5G3U
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![BU of 5g3u by Molmil](/molmil-images/mine/5g3u) | The structure of the L-tryptophan oxidase VioA from Chromobacterium violaceum in complex with its inhibitor 2-(1H-indol-3-ylmethyl)prop-2- enoic acid | 分子名称: | 2-[(1H-indol-3-yl)methyl]prop-2-enoic acid, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, GLYCEROL, ... | 著者 | Krausze, J, Rabe, J, Moser, J. | 登録日 | 2016-05-01 | 公開日 | 2016-08-03 | 最終更新日 | 2019-05-08 | 実験手法 | X-RAY DIFFRACTION (2.377 Å) | 主引用文献 | Biosynthesis of Violacein, Structure and Function of l-Tryptophan Oxidase VioA from Chromobacterium violaceum. J.Biol.Chem., 291, 2016
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7OOX
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![BU of 7oox by Molmil](/molmil-images/mine/7oox) | Crystal structure of PIM1 in complex with ARC-3126 | 分子名称: | 1,2-ETHANEDIOL, Inhibitor ARC-3126, PHOSPHATE ION, ... | 著者 | Chaikuad, A, Dixon-Clarke, S.E, Nonga, O.E, Uri, A, Bullock, A, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2021-05-28 | 公開日 | 2021-08-04 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Crystal Structure-Guided Design of Bisubstrate Inhibitors and Photoluminescent Probes for Protein Kinases of the PIM Family. Molecules, 26, 2021
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7OOV
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![BU of 7oov by Molmil](/molmil-images/mine/7oov) | Crystal structure of PIM1 in complex with ARC-1411 | 分子名称: | 1,2-ETHANEDIOL, Inhibitor ARC-1411, SULFATE ION, ... | 著者 | Chaikuad, A, Dixon-Clarke, S.E, Nonga, O.E, Uri, A, Bullock, A, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2021-05-28 | 公開日 | 2021-08-04 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Crystal Structure-Guided Design of Bisubstrate Inhibitors and Photoluminescent Probes for Protein Kinases of the PIM Family. Molecules, 26, 2021
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7OOW
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![BU of 7oow by Molmil](/molmil-images/mine/7oow) | Crystal structure of PIM1 in complex with ARC-1415 | 分子名称: | 1,2-ETHANEDIOL, INHIBITOR ARC-1415, MAGNESIUM ION, ... | 著者 | Chaikuad, A, Dixon-Clarke, S.E, Nonga, O.E, Uri, A, Bullock, A, Knapp, S, Structural Genomics Consortium (SGC) | 登録日 | 2021-05-28 | 公開日 | 2021-08-04 | 最終更新日 | 2024-04-10 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Crystal Structure-Guided Design of Bisubstrate Inhibitors and Photoluminescent Probes for Protein Kinases of the PIM Family. Molecules, 26, 2021
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6XUE
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6XUG
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6XUQ
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6NTS
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![BU of 6nts by Molmil](/molmil-images/mine/6nts) | Protein Phosphatase 2A (Aalpha-B56alpha-Calpha) holoenzyme in complex with a Small Molecule Activator of PP2A (SMAP) | 分子名称: | MANGANESE (II) ION, N-[(1R,2R,3S)-2-hydroxy-3-(10H-phenoxazin-10-yl)cyclohexyl]-4-(trifluoromethoxy)benzene-1-sulfonamide, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform, ... | 著者 | Huang, W, Taylor, D. | 登録日 | 2019-01-30 | 公開日 | 2020-05-06 | 最終更新日 | 2023-11-15 | 実験手法 | ELECTRON MICROSCOPY (3.63 Å) | 主引用文献 | Selective PP2A Enhancement through Biased Heterotrimer Stabilization. Cell, 181, 2020
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6Z9B
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6NX1
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![BU of 6nx1 by Molmil](/molmil-images/mine/6nx1) | STRUCTURE OF HUMAN PREGNANE X RECEPTOR LIGAND BINDING DOMAIN BOUND TETHERED WITH SRC CO-ACTIVATOR PEPTIDE AND COMPOUND-3 AKA 1,1,1,3,3,3-HEXAFLUORO-2-{4-[1-(4- LUOROBENZENESULFONYL)CYCLOPENTYL]PHENYL}PROPAN-2-OL | 分子名称: | 1,1,1,3,3,3-hexafluoro-2-(4-{1-[(4-fluorophenyl)sulfonyl]cyclopentyl}phenyl)propan-2-ol, Nuclear receptor subfamily 1 group I member 2,Nuclear receptor coactivator 1 fusion | 著者 | Khan, J.A. | 登録日 | 2019-02-07 | 公開日 | 2020-02-12 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | 主引用文献 | Structure-based Discovery of Phenyl (3-Phenylpyrrolidin-3-yl)sulfones as Selective, Orally Active ROR gamma t Inverse Agonists. Acs Med.Chem.Lett., 10, 2019
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6NY4
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8P0M
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![BU of 8p0m by Molmil](/molmil-images/mine/8p0m) | Crystal structure of TEAD3 in complex with IAG933 | 分子名称: | 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, 4-[(2~{S})-5-chloranyl-6-fluoranyl-2-phenyl-2-[(2~{S})-pyrrolidin-2-yl]-3~{H}-1-benzofuran-4-yl]-5-fluoranyl-6-(2-hydroxyethyloxy)-~{N}-methyl-pyridine-3-carboxamide, DIMETHYL SULFOXIDE, ... | 著者 | Scheufler, C, Villard, F, Chau, S. | 登録日 | 2023-05-10 | 公開日 | 2024-04-10 | 最終更新日 | 2024-04-17 | 実験手法 | X-RAY DIFFRACTION (1.961 Å) | 主引用文献 | Direct and selective pharmacological disruption of the YAP-TEAD interface by IAG933 inhibits Hippo-dependent and RAS-MAPK-altered cancers. Nat Cancer, 2024
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7QGM
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7QGL
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7QGO
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![BU of 7qgo by Molmil](/molmil-images/mine/7qgo) | Human CD73 (ecto 5'-nucleotidase) in complex with MRS4602 (a 3-methyl-CMPCP derivative, compound 21 in paper) in the closed state (crystal form III) | 分子名称: | 5'-nucleotidase, ZINC ION, [[(2~{R},3~{S},4~{R},5~{R})-5-[(4~{E})-4-[(4-methoxycarbonylphenyl)methoxyimino]-3-methyl-2-oxidanylidene-pyrimidin-1-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]methylphosphonic acid | 著者 | Strater, N. | 登録日 | 2021-12-09 | 公開日 | 2022-02-16 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.206 Å) | 主引用文献 | Structure-Activity Relationship of 3-Methylcytidine-5'-alpha , beta-methylenediphosphates as CD73 Inhibitors. J.Med.Chem., 65, 2022
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7QGA
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3Q9U
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![BU of 3q9u by Molmil](/molmil-images/mine/3q9u) | In silico and in vitro co-evolution of a high affinity complementary protein-protein interface | 分子名称: | COENZYME A, CoA binding protein, consensus ankyrin repeat | 著者 | Karanicolas, J, Corn, J.E, Chen, I, Joachimiak, L.A, Dym, O, Chung, S, Albeck, S, Unger, T, Hu, W, Liu, G, Delbecq, S, Montelione, G.T, Spiegel, C, Liu, D, Baker, D, Israel Structural Proteomics Center (ISPC) | 登録日 | 2011-01-10 | 公開日 | 2011-04-20 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | A de novo protein binding pair by computational design and directed evolution. Mol.Cell, 42, 2011
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6R5K
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3Q9N
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![BU of 3q9n by Molmil](/molmil-images/mine/3q9n) | In silico and in vitro co-evolution of a high affinity complementary protein-protein interface | 分子名称: | CARBAMOYL SARCOSINE, COENZYME A, CoA binding protein, ... | 著者 | Karanicolas, J, Corn, J.E, Chen, I, Joachimiak, L.A, Dym, O, Chung, S, Albeck, S, Unger, T, Hu, W, Liu, G, Delbecq, S, Montelione, G.T, Spiegel, C, Liu, D, Baker, D, Israel Structural Proteomics Center (ISPC) | 登録日 | 2011-01-09 | 公開日 | 2011-04-27 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A de novo protein binding pair by computational design and directed evolution. Mol.Cell, 42, 2011
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1P8X
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4M8J
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![BU of 4m8j by Molmil](/molmil-images/mine/4m8j) | Crystal structure of CaiT R262E bound to gamma-butyrobetaine | 分子名称: | 3-CARBOXY-N,N,N-TRIMETHYLPROPAN-1-AMINIUM, L-carnitine/gamma-butyrobetaine antiporter | 著者 | Kalayil, S. | 登録日 | 2013-08-13 | 公開日 | 2013-10-09 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.294 Å) | 主引用文献 | Arginine oscillation explains Na+ independence in the substrate/product antiporter CaiT. Proc.Natl.Acad.Sci.USA, 110, 2013
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5GSA
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![BU of 5gsa by Molmil](/molmil-images/mine/5gsa) | EED in complex with an allosteric PRC2 inhibitor | 分子名称: | Histone-lysine N-methyltransferase EZH2, N-(furan-2-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, Polycomb protein EED | 著者 | Zhao, K, Zhao, M, Luo, X, Zhang, H. | 登録日 | 2016-08-15 | 公開日 | 2017-02-01 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of Nat. Chem. Biol., 13, 2017
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4QIF
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![BU of 4qif by Molmil](/molmil-images/mine/4qif) | Crystal Structure of PduA with edge mutation K26A and pore mutation S40H | 分子名称: | D(-)-TARTARIC ACID, GLYCEROL, POTASSIUM ION, ... | 著者 | Pang, A.H, Sawaya, M.R, Yeates, T.O. | 登録日 | 2014-05-30 | 公開日 | 2015-02-18 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.9951 Å) | 主引用文献 | Selective molecular transport through the protein shell of a bacterial microcompartment organelle. Proc.Natl.Acad.Sci.USA, 112, 2015
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8P01
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![BU of 8p01 by Molmil](/molmil-images/mine/8p01) | Crystal structure of human STING ectodomain in complex with BI 7446, a potent cyclic dinucleotide STING agonist with broad-spectrum variant activity for the treatment of cancer | 分子名称: | 3-[(1~{R},3~{R},6~{R},8~{R},9~{R},10~{R},12~{R},15~{R},17~{R},18~{R})-8-(6-aminopurin-9-yl)-9-fluoranyl-18-oxidanyl-3,12-bis(oxidanylidene)-3,12-bis(sulfanyl)-2,4,7,11,13,16-hexaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecan-17-yl]-6~{H}-imidazo[4,5-d]pyridazin-7-one, Stimulator of interferon genes protein | 著者 | Nar, H. | 登録日 | 2023-05-09 | 公開日 | 2023-07-26 | 最終更新日 | 2024-06-19 | 実験手法 | X-RAY DIFFRACTION (2.094 Å) | 主引用文献 | Discovery of BI 7446: A Potent Cyclic Dinucleotide STING Agonist with Broad-Spectrum Variant Activity for the Treatment of Cancer. J.Med.Chem., 66, 2023
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4QIG
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