7CBQ
Crystal structure of PDE4D catalytic domain in complex with Apremilast
Summary for 7CBQ
Entry DOI | 10.2210/pdb7cbq/pdb |
Descriptor | cAMP-specific 3',5'-cyclic phosphodiesterase 4D, MAGNESIUM ION, ZINC ION, ... (6 entities in total) |
Functional Keywords | pde4d, inhibitor, complex structure, metal binding protein, hydrolase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 82000.19 |
Authors | Zhang, X.L.,Xu, Y.C. (deposition date: 2020-06-13, release date: 2021-01-27, Last modification date: 2023-11-29) |
Primary citation | Zhang, R.,Li, H.,Zhang, X.,Li, J.,Su, H.,Lu, Q.,Dong, G.,Dou, H.,Fan, C.,Gu, Z.,Mu, Q.,Tang, W.,Xu, Y.,Liu, H. Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment. Eur.J.Med.Chem., 211:113004-113004, 2021 Cited by PubMed: 33218684DOI: 10.1016/j.ejmech.2020.113004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.59 Å) |
Structure validation
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