date: 2024-02-28) |
Primary citation | Woon, E.C.,Demetriades, M.,Bagg, E.A.,Aik, W.,Krylova, S.M.,Ma, J.H.,Chan, M.,Walport, L.J.,Wegman, D.W.,Dack, K.N.,McDonough, M.A.,Krylov, S.N.,Schofield, C.J. Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic Acid demethylase. J.Med.Chem., 55:2173-2184, 2012 Cited by PubMed: 22263962DOI: 10.1021/jm201417e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.65 Å) |
Structure validation
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