7YNI

Structure of human SGLT1-MAP17 complex bound with substrate 4D4FDG in the occluded conformation

Summary for 7YNI

• Entry DOI: 10.2210/pdb7yni/pdb
• EMDB information: 33962
• Descriptor: Sodium/glucose cotransporter 1, PDZK1-interacting protein 1, (2R,3R,4R,5S,6R)-5-fluoranyl-6-(hydroxymethyl)oxane-2,3,4-triol (3 entities in total)
• Functional Keywords: glucose transporter, sglt, sodium glucose transporter, membrane protein, protein transport
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 85974.85

Authors

Chen, L.,Niu, Y.,Cui, W. (deposition date: 2022-07-31, release date: 2023-05-31, Last modification date: 2023-12-13)

• Primary citation: Cui, W.,Niu, Y.,Sun, Z.,Liu, R.,Chen, L.; Structures of human SGLT in the occluded state reveal conformational changes during sugar transport.; Nat Commun, 14:2920-2920, 2023; PubMed: 37217492; DOI: 10.1038/s41467-023-38720-1

Experimental method

ELECTRON MICROSCOPY (3.26 Å)