3WGW
 
 | | Structure of PCNA bound to a small molecule inhibitor | | 分子名称: | 4-{4-[(2S)-2-amino-3-hydroxypropyl]-2,6-diiodophenoxy}phenol, Proliferating cell nuclear antigen, SULFATE ION | | 著者 | Hashimoto, H. | | 登録日 | 2013-08-12 | | 公開日 | 2014-02-05 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | A small molecule inhibitor of monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) inhibits repair of interstrand DNA cross-link, enhances DNA double strand break, and sensitizes cancer cells to cisplatin.
J.Biol.Chem., 289, 2014
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2DDD
 | | Unique behavior of a histidine responsible for an engineered green-to-red photoconversion process | | 分子名称: | MAGNESIUM ION, SODIUM ION, photoconvertible fluorescent protein | | 著者 | Shimizu, H, Tsutsui, H, Nukina, N, Miyawaki, A. | | 登録日 | 2006-01-27 | | 公開日 | 2006-03-07 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | The E1 mechanism in photo-induced beta-elimination reactions for green-to-red conversion of fluorescent proteins
Chem.Biol., 16, 2009
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2DDC
 | | Unique behavior of a histidine responsible for an engineered green-to-red photoconversion process | | 分子名称: | MAGNESIUM ION, SODIUM ION, photoconvertible fluorescent protein | | 著者 | Shimizu, H, Tsutsui, H, Nukina, N, Miyawaki, A. | | 登録日 | 2006-01-27 | | 公開日 | 2006-03-07 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | The E1 mechanism in photo-induced beta-elimination reactions for green-to-red conversion of fluorescent proteins.
Chem.Biol., 16, 2009
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1HZY
 | | HIGH RESOLUTION STRUCTURE OF THE ZINC-CONTAINING PHOSPHOTRIESTERASE FROM PSEUDOMONAS DIMINUTA | | 分子名称: | 1,2-ETHANEDIOL, 2-PHENYL-ETHANOL, FORMIC ACID, ... | | 著者 | Holden, H.M, Benning, M.M, Raushel, F.M, Shim, H. | | 登録日 | 2001-01-26 | | 公開日 | 2001-04-04 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | High resolution X-ray structures of different metal-substituted forms of phosphotriesterase from Pseudomonas diminuta.
Biochemistry, 40, 2001
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1I0B
 | | HIGH RESOLUTION STRUCTURE OF THE MANGANESE-CONTAINING PHOSPHOTRIESTERASE FROM PSEUDOMONAS DIMINUTA | | 分子名称: | 1,2-ETHANEDIOL, 2-PHENYL-ETHANOL, FORMIC ACID, ... | | 著者 | Holden, H.M, Benning, M.M, Raushel, F.M, Shim, H. | | 登録日 | 2001-01-29 | | 公開日 | 2001-04-04 | | 最終更新日 | 2019-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | High resolution X-ray structures of different metal-substituted forms of phosphotriesterase from Pseudomonas diminuta.
Biochemistry, 40, 2001
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1I0D
 | | HIGH RESOLUTION STRUCTURE OF THE ZINC/CADMIUM-CONTAINING PHOSPHOTRIESTERASE FROM PSEUDOMONAS DIMINUTA | | 分子名称: | 1,2-ETHANEDIOL, 2-PHENYL-ETHANOL, CADMIUM ION, ... | | 著者 | Holden, H.M, Benning, M.M, Raushel, F.M, Shim, H. | | 登録日 | 2001-01-29 | | 公開日 | 2001-04-04 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | High resolution X-ray structures of different metal-substituted forms of phosphotriesterase from Pseudomonas diminuta.
Biochemistry, 40, 2001
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1JGM
 | | High Resolution Structure of the Cadmium-containing Phosphotriesterase from Pseudomonas diminuta | | 分子名称: | 1,2-ETHANEDIOL, 2-PHENYL-ETHANOL, CADMIUM ION, ... | | 著者 | Benning, M.M, Shim, H, Raushel, F.M, Holden, H.M. | | 登録日 | 2001-06-26 | | 公開日 | 2001-07-04 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | High resolution X-ray structures of different metal-substituted forms of phosphotriesterase from Pseudomonas diminuta.
Biochemistry, 40, 2001
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8RXR
 | | Crystal structure of VPS34 in complex with inhibitor SB02024 | | 分子名称: | 4-[(3R)-3-methylmorpholin-4-yl]-2-[(2R)-2-(trifluoromethyl)piperidin-1-yl]-3H-pyridin-6-one, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | | 著者 | Tresaugues, L, Yu, Y, Bogdan, M, Parpal, S, Silvander, C, Lindstrom, J, Simeon, J, Timson, M.J, Al-Hashimi, H, Smith, B.D, Flynn, D.L, Viklund, J, Martinsson, J, De Milito, A, Andersson, M. | | 登録日 | 2024-02-07 | | 公開日 | 2024-03-20 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (2.06 Å) | | 主引用文献 | Combining VPS34 inhibitors with STING agonists enhances type I interferon signaling and anti-tumor efficacy.
Mol Oncol, 2024
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3A8R
 | | The structure of the N-terminal regulatory domain of a plant NADPH oxidase | | 分子名称: | CALCIUM ION, Putative uncharacterized protein | | 著者 | Oda, T, Hashimoto, H, Kuwabara, N, Akashi, S, Hayashi, K, Kojima, C, Wong, H.L, Kawasaki, T, Shimamoto, K, Sato, M, Shimizu, T. | | 登録日 | 2009-10-07 | | 公開日 | 2009-10-27 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | The structure of the N-terminal regulatory domain of a plant NADPH oxidase and its functional implications
J.Biol.Chem., 285, 2010
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1MK8
 | | Crystal Structure of a Mutant Cytochrome c Peroxidase showing a Novel Trp-Tyr Covalent Cross-link | | 分子名称: | Cytochrome c Peroxidase, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Bhaskar, B, Immoos, C.E, Shimizu, H, Farmer, P.J, Poulos, T.L. | | 登録日 | 2002-08-28 | | 公開日 | 2003-04-08 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | A Novel Heme and Peroxide-Dependent Tryptophan-Tyrosine Cross-Link in a Mutant of Cytochrome c Peroxidase
J.Mol.Biol., 328, 2003
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1MKQ
 | | Crystal Structure of the Mutant Variant of Cytochrome c Peroxidase in the 'Open' Uncross-linked form | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Cytochrome c Peroxidase, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Bhaskar, B, Immoos, C.E, Shimizu, H, Farmer, P.J, Poulos, T.L. | | 登録日 | 2002-08-29 | | 公開日 | 2003-04-08 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | | 主引用文献 | A Novel Heme and Peroxide-Dependent Tryptophan-Tyrosine Cross-Link in a Mutant of Cytochrome c Peroxidase
J.Mol.Biol., 328, 2003
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7XZR
 | | Crystal structure of TNIK-AMPPNP-thiopeptide TP15 complex | | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SULFATE ION, ... | | 著者 | Hamada, K, Vinogradov, A.A, Zhang, Y, Chang, J.S, Nishimura, H, Goto, Y, Onaka, H, Suga, H, Ogata, K, Sengoku, T. | | 登録日 | 2022-06-03 | | 公開日 | 2022-10-26 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | De Novo Discovery of Thiopeptide Pseudo-natural Products Acting as Potent and Selective TNIK Kinase Inhibitors.
J.Am.Chem.Soc., 144, 2022
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7XZQ
 | | Crystal structure of TNIK-thiopeptide TP1 complex | | 分子名称: | 1,4-BUTANEDIOL, TRAF2 and NCK-interacting protein kinase, thiopeptide TP1 | | 著者 | Hamada, K, Vinogradov, A.A, Zhang, Y, Chang, J.S, Nishimura, H, Goto, Y, Onaka, H, Suga, H, Ogata, K, Sengoku, T. | | 登録日 | 2022-06-03 | | 公開日 | 2022-10-26 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | De Novo Discovery of Thiopeptide Pseudo-natural Products Acting as Potent and Selective TNIK Kinase Inhibitors.
J.Am.Chem.Soc., 144, 2022
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5H6L
 | | DNA targeting ADP-ribosyltransferase Pierisin-1 in complex with beta-NAD+ | | 分子名称: | 1,2-ETHANEDIOL, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Pierisin-1 | | 著者 | Oda, T, Hirabayashi, H, Shikauchi, G, Takamura, R, Hiraga, K, Minami, H, Hashimoto, H, Yamamoto, M, Wakabayashi, K, Sugimura, T, Shimizu, T, Sato, M. | | 登録日 | 2016-11-14 | | 公開日 | 2017-08-09 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural basis of autoinhibition and activation of the DNA-targeting ADP-ribosyltransferase pierisin-1
J. Biol. Chem., 292, 2017
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5H6M
 | | DNA targeting ADP-ribosyltransferase Pierisin-1 | | 分子名称: | 1,2-ETHANEDIOL, Pierisin-1 | | 著者 | Oda, T, Hirabayashi, H, Shikauchi, G, Takamura, R, Hiraga, K, Minami, H, Hashimoto, H, Yamamoto, M, Wakabayashi, K, Sugimura, T, Shimizu, T, Sato, M. | | 登録日 | 2016-11-14 | | 公開日 | 2017-08-09 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural basis of autoinhibition and activation of the DNA-targeting ADP-ribosyltransferase pierisin-1
J. Biol. Chem., 292, 2017
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3J3Z
 | | Structure of MA28-7 neutralizing antibody Fab fragment from electron cryo-microscopy of enterovirus 71 complexed with a Fab fragment | | 分子名称: | MA28-7 neutralizing antibody heavy chain, MA28-7 neutralizing antibody light chain | | 著者 | Lee, H, Cifuente, J.O, Ashley, R.E, Conway, J.F, Makhov, A.M, Tano, Y, Shimizu, H, Nishimura, Y, Hafenstein, S. | | 登録日 | 2013-05-21 | | 公開日 | 2013-08-28 | | 最終更新日 | 2018-07-18 | | 実験手法 | ELECTRON MICROSCOPY (23.4 Å) | | 主引用文献 | A strain-specific epitope of enterovirus 71 identified by cryo-electron microscopy of the complex with fab from neutralizing antibody.
J.Virol., 87, 2013
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5H6J
 | | DNA targeting ADP-ribosyltransferase Pierisin-1 in complex with beta-NAD+ | | 分子名称: | NICOTINAMIDE-ADENINE-DINUCLEOTIDE, Pierisin-1 | | 著者 | Oda, T, Hirabayashi, H, Shikauchi, G, Takamura, R, Hiraga, K, Minami, H, Hashimoto, H, Yamamoto, M, Wakabayashi, K, Sugimura, T, Shimizu, T, Sato, M. | | 登録日 | 2016-11-14 | | 公開日 | 2017-08-09 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural basis of autoinhibition and activation of the DNA-targeting ADP-ribosyltransferase pierisin-1
J. Biol. Chem., 292, 2017
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5H6K
 | | DNA targeting ADP-ribosyltransferase Pierisin-1 | | 分子名称: | 1,2-ETHANEDIOL, Pierisin-1 | | 著者 | Oda, T, Hirabayashi, H, Shikauchi, G, Takamura, R, Hiraga, K, Minami, H, Hashimoto, H, Yamamoto, M, Wakabayashi, K, Sugimura, T, Shimizu, T, Sato, M. | | 登録日 | 2016-11-14 | | 公開日 | 2017-08-09 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural basis of autoinhibition and activation of the DNA-targeting ADP-ribosyltransferase pierisin-1
J. Biol. Chem., 292, 2017
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5H6N
 | | DNA targeting ADP-ribosyltransferase Pierisin-1, autoinhibitory form | | 分子名称: | Pierisin-1 | | 著者 | Oda, T, Hirabayashi, H, Shikauchi, G, Takamura, R, Hiraga, K, Minami, H, Hashimoto, H, Yamamoto, M, Wakabayashi, K, Sugimura, T, Shimizu, T, Sato, M. | | 登録日 | 2016-11-14 | | 公開日 | 2017-08-09 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural basis of autoinhibition and activation of the DNA-targeting ADP-ribosyltransferase pierisin-1
J. Biol. Chem., 292, 2017
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6KR6
 | | Crystal structure of Drosophila Piwi | | 分子名称: | MERCURY (II) ION, Protein piwi, ZINC ION, ... | | 著者 | Yamaguchi, S, Oe, A, Yamashita, K, Hirano, S, Mastumoto, N, Ishitani, R, Nishimasu, H, Nureki, O. | | 登録日 | 2019-08-21 | | 公開日 | 2020-02-19 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Crystal structure of Drosophila Piwi.
Nat Commun, 11, 2020
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1GE9
 | | SOLUTION STRUCTURE OF THE RIBOSOME RECYCLING FACTOR | | 分子名称: | RIBOSOME RECYCLING FACTOR | | 著者 | Yoshida, T, Uchiyama, S, Nakano, H, Kashimori, H, Kijima, H, Ohshima, T, Saihara, Y, Ishino, T, Shimahara, T, Yoshida, T, Yokose, K, Ohkubo, T, Kaji, A, Kobayashi, Y. | | 登録日 | 2000-10-19 | | 公開日 | 2001-05-16 | | 最終更新日 | 2023-12-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution structure of the ribosome recycling factor from Aquifex aeolicus.
Biochemistry, 40, 2001
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3VLA
 | | Crystal structure of edgp | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, EDGP | | 著者 | Yoshizawa, T, Shimizu, T, Hirano, H, Sato, M, Hashimoto, H. | | 登録日 | 2011-11-30 | | 公開日 | 2012-04-18 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (0.95 Å) | | 主引用文献 | Structural basis for inhibition of xyloglucan-specific endo-beta-1,4-glucanase (XEG) by XEG-protein inhibitor
J.Biol.Chem., 287, 2012
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3VLB
 | | Crystal structure of xeg-edgp | | 分子名称: | EDGP, Xyloglucan-specific endo-beta-1,4-glucanase A | | 著者 | Yoshizawa, T, Shimizu, T, Hirano, H, Sato, M, Hashimoto, H. | | 登録日 | 2011-11-30 | | 公開日 | 2012-04-18 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural basis for inhibition of xyloglucan-specific endo-beta-1,4-glucanase (XEG) by XEG-protein inhibitor
J.Biol.Chem., 287, 2012
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6KBC
 | | Crystal structure of CghA with Sch210972 | | 分子名称: | (2S)-3-[(2S,4E)-4-[[(1R,2S,4aR,6S,8R,8aS)-2-[(E)-but-2-en-2-yl]-6,8-dimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]-oxidanyl-methylidene]-3,5-bis(oxidanylidene)pyrrolidin-2-yl]-2-methyl-2-oxidanyl-propanoic acid, CghA | | 著者 | Hara, K, Hashimoto, H, Maeda, N, Sato, M, Watanabe, K. | | 登録日 | 2019-06-24 | | 公開日 | 2020-06-24 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | Catalytic mechanism and endo-to-exo selectivity reversion of an octalin-forming natural Diels-Alderase
Nat Catal, 2021
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6KJG
 | | Crystal structure of PsoF | | 分子名称: | Dual-functional monooxygenase/methyltransferase psoF | | 著者 | Hara, K, Hashimoto, H, Matsushita, T, Tsunematsu, Y, Watanabe, K. | | 登録日 | 2019-07-22 | | 公開日 | 2019-09-18 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | Functional and Structural Analyses oftrans C-Methyltransferase in Fungal Polyketide Biosynthesis.
Biochemistry, 58, 2019
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