8HBH
 
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8HBW
 | | Structure of human UCP1 in the ATP-bound state | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-5'-TRIPHOSPHATE, CARDIOLIPIN, ... | | 著者 | Chen, L, Kang, Y. | | 登録日 | 2022-10-31 | | 公開日 | 2023-06-21 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (2.57 Å) | | 主引用文献 | Structural basis for the binding of DNP and purine nucleotides onto UCP1.
Nature, 620, 2023
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8HBV
 | | Structure of human UCP1 in the nucleotide-free state | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CARDIOLIPIN, Mitochondrial brown fat uncoupling protein 1, ... | | 著者 | Chen, L, Kang, Y. | | 登録日 | 2022-10-31 | | 公開日 | 2023-06-21 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (2.51 Å) | | 主引用文献 | Structural basis for the binding of DNP and purine nucleotides onto UCP1.
Nature, 620, 2023
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5ZBG
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5YX9
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8J1N
 | | Structure of human UCP1 in the DNP-bound state | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2,4-DINITROPHENOL, CARDIOLIPIN, ... | | 著者 | Chen, L, Kang, Y. | | 登録日 | 2023-04-13 | | 公開日 | 2023-06-21 | | 最終更新日 | 2023-08-30 | | 実験手法 | ELECTRON MICROSCOPY (2.51 Å) | | 主引用文献 | Structural basis for the binding of DNP and purine nucleotides onto UCP1.
Nature, 620, 2023
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7W7G
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7W4P
 | | The structure of KATP H175K mutant in closed state | | 分子名称: | 6-chloranyl-~{N}-(1-methylcyclopropyl)-1,1-bis(oxidanylidene)-4~{H}-thieno[3,2-e][1,2,4]thiadiazin-3-amine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Chen, L, Wang, M. | | 登録日 | 2021-11-28 | | 公開日 | 2022-06-01 | | 最終更新日 | 2024-10-30 | | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | | 主引用文献 | Structural insights into the mechanism of pancreatic K ATP channel regulation by nucleotides.
Nat Commun, 13, 2022
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7W4O
 | | The structure of KATP H175K mutant in pre-open state | | 分子名称: | 6-chloranyl-~{N}-(1-methylcyclopropyl)-1,1-bis(oxidanylidene)-4~{H}-thieno[3,2-e][1,2,4]thiadiazin-3-amine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Chen, L, Wang, M. | | 登録日 | 2021-11-28 | | 公開日 | 2022-06-01 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | | 主引用文献 | Structural insights into the mechanism of pancreatic K ATP channel regulation by nucleotides.
Nat Commun, 13, 2022
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7WIT
 | | Structure of SUR1 in complex with mitiglinide | | 分子名称: | (2S)-4-[(3aR,7aS)-1,3,3a,4,5,6,7,7a-octahydroisoindol-2-yl]-4-oxidanylidene-2-(phenylmethyl)butanoic acid, ADENOSINE-5'-TRIPHOSPHATE, ATP-sensitive inward rectifier potassium channel 11,ATP-binding cassette sub-family C member 8 isoform X1 | | 著者 | Chen, L, Wang, M.M. | | 登録日 | 2022-01-04 | | 公開日 | 2022-11-16 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | | 主引用文献 | Structural Insights Into the High Selectivity of the Anti-Diabetic Drug Mitiglinide
Front Pharmacol, 13, 2022
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7WMV
 | | Structure of human SGLT1-MAP17 complex bound with LX2761 | | 分子名称: | N-[2-(dimethylamino)ethyl]-2-methyl-2-[4-[4-[[2-methyl-5-[(2S,3R,4R,5S,6R)-6-methylsulfanyl-3,4,5-tris(oxidanyl)oxan-2-yl]phenyl]methyl]phenyl]butanoylamino]propanamide, PDZK1-interacting protein 1, Sodium/glucose cotransporter 1 | | 著者 | Chen, L, Niu, Y, Cui, W. | | 登録日 | 2022-01-17 | | 公開日 | 2022-11-16 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural mechanism of SGLT1 inhibitors.
Nat Commun, 13, 2022
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7WDB
 | | Human TRPC5 channel in complex with riluzole | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine, CALCIUM ION, ... | | 著者 | Chen, L, Wei, M, Yang, Y. | | 登録日 | 2021-12-21 | | 公開日 | 2022-04-13 | | 最終更新日 | 2022-08-03 | | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | | 主引用文献 | Structural identification of riluzole-binding site on human TRPC5.
Cell Discov, 8, 2022
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6JB1
 | | Structure of pancreatic ATP-sensitive potassium channel bound with repaglinide and ATPgammaS at 3.3A resolution | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ... | | 著者 | Chen, L, Ding, D, Wang, M, Wu, J.-X, Kang, Y. | | 登録日 | 2019-01-25 | | 公開日 | 2019-05-22 | | 最終更新日 | 2021-09-29 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | The Structural Basis for the Binding of Repaglinide to the Pancreatic KATPChannel.
Cell Rep, 27, 2019
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5YKF
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5YKG
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6JPF
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5YKE
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6JT2
 | | Structure of human soluble guanylate cyclase in the NO activated state | | 分子名称: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, MAGNESIUM ION, ... | | 著者 | Chen, L, Kang, Y, Liu, R, Wu, J.-X. | | 登録日 | 2019-04-08 | | 公開日 | 2019-09-04 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structural insights into the mechanism of human soluble guanylate cyclase.
Nature, 574, 2019
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5YW9
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5YWB
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5YWC
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5YW8
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5Z1F
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5YWD
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5YW7
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