4YMQ

X-ray co-structure of nuclear receptor ROR-GAMMAT + SRC2 peptide with a benzothiadiazole dioxide inverse agonist

Summary for 4YMQ

Entry DOI	10.2210/pdb4ymq/pdb
Descriptor	Nuclear receptor ROR-gamma, SODIUM ION, GLYCEROL, ... (5 entities in total)
Functional Keywords	rorgt, nuclear hormone receptor, benzothiadiazole dioxide, inverse agonist
Biological source	Homo sapiens (Human)
Cellular location	Nucleus : P51449
Total number of polymer chains	1
Total formula weight	33155.09
Authors	li, X. (deposition date: 2015-03-07, release date: 2015-04-22, Last modification date: 2024-02-28)
Primary citation	Muegge, I.,Collin, D.,Cook, B.,Hill-Drzewi, M.,Horan, J.,Kugler, S.,Labadia, M.,Li, X.,Smith, L.,Zhang, Y. Discovery of 1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide analogs as new RORC modulators. Bioorg.Med.Chem.Lett., 25:1892-1895, 2015 Cited by PubMed: 25840886 DOI: 10.1016/j.bmcl.2015.03.042 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation