3NDM
Crystal structure of Rho-Associated Protein Kinase (ROCK1) with a potent isoquinolone derivative
Summary for 3NDM
Entry DOI | 10.2210/pdb3ndm/pdb |
Related | 3NCZ |
Descriptor | Rho-Associated Protein Kinase (ROCK1), (3S,4R)-N-(7-chloro-1-oxo-1,4-dihydroisoquinolin-6-yl)-4-(4-chlorophenyl)pyrrolidine-3-carboxamide (3 entities in total) |
Functional Keywords | rho kinase, phosphorylation, dimerization, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: Q13464 |
Total number of polymer chains | 4 |
Total formula weight | 193255.96 |
Authors | |
Primary citation | Bosanac, T.,Hickey, E.R.,Ginn, J.,Kashem, M.,Kerr, S.,Kugler, S.,Li, X.,Olague, A.,Schlyer, S.,Young, E.R. Substituted 2H-isoquinolin-1-ones as potent Rho-kinase inhibitors: part 3, aryl substituted pyrrolidines. Bioorg.Med.Chem.Lett., 20:3746-3749, 2010 Cited by PubMed: 20471253DOI: 10.1016/j.bmcl.2010.04.069 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.3 Å) |
Structure validation
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