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6XUQ

Human Ecto-5'-nucleotidase (CD73) in complex with A1618 (compound 1b in publication) in the closed state in crystal form III

Summary for 6XUQ
Entry DOI10.2210/pdb6xuq/pdb
Descriptor5'-nucleotidase, ZINC ION, CALCIUM ION, ... (5 entities in total)
Functional Keywordsnon-nucleotide inhibitor, hydrolase, arcus biosciences
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight62452.79
Authors
Strater, N. (deposition date: 2020-01-20, release date: 2020-04-22, Last modification date: 2024-01-24)
Primary citationBeatty, J.W.,Lindsey, E.A.,Thomas-Tran, R.,Debien, L.,Mandal, D.,Jeffrey, J.L.,Tran, A.T.,Fournier, J.,Jacob, S.D.,Yan, X.,Drew, S.L.,Ginn, E.,Chen, A.,Pham, A.T.,Zhao, S.,Jin, L.,Young, S.W.,Walker, N.P.,Leleti, M.R.,Moschutz, S.,Strater, N.,Powers, J.P.,Lawson, K.V.
Discovery of Potent and Selective Non-Nucleotide Small Molecule Inhibitors of CD73.
J.Med.Chem., 63:3935-3955, 2020
Cited by
PubMed: 32212732
DOI: 10.1021/acs.jmedchem.9b01713
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.97 Å)
Structure validation

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