6T7L
Crystal structure of AmpC from E.coli with Nacubactam (OP0595)
Summary for 6T7L
| Entry DOI | 10.2210/pdb6t7l/pdb |
| Descriptor | Beta-lactamase, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, (2S,5R)-N-(2-aminoethoxy)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, ... (8 entities in total) |
| Functional Keywords | beta lactamase, antibiotic resistance, diazabicyclooctane, dbo, hydrolase |
| Biological source | Escherichia coli K-12 |
| Total number of polymer chains | 1 |
| Total formula weight | 40521.99 |
| Authors | Lang, P.A.,Leissing, T.M.,Schofield, C.J.,Brem, J. (deposition date: 2019-10-22, release date: 2020-11-18, Last modification date: 2024-01-24) |
| Primary citation | Lang, P.A.,Leissing, T.M.,Page, M.G.P.,Schofield, C.J.,Brem, J. Structural Investigations of the Inhibition of Escherichia coli AmpC beta-Lactamase by Diazabicyclooctanes. Antimicrob.Agents Chemother., 65:-, 2021 Cited by PubMed: 33199391DOI: 10.1128/AAC.02073-20 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.47 Å) |
Structure validation
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