4YMQ

X-ray co-structure of nuclear receptor ROR-GAMMAT + SRC2 peptide with a benzothiadiazole dioxide inverse agonist

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003677	molecular_function	DNA binding
A	0004879	molecular_function	nuclear receptor activity
A	0005634	cellular_component	nucleus
A	0006355	biological_process	regulation of DNA-templated transcription

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue NA A 601

Chain	Residue
A	CYS366
A	TYR369
A	SER408
A	HOH775
A	HOH776
A	HOH791

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site_id	AC2
Number of Residues	7
Details	binding site for residue GOL A 602

Chain	Residue
A	GLN495
A	ALA496
A	PHE498
A	LYS503
A	HIS452
A	CYS455
A	LYS456

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site_id	AC3
Number of Residues	22
Details	binding site for residue ZBD A 603

Chain	Residue
A	GLN286
A	CYS320
A	LEU324
A	MET358
A	VAL361
A	ARG364
A	MET365
A	ARG367
A	ALA368
A	VAL376
A	PHE377
A	PHE378
A	PHE388
A	LEU391
A	LEU396
A	ILE397
A	ILE400
A	PHE401
A	SER404
A	HIS479
A	HOH757
A	HOH790

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