7CBJ

Crystal structure of PDE4D catalytic domain in complex with compound 36

Summary for 7CBJ

• Entry DOI: 10.2210/pdb7cbj/pdb
• Descriptor: cAMP-specific 3',5'-cyclic phosphodiesterase 4D, ZINC ION, MAGNESIUM ION, ... (6 entities in total)
• Functional Keywords: pde4d, inhibitor, complex structure, metal binding protein, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 81886.67

Authors

Zhang, X.L.,Xu, Y.C. (deposition date: 2020-06-12, release date: 2021-06-16, Last modification date: 2023-11-29)

• Primary citation: Zhang, R.,Li, H.,Zhang, X.,Li, J.,Su, H.,Lu, Q.,Dong, G.,Dou, H.,Fan, C.,Gu, Z.,Mu, Q.,Tang, W.,Xu, Y.,Liu, H.; Design, synthesis, and biological evaluation of tetrahydroisoquinolines derivatives as novel, selective PDE4 inhibitors for antipsoriasis treatment.; Eur.J.Med.Chem., 211:113004-113004, 2021; PubMed: 33218684; DOI: 10.1016/j.ejmech.2020.113004

Experimental method

X-RAY DIFFRACTION (1.5 Å)