8IS4

Structure of an Isocytosine specific deaminase Vcz in complexed with 5-FU

Summary for 8IS4

• Entry DOI: 10.2210/pdb8is4/pdb
• Related: 7ww2
• Descriptor: Hydroxydechloroatrazine ethylaminohydrolase, 5-FLUOROURACIL, ZINC ION, ... (6 entities in total)
• Functional Keywords: isocytosine, deaminase, vcz, 5-fu, hydrolase
• Biological source: Obesumbacterium proteus
• Total number of polymer chains: 2
• Total formula weight: 99693.93

Authors

Guo, W.T.,Li, X.J.,Wu, B.X. (deposition date: 2023-03-20, release date: 2023-08-30, Last modification date: 2023-09-20)

• Primary citation: Guo, W.,Li, X.,Fan, J.,Li, H.,Wen, Y.,Meng, C.,Chen, H.,Zhao, Z.,Zhang, Y.,Du, Y.,Wu, B.; Structural characterization of an isocytosine-specific deaminase VCZ reveals its application potential in the anti-cancer therapy.; Iscience, 26:107672-107672, 2023; PubMed: 37680460; DOI: 10.1016/j.isci.2023.107672

Experimental method

X-RAY DIFFRACTION (1.9 Å)