7N4V
 
 | | Structure of cholesterol-bound human NPC1L1 | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Li, X, Long, T. | | 登録日 | 2021-06-04 | | 公開日 | 2021-09-01 | | 最終更新日 | 2022-03-16 | | 実験手法 | ELECTRON MICROSCOPY (3.58 Å) | | 主引用文献 | Structures of dimeric human NPC1L1 provide insight into mechanisms for cholesterol absorption.
Sci Adv, 7, 2021
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6C9U
 | | Crystal structure of [KS3][AT3] didomain from module 3 of 6-deoxyerthronolide B synthase in complex with antibody fragment (Fab) | | 分子名称: | 6-deoxyerythronolide-B synthase EryA2, modules 3 and 4, Heavy chain of Fab 1B2, ... | | 著者 | Deis, L.N, Li, X, Mathews, I.I, Khosla, C. | | 登録日 | 2018-01-28 | | 公開日 | 2018-05-23 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | Structure-Function Analysis of the Extended Conformation of a Polyketide Synthase Module.
J. Am. Chem. Soc., 140, 2018
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3UR1
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8XJK
 | | Cloprosetnol bound Prostaglandin F2-alpha receptor-Gq Protein Complex | | 分子名称: | (~{Z})-7-[(1~{R},2~{R},3~{R},5~{S})-2-[(~{E},3~{R})-4-(3-chloranylphenoxy)-3-oxidanyl-but-1-enyl]-3,5-bis(oxidanyl)cyclopentyl]hept-5-enoic acid, Antibody fragment scFv16, Engineered miniGq, ... | | 著者 | Zhang, X, Li, X, Liu, G, Gong, W. | | 登録日 | 2023-12-21 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (2.63 Å) | | 主引用文献 | Structural basis for ligand recognition and activation of the prostanoid receptors.
Cell Rep, 43, 2024
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8XJO
 | | U46619 bound Thromboxane A2 receptor-Gq Protein Complex | | 分子名称: | (5Z)-7-{(1R,4S,5S,6R)-6-[(1E,3S)-3-hydroxyoct-1-en-1-yl]-2-oxabicyclo[2.2.1]hept-5-yl}hept-5-enoic acid, Antibody fragment scFv16, Engineered miniGq, ... | | 著者 | Zhang, X, Li, X, Liu, G, Gong, W. | | 登録日 | 2023-12-21 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | | 主引用文献 | Structural basis for ligand recognition and activation of the prostanoid receptors.
Cell Rep, 43, 2024
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8XJN
 | | Cloprosetnol bound Thromboxane A2 receptor-Gq Protein Complex | | 分子名称: | (~{Z})-7-[(1~{R},2~{R},3~{R},5~{S})-2-[(~{E},3~{R})-4-(3-chloranylphenoxy)-3-oxidanyl-but-1-enyl]-3,5-bis(oxidanyl)cyclopentyl]hept-5-enoic acid, Antibody fragment scFv16, Engineered miniGq, ... | | 著者 | Zhang, X, Li, X, Liu, G, Gong, W. | | 登録日 | 2023-12-21 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | | 主引用文献 | Structural basis for ligand recognition and activation of the prostanoid receptors.
Cell Rep, 43, 2024
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8XJL
 | | PGF2-alpha bound Prostaglandin F2-alpha receptor-Gq Protein Complex | | 分子名称: | (Z)-7-[(1R,2R,3R,5S)-3,5-bis(oxidanyl)-2-[(E,3S)-3-oxidanyloct-1-enyl]cyclopentyl]hept-5-enoic acid, Antibody fragment scFv16, Engineered miniGq, ... | | 著者 | Zhang, X, Li, X, Liu, G, Gong, W. | | 登録日 | 2023-12-21 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (2.77 Å) | | 主引用文献 | Structural basis for ligand recognition and activation of the prostanoid receptors.
Cell Rep, 43, 2024
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8XJM
 | | Latanoprost acid bound Prostaglandin F2-alpha receptor-Gq Protein Complex | | 分子名称: | Antibody fragment scFv16, Engineered miniGq, Fusion tag,Prostaglandin F2-alpha receptor,LgBiT, ... | | 著者 | Zhang, X, Li, X, Liu, G, Gong, W. | | 登録日 | 2023-12-21 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | | 主引用文献 | Structural basis for ligand recognition and activation of the prostanoid receptors.
Cell Rep, 43, 2024
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7EQH
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8J45
 | | Crystal structure of a Pichia pastoris-expressed IsPETase variant | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Poly(ethylene terephthalate) hydrolase | | 著者 | Li, X, He, H.L, Long, X, Niu, D, Huang, J.-W, Chen, C.-C, Guo, R.-T. | | 登録日 | 2023-04-19 | | 公開日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | | 主引用文献 | Complete decomposition of poly(ethylene terephthalate) by crude PET hydrolytic enzyme produced in Pichia pastoris
Chem Eng J, 2023
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8W51
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8KIE
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6MLK
 | | Structure of Thioesterase from DEBS with a thioesterase-specific antibody | | 分子名称: | 6-deoxyerythronolide-B synthase EryA3, modules 5 and 6, CHLORIDE ION, ... | | 著者 | Mathews, I.I, Li, X, Khosla, C. | | 登録日 | 2018-09-27 | | 公開日 | 2018-10-17 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | | 主引用文献 | Discovery and Characterization of a Thioesterase-Specific Monoclonal Antibody That Recognizes the 6-Deoxyerythronolide B Synthase.
Biochemistry, 57, 2018
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6N7R
 | | Saccharomyces cerevisiae spliceosomal E complex (ACT1) | | 分子名称: | 56 kDa U1 small nuclear ribonucleoprotein component, ACT1 pre-mRNA, Pre-mRNA-processing factor 39, ... | | 著者 | Liu, S, Li, X, Zhou, Z.H, Zhao, R. | | 登録日 | 2018-11-28 | | 公開日 | 2019-09-18 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | A unified mechanism for intron and exon definition and back-splicing.
Nature, 573, 2019
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7Y9I
 | | Complex structure of AtYchF1 with ppGpp | | 分子名称: | GUANOSINE-5',3'-TETRAPHOSPHATE, MAGNESIUM ION, Obg-like ATPase 1 | | 著者 | Li, X, Chen, Z. | | 登録日 | 2022-06-24 | | 公開日 | 2023-07-12 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | | 主引用文献 | Co-crystalization reveals the interaction between AtYchF1 and ppGpp.
Front Mol Biosci, 9, 2022
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6N7P
 | | S. cerevisiae spliceosomal E complex (UBC4) | | 分子名称: | 56 kDa U1 small nuclear ribonucleoprotein component, Nuclear cap-binding protein complex subunit 1, Nuclear cap-binding protein subunit 2, ... | | 著者 | Liu, S, Li, X, Zhou, Z.H, Zhao, R. | | 登録日 | 2018-11-27 | | 公開日 | 2019-09-18 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | | 主引用文献 | A unified mechanism for intron and exon definition and back-splicing.
Nature, 573, 2019
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8Z0L
 | | Cryo-EM structure of Cas8-HNH system at partial R-loop state | | 分子名称: | DNA (32-MER), DNA (5'-D(P*GP*TP*GP*CP*GP*GP*A)-3'), HNH endonuclease, ... | | 著者 | Zhang, H, Zhu, H, Li, X, Liu, Y. | | 登録日 | 2024-04-09 | | 公開日 | 2024-10-02 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (2.57 Å) | | 主引用文献 | Structural basis for the type I-F Cas8-HNH system.
Embo J., 2024
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8ZDY
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8Z0K
 | | Cryo-EM structure of Cas8-HNH system at full R-loop state | | 分子名称: | DNA (37-MER), DNA (5'-D(P*GP*TP*GP*CP*GP*GP*A)-3'), HNH endonuclease, ... | | 著者 | Zhang, H, Zhu, H, Li, X, Liu, Y. | | 登録日 | 2024-04-09 | | 公開日 | 2024-10-02 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (2.51 Å) | | 主引用文献 | Structural basis for the type I-F Cas8-HNH system.
Embo J., 2024
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8ZNR
 | | Cryo-EM structure of Cas8-HNH system at ssDNA-bound state | | 分子名称: | DNA (35-MER), RNA (56-MER), protein structure | | 著者 | Zhang, H, Zhu, H, Li, X, Liu, Y. | | 登録日 | 2024-05-28 | | 公開日 | 2024-10-02 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural basis for the type I-F Cas8-HNH system.
Embo J., 2024
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7YPG
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7W7F
 | | Cryo-EM structure of human NaV1.3/beta1/beta2-ICA121431 | | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2,2-diphenyl-~{N}-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]ethanamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Jiang, D, Li, X. | | 登録日 | 2021-12-04 | | 公開日 | 2022-04-06 | | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | | 主引用文献 | Structural basis for modulation of human Na V 1.3 by clinical drug and selective antagonist.
Nat Commun, 13, 2022
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7W77
 | | cryo-EM structure of human NaV1.3/beta1/beta2-bulleyaconitineA | | 分子名称: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Jiang, D, Li, X. | | 登録日 | 2021-12-03 | | 公開日 | 2022-04-06 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural basis for modulation of human Na V 1.3 by clinical drug and selective antagonist.
Nat Commun, 13, 2022
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4CDQ
 | | Crystal structure of human Enterovirus 71 in complex with the uncoating inhibitor GPP2 | | 分子名称: | 4-((5-(2-oxo-3-(pyridin-4-yl)imidazolidin-1-yl)pentyl)oxy)benzaldehyde O-ethyl oxime, SODIUM ION, VP1, ... | | 著者 | DeColibus, L, Wang, X, Spyrou, J.A.B, Kelly, J, Ren, J, Grimes, J, Puerstinger, G, Stonehouse, N, Walter, T.S, Hu, Z, Wang, J, Li, X, Peng, W, Rowlands, D, Fry, E.E, Rao, Z, Stuart, D.I. | | 登録日 | 2013-11-05 | | 公開日 | 2014-02-12 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | More-Powerful Virus Inhibitors from Structure-Based Analysis of Hev71 Capsid-Binding Molecules
Nat.Struct.Mol.Biol., 21, 2014
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4CEW
 | | Crystal structure of human Enterovirus 71 in complex with the uncoating inhibitor ALD | | 分子名称: | 4-[3-[(3s)-5-[4-[(e)-ethoxyiminomethyl]phenoxy]-3-methyl-pentyl]-2-oxidanylidene-imidazolidin-1-yl]pyridine-2-carboxamide, VP1, VP2, ... | | 著者 | De Colibus, L, Wang, X, Spyrou, J.A.B, Kelly, J, Ren, J, Grimes, J, Puerstinger, G, Stonehouse, N, Walter, T.S, Hu, Z, Wang, J, Li, X, Peng, W, Rowlands, D, Fry, E.E, Rao, Z, Stuart, D.I. | | 登録日 | 2013-11-12 | | 公開日 | 2014-02-12 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | More-Powerful Virus Inhibitors from Structure-Based Analysis of Hev71 Capsid-Binding Molecules.
Nat.Struct.Mol.Biol., 21, 2014
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