3CVF
 
 | | Crystal Structure of the carboxy terminus of Homer3 | | 分子名称: | Homer protein homolog 3 | | 著者 | Hayashi, M.K, Stearns, M.H, Giannini, V, Xu, R.-M, Sala, C, Hayashi, Y. | | 登録日 | 2008-04-18 | | 公開日 | 2009-03-31 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | The postsynaptic density proteins Homer and Shank form a polymeric network structure.
Cell(Cambridge,Mass.), 137, 2009
|
|
3L5T
 | |
1IQC
 | |
3CVE
 | | Crystal Structure of the carboxy terminus of Homer1 | | 分子名称: | Homer protein homolog 1 | | 著者 | Hayashi, M.K, Stearns, M.H, Giannini, V, Xu, R.-M, Sala, C, Hayashi, Y. | | 登録日 | 2008-04-18 | | 公開日 | 2009-03-31 | | 最終更新日 | 2021-10-20 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | The postsynaptic density proteins Homer and Shank form a polymeric network structure.
Cell(Cambridge,Mass.), 137, 2009
|
|
3CVR
 | |
8DKS
 | | IRAK4 IN COMPLEX WITH COMPOUND #3 | | 分子名称: | (1S,2S,3R,4R)-3-({2-[3-(pyrrolidine-1-carbonyl)anilino]thieno[3,2-d]pyrimidin-4-yl}amino)bicyclo[2.2.1]hept-5-ene-2-carboxamide, BETA-MERCAPTOETHANOL, Interleukin-1 receptor-associated kinase 4 | | 著者 | Chen, Y, Lin, N. | | 登録日 | 2022-07-06 | | 公開日 | 2022-08-03 | | 最終更新日 | 2022-08-17 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Bicyclic pyrimidine compounds as potent IRAK4 inhibitors.
Bioorg.Med.Chem.Lett., 73, 2022
|
|
3L5R
 | |
3L5U
 | |
3L5S
 | |
8CVN
 | | Cryo-EM Structure of Human 15-PGDH in Complex with Small Molecule SW209415 | | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 15-hydroxyprostaglandin dehydrogenase [NAD(+)], 2-[butyl(oxidanyl)-$l^{3}-sulfanyl]-4-(2,3-dimethylimidazol-4-yl)-6-(1,3-thiazol-2-yl)thieno[2,3-b]pyridin-3-amine | | 著者 | Huang, W, Taylor, D.J. | | 登録日 | 2022-05-18 | | 公開日 | 2023-03-01 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | | 主引用文献 | Small molecule inhibitors of 15-PGDH exploit a physiologic induced-fit closing system.
Nat Commun, 14, 2023
|
|
8CWL
 | |
3L5V
 | |
3L5P
 | |
8WUY
 | | Crystal Structure of TR3 LBD in complex with para-positioned 3,4,5-trisubstituted benzene derivatives | | 分子名称: | Nuclear receptor subfamily 4immunitygroup A member 1, ~{N}-methyl-~{N}-octyl-3,4,5-tris(oxidanyl)benzamide | | 著者 | Hong, W.B, Chen, X.Q, Lin, T.W. | | 登録日 | 2023-10-21 | | 公開日 | 2024-01-24 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure-based design and synthesis of anti-fibrotic compounds derived from para-positioned 3,4,5-trisubstituted benzene.
Bioorg.Chem., 144, 2024
|
|
5H5P
 | |
8DMH
 | | Lymphocytic choriomeningitis virus glycoprotein in complex with neutralizing antibody M28 | | 分子名称: | 18.5C-M28 Fab Heavy Chain, 18.5C-M28 Fab Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Moon-Walker, A, Hastie, K.M, Zyla, D.S, Saphire, E.O. | | 登録日 | 2022-07-08 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-05-03 | | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | | 主引用文献 | Structural basis for antibody-mediated neutralization of lymphocytic choriomeningitis virus.
Cell Chem Biol, 30, 2023
|
|
8DMI
 | | Lymphocytic choriomeningitis virus glycoprotein | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein G1, ... | | 著者 | Moon-Walker, A, Hastie, K.M, Zyla, D.S, Saphire, E.O. | | 登録日 | 2022-07-08 | | 公開日 | 2023-04-12 | | 最終更新日 | 2023-05-03 | | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | | 主引用文献 | Structural basis for antibody-mediated neutralization of lymphocytic choriomeningitis virus.
Cell Chem Biol, 30, 2023
|
|
8IS5
 | |
8IS4
 | | Structure of an Isocytosine specific deaminase Vcz in complexed with 5-FU | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5-FLUOROURACIL, GLYCEROL, ... | | 著者 | Guo, W.T, Li, X.J, Wu, B.X. | | 登録日 | 2023-03-20 | | 公開日 | 2023-08-30 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural characterization of an isocytosine-specific deaminase VCZ reveals its application potential in the anti-cancer therapy.
Iscience, 26, 2023
|
|
5X5P
 | | Human serum transferrin bound to ruthenium NTA | | 分子名称: | FE (III) ION, MALONATE ION, NITRILOTRIACETIC ACID, ... | | 著者 | Sun, H, Wang, M. | | 登録日 | 2017-02-17 | | 公開日 | 2018-02-21 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Binding of ruthenium and osmium at non‐iron sites of transferrin accounts for their iron-independent cellular uptake.
J.Inorg.Biochem., 234, 2022
|
|
6VXG
 | | Structure of the C-terminal Domain of RAGE and Its Inhibitor | | 分子名称: | Advanced glycosylation end product-specific receptor, N-(4-{7-cyano-4-[(morpholin-4-yl)methyl]quinolin-2-yl}phenyl)acetamide | | 著者 | Ramirez, L, Shekhtman, A. | | 登録日 | 2020-02-21 | | 公開日 | 2021-02-24 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Small-molecule antagonism of the interaction of the RAGE cytoplasmic domain with DIAPH1 reduces diabetic complications in mice.
Sci Transl Med, 13, 2021
|
|
3F4M
 | | Crystal structure of TIPE2 | | 分子名称: | CHLORIDE ION, Tumor necrosis factor, alpha-induced protein 8-like protein 2 | | 著者 | Zhang, X, Wang, J, Shi, Y. | | 登録日 | 2008-11-01 | | 公開日 | 2009-03-17 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.696 Å) | | 主引用文献 | Crystal structure of TIPE2 provides insights into immune homeostasis
Nat.Struct.Mol.Biol., 16, 2009
|
|
7CBQ
 | | Crystal structure of PDE4D catalytic domain in complex with Apremilast | | 分子名称: | 1,2-ETHANEDIOL, MAGNESIUM ION, N-{2-[(1S)-1-(3-ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide, ... | | 著者 | Zhang, X.L, Xu, Y.C. | | 登録日 | 2020-06-13 | | 公開日 | 2021-01-27 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | | 主引用文献 | Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment.
Eur.J.Med.Chem., 211, 2021
|
|
7CBJ
 | | Crystal structure of PDE4D catalytic domain in complex with compound 36 | | 分子名称: | (1S)-1-[(7-chloranyl-1H-indol-3-yl)methyl]-6,7-dimethoxy-3,4-dihydro-1H-isoquinoline-2-carbaldehyde, 1,2-ETHANEDIOL, MAGNESIUM ION, ... | | 著者 | Zhang, X.L, Xu, Y.C. | | 登録日 | 2020-06-12 | | 公開日 | 2021-06-16 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment.
Eur.J.Med.Chem., 211, 2021
|
|
5ZVD
 | |
