6JT2
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![BU of 6jt2 by Molmil](/molmil-images/mine/6jt2) | Structure of human soluble guanylate cyclase in the NO activated state | 分子名称: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, MAGNESIUM ION, ... | 著者 | Chen, L, Kang, Y, Liu, R, Wu, J.-X. | 登録日 | 2019-04-08 | 公開日 | 2019-09-04 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Structural insights into the mechanism of human soluble guanylate cyclase. Nature, 574, 2019
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6JT0
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![BU of 6jt0 by Molmil](/molmil-images/mine/6jt0) | Structure of human soluble guanylate cyclase in the unliganded state | 分子名称: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Chen, L, Kang, Y, Liu, R, Wu, J.-X. | 登録日 | 2019-04-08 | 公開日 | 2019-08-28 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Structural insights into the mechanism of human soluble guanylate cyclase. Nature, 574, 2019
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6JT1
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![BU of 6jt1 by Molmil](/molmil-images/mine/6jt1) | Structure of human soluble guanylate cyclase in the heme oxidised state | 分子名称: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, PROTOPORPHYRIN IX CONTAINING FE | 著者 | Chen, L, Kang, Y, Liu, R, Wu, J.-X. | 登録日 | 2019-04-08 | 公開日 | 2019-08-28 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structural insights into the mechanism of human soluble guanylate cyclase. Nature, 574, 2019
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7VLS
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![BU of 7vls by Molmil](/molmil-images/mine/7vls) | Structure of SUR2B in complex with MgATP/ADP and P1075 | 分子名称: | 1-cyano-2-(2-methylbutan-2-yl)-3-pyridin-3-yl-guanidine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Chen, L, Ding, D. | 登録日 | 2021-10-05 | 公開日 | 2022-05-18 | 最終更新日 | 2022-12-14 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural identification of vasodilator binding sites on the SUR2 subunit. Nat Commun, 13, 2022
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7VLT
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![BU of 7vlt by Molmil](/molmil-images/mine/7vlt) | Structure of SUR2B in complex with Mg-ATP/ADP and levcromakalim | 分子名称: | (3S,4R)-2,2-dimethyl-3-oxidanyl-4-(2-oxidanylidenepyrrolidin-1-yl)-3,4-dihydrochromene-6-carbonitrile, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Chen, L, Ding, D. | 登録日 | 2021-10-05 | 公開日 | 2022-05-18 | 最終更新日 | 2022-12-14 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural identification of vasodilator binding sites on the SUR2 subunit. Nat Commun, 13, 2022
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7VLU
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![BU of 7vlu by Molmil](/molmil-images/mine/7vlu) | Structure of SUR2A in complex with Mg-ATP/ADP and P1075 | 分子名称: | 1-cyano-2-(2-methylbutan-2-yl)-3-pyridin-3-yl-guanidine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Chen, L, Ding, D. | 登録日 | 2021-10-05 | 公開日 | 2022-05-18 | 最終更新日 | 2022-12-14 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural identification of vasodilator binding sites on the SUR2 subunit. Nat Commun, 13, 2022
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7VLR
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![BU of 7vlr by Molmil](/molmil-images/mine/7vlr) | Structure of SUR2B in complex with Mg-ATP/ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL HEMISUCCINATE, ... | 著者 | Chen, L, Ding, D. | 登録日 | 2021-10-05 | 公開日 | 2022-05-18 | 最終更新日 | 2022-12-14 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural identification of vasodilator binding sites on the SUR2 subunit. Nat Commun, 13, 2022
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7E24
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![BU of 7e24 by Molmil](/molmil-images/mine/7e24) | |
7E28
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![BU of 7e28 by Molmil](/molmil-images/mine/7e28) | |
7VSI
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![BU of 7vsi by Molmil](/molmil-images/mine/7vsi) | Structure of human SGLT2-MAP17 complex bound with empagliflozin | 分子名称: | (2S,3R,4R,5S,6R)-2-[4-chloranyl-3-[[4-[(3S)-oxolan-3-yl]oxyphenyl]methyl]phenyl]-6-(hydroxymethyl)oxane-3,4,5-triol, PALMITIC ACID, PDZK1-interacting protein 1, ... | 著者 | Chen, L, Niu, Y, Liu, R. | 登録日 | 2021-10-26 | 公開日 | 2021-12-15 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (2.95 Å) | 主引用文献 | Structural basis of inhibition of the human SGLT2-MAP17 glucose transporter. Nature, 601, 2022
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7D4Q
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![BU of 7d4q by Molmil](/molmil-images/mine/7d4q) | Structure of human TRPC5 in complex with HC-070 | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 8-(3-chloranylphenoxy)-7-[(4-chlorophenyl)methyl]-3-methyl-1-(3-oxidanylpropyl)purine-2,6-dione, CALCIUM ION, ... | 著者 | Chen, L, Song, K, Wei, M, Guo, W. | 登録日 | 2020-09-24 | 公開日 | 2021-03-31 | 最終更新日 | 2021-10-13 | 実験手法 | ELECTRON MICROSCOPY (2.74 Å) | 主引用文献 | Structural basis for human TRPC5 channel inhibition by two distinct inhibitors. Elife, 10, 2021
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7D4P
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![BU of 7d4p by Molmil](/molmil-images/mine/7d4p) | Structure of human TRPC5 in complex with clemizole | 分子名称: | (2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole, ... | 著者 | Chen, L, Song, K, Wei, M, Guo, W. | 登録日 | 2020-09-24 | 公開日 | 2021-03-31 | 最終更新日 | 2021-10-13 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural basis for human TRPC5 channel inhibition by two distinct inhibitors. Elife, 10, 2021
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7Y4S
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![BU of 7y4s by Molmil](/molmil-images/mine/7y4s) | |
7E4T
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![BU of 7e4t by Molmil](/molmil-images/mine/7e4t) | Human TRPC5 apo state structure at 3 angstrom | 分子名称: | (2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, ... | 著者 | Chen, L, Song, K, Wei, M, Guo, W. | 登録日 | 2021-02-15 | 公開日 | 2021-03-31 | 最終更新日 | 2021-10-13 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis for human TRPC5 channel inhibition by two distinct inhibitors. Elife, 10, 2021
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7W7G
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![BU of 7w7g by Molmil](/molmil-images/mine/7w7g) | |
7W4O
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![BU of 7w4o by Molmil](/molmil-images/mine/7w4o) | The structure of KATP H175K mutant in pre-open state | 分子名称: | 6-chloranyl-~{N}-(1-methylcyclopropyl)-1,1-bis(oxidanylidene)-4~{H}-thieno[3,2-e][1,2,4]thiadiazin-3-amine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Chen, L, Wang, M. | 登録日 | 2021-11-28 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | 主引用文献 | Structural insights into the mechanism of pancreatic K ATP channel regulation by nucleotides. Nat Commun, 13, 2022
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7W4P
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![BU of 7w4p by Molmil](/molmil-images/mine/7w4p) | The structure of KATP H175K mutant in closed state | 分子名称: | 6-chloranyl-~{N}-(1-methylcyclopropyl)-1,1-bis(oxidanylidene)-4~{H}-thieno[3,2-e][1,2,4]thiadiazin-3-amine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | 著者 | Chen, L, Wang, M. | 登録日 | 2021-11-28 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | 主引用文献 | Structural insights into the mechanism of pancreatic K ATP channel regulation by nucleotides. Nat Commun, 13, 2022
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7WDB
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![BU of 7wdb by Molmil](/molmil-images/mine/7wdb) | Human TRPC5 channel in complex with riluzole | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine, CALCIUM ION, ... | 著者 | Chen, L, Wei, M, Yang, Y. | 登録日 | 2021-12-21 | 公開日 | 2022-04-13 | 最終更新日 | 2022-08-03 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Structural identification of riluzole-binding site on human TRPC5. Cell Discov, 8, 2022
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7WMV
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![BU of 7wmv by Molmil](/molmil-images/mine/7wmv) | Structure of human SGLT1-MAP17 complex bound with LX2761 | 分子名称: | N-[2-(dimethylamino)ethyl]-2-methyl-2-[4-[4-[[2-methyl-5-[(2S,3R,4R,5S,6R)-6-methylsulfanyl-3,4,5-tris(oxidanyl)oxan-2-yl]phenyl]methyl]phenyl]butanoylamino]propanamide, PDZK1-interacting protein 1, Sodium/glucose cotransporter 1 | 著者 | Chen, L, Niu, Y, Cui, W. | 登録日 | 2022-01-17 | 公開日 | 2022-11-16 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural mechanism of SGLT1 inhibitors. Nat Commun, 13, 2022
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7WIT
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![BU of 7wit by Molmil](/molmil-images/mine/7wit) | Structure of SUR1 in complex with mitiglinide | 分子名称: | (2S)-4-[(3aR,7aS)-1,3,3a,4,5,6,7,7a-octahydroisoindol-2-yl]-4-oxidanylidene-2-(phenylmethyl)butanoic acid, ADENOSINE-5'-TRIPHOSPHATE, ATP-sensitive inward rectifier potassium channel 11,ATP-binding cassette sub-family C member 8 isoform X1 | 著者 | Chen, L, Wang, M.M. | 登録日 | 2022-01-04 | 公開日 | 2022-11-16 | 最終更新日 | 2022-12-21 | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | 主引用文献 | Structural Insights Into the High Selectivity of the Anti-Diabetic Drug Mitiglinide Front Pharmacol, 13, 2022
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7Y1K
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![BU of 7y1k by Molmil](/molmil-images/mine/7y1k) | Structure of SUR2A in complex with Mg-ATP, Mg-ADP and repaglinide in the inward-facing conformation | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 9, ... | 著者 | Chen, L, Ding, D, Hou, T. | 登録日 | 2022-06-08 | 公開日 | 2023-06-14 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | The inhibition mechanism of the SUR2A-containing K ATP channel by a regulatory helix. Nat Commun, 14, 2023
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7Y1J
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![BU of 7y1j by Molmil](/molmil-images/mine/7y1j) | Structure of SUR2A in complex with Mg-ATP and repaglinide in the inward-facing conformation. | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 9, MAGNESIUM ION, ... | 著者 | Chen, L, Ding, D, Hou, T. | 登録日 | 2022-06-08 | 公開日 | 2023-06-14 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | The inhibition mechanism of the SUR2A-containing K ATP channel by a regulatory helix. Nat Commun, 14, 2023
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7Y1L
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![BU of 7y1l by Molmil](/molmil-images/mine/7y1l) | Structure of SUR2B in complex with Mg-ATP and repaglinide in the inward-facing conformation | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Isoform SUR2B of ATP-binding cassette sub-family C member 9, MAGNESIUM ION, ... | 著者 | Chen, L, Ding, D, Hou, T. | 登録日 | 2022-06-08 | 公開日 | 2023-06-14 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (3.73 Å) | 主引用文献 | The inhibition mechanism of the SUR2A-containing K ATP channel by a regulatory helix. Nat Commun, 14, 2023
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7Y1M
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![BU of 7y1m by Molmil](/molmil-images/mine/7y1m) | Structure of SUR2B in complex with Mg-ATP, Mg-ADP, and repaglinide in the inward-facing conformation | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Isoform SUR2B of ATP-binding cassette sub-family C member 9, ... | 著者 | Chen, L, Ding, D, Hou, T. | 登録日 | 2022-06-08 | 公開日 | 2023-06-14 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (3.57 Å) | 主引用文献 | The inhibition mechanism of the SUR2A-containing K ATP channel by a regulatory helix. Nat Commun, 14, 2023
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7Y1N
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![BU of 7y1n by Molmil](/molmil-images/mine/7y1n) | Structure of SUR2B in complex with Mg-ATP, Mg-ADP, and repaglinide in the partially occluded state | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Isoform SUR2B of ATP-binding cassette sub-family C member 9, ... | 著者 | Chen, L, Ding, D, Hou, T. | 登録日 | 2022-06-08 | 公開日 | 2023-06-14 | 最終更新日 | 2023-10-11 | 実験手法 | ELECTRON MICROSCOPY (3.61 Å) | 主引用文献 | The inhibition mechanism of the SUR2A-containing K ATP channel by a regulatory helix. Nat Commun, 14, 2023
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