5MK3
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6D1R
| Structure of Staphylococcus aureus RNase P protein at 2.0 angstrom | 分子名称: | Ribonuclease P protein component | 著者 | Ha, L, Colquhoun, J, Noinaj, N, Das, C, Dunman, P, Flaherty, D.P. | 登録日 | 2018-04-12 | 公開日 | 2018-09-26 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.995 Å) | 主引用文献 | Crystal structure of the ribonuclease-P-protein subunit from Staphylococcus aureus. Acta Crystallogr F Struct Biol Commun, 74, 2018
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6CZK
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8PTU
| 2.5 A cryo-EM structure of the in vitro FimD-catalyzed assembly of type 1 pilus rod | 分子名称: | Type-1 fimbrial protein, A chain | 著者 | Zyla, D, Hospenthal, M, Glockshuber, R, Waksman, G. | 登録日 | 2023-07-14 | 公開日 | 2024-04-10 | 最終更新日 | 2024-04-17 | 実験手法 | ELECTRON MICROSCOPY (2.52 Å) | 主引用文献 | The assembly platform FimD is required to obtain the most stable quaternary structure of type 1 pili. Nat Commun, 15, 2024
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5O6A
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6EEZ
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5FX3
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7DVA
| Structure of wild type Bt4394, a GH20 family sulfoglycosidase, in complex with 6S-GlcNAc | 分子名称: | 2-acetamido-2-deoxy-6-O-sulfo-beta-D-glucopyranose, Beta-N-acetylhexosaminidase, GLYCEROL | 著者 | Zhang, Z, He, Y, Jin, Y. | 登録日 | 2021-01-13 | 公開日 | 2022-01-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Mechanistic and Structural Insights into the Specificity and Biological Functions of Bacterial Sulfoglycosidases Acs Catalysis, 13, 2023
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7DUP
| Apo structure of wild type Bt4394, a GH20 family sulfoglycosidase | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Beta-N-acetylhexosaminidase, CHLORIDE ION, ... | 著者 | Zhang, Z, He, Y, Jin, Y. | 登録日 | 2021-01-10 | 公開日 | 2022-01-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.62 Å) | 主引用文献 | Mechanistic and Structural Insights into the Specificity and Biological Functions of Bacterial Sulfoglycosidases Acs Catalysis, 13, 2023
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7DVB
| D335N variant of Bt4394 in complex with 6SO3-NAG-oxazoline intermediate | 分子名称: | 2-acetamido-2-deoxy-6-O-sulfo-beta-D-glucopyranose, Beta-N-acetylhexosaminidase, [(3~{a}~{R},5~{R},6~{S},7~{R},7~{a}~{R})-2-methyl-6,7-bis(oxidanyl)-5,6,7,7~{a}-tetrahydro-3~{a}~{H}-pyrano[3,2-d][1,3]oxazol-1-ium-5-yl]methyl sulfate | 著者 | Zhang, Z, He, Y, Jin, Y. | 登録日 | 2021-01-13 | 公開日 | 2022-01-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Mechanistic and Structural Insights into the Specificity and Biological Functions of Bacterial Sulfoglycosidases Acs Catalysis, 13, 2023
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5FS5
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5FWR
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5TOZ
| JAK3 with covalent inhibitor PF-06651600 | 分子名称: | 1-{(2S,5R)-2-methyl-5-[(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}propan-1-one, SULFATE ION, Tyrosine-protein kinase JAK3 | 著者 | Vajdos, F.F. | 登録日 | 2016-10-19 | 公開日 | 2016-11-09 | 最終更新日 | 2017-11-22 | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | 主引用文献 | Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition. ACS Chem. Biol., 11, 2016
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4B4P
| Crystal Structure of the lectin domain of F18 fimbrial adhesin FedF. | 分子名称: | BROMIDE ION, F18 FIMBRIAL ADHESIN AC, SULFATE ION | 著者 | Moonens, K, Bouckaert, J, Coddens, A, Tran, T, Panjikar, S, De Kerpel, M, Cox, E, Remaut, H, De Greve, H. | 登録日 | 2012-07-31 | 公開日 | 2012-08-15 | 最終更新日 | 2019-10-16 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural Insight in Histo-Blood Group Binding by the F18 Fimbrial Adhesin Fedf. Mol.Microbiol., 86, 2012
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4B4R
| Crystal Structure of the lectin domain of F18 fimbrial adhesin FedF in complex with blood group B type 1 hexasaccharide | 分子名称: | F18 FIMBRIAL ADHESIN AC, alpha-L-fucopyranose-(1-2)-[alpha-D-galactopyranose-(1-3)]beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose | 著者 | Moonens, K, Bouckaert, J, Coddens, A, Tran, T, Panjikar, S, De Kerpel, M, Cox, E, Remaut, H, De Greve, H. | 登録日 | 2012-07-31 | 公開日 | 2012-08-15 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural Insight in Histo-Blood Group Binding by the F18 Fimbrial Adhesin Fedf. Mol.Microbiol., 86, 2012
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4B4Q
| Crystal Structure of the lectin domain of F18 fimbrial adhesin FedF in complex with blood group A type 1 hexasaccharide | 分子名称: | F18 FIMBRIAL ADHESIN AC, alpha-L-fucopyranose-(1-2)-[2-acetamido-2-deoxy-alpha-D-galactopyranose-(1-3)]beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose | 著者 | Moonens, K, Bouckaert, J, Coddens, A, Tran, T, Panjikar, S, De Kerpel, M, Cox, E, Remaut, H, De Greve, H. | 登録日 | 2012-07-31 | 公開日 | 2012-08-15 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural Insight in Histo-Blood Group Binding by the F18 Fimbrial Adhesin Fedf. Mol.Microbiol., 86, 2012
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8Q1K
| Structural analysis of PLD3 reveals insights into the mechanism of lysosomal 5' exonuclease-mediated nucleic acid degradation | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5'-3' exonuclease PLD3, ... | 著者 | Roske, Y, Daumke, O, Damme, M. | 登録日 | 2023-07-31 | 公開日 | 2023-12-06 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | 主引用文献 | Structural analysis of PLD3 reveals insights into the mechanism of lysosomal 5' exonuclease-mediated nucleic acid degradation. Nucleic Acids Res., 52, 2024
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8Q1X
| Structural analysis of PLD3 reveals insights into the mechanism of lysosomal 5' exonuclease-mediated nucleic acid degradation | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5'-3' exonuclease PLD3, ... | 著者 | Roske, Y, Daumke, O, Damme, M. | 登録日 | 2023-08-01 | 公開日 | 2023-12-06 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structural analysis of PLD3 reveals insights into the mechanism of lysosomal 5' exonuclease-mediated nucleic acid degradation. Nucleic Acids Res., 52, 2024
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6AN6
| Crystal structure of Escherichia coli HPPK in complex with bisubstrate analogue inhibitor HP-72 | 分子名称: | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 5'-S-{2-[{2-[(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridine-6-carbonyl)amino]ethyl}(phosphonomethyl)amino]ethyl}-5'-thioadenosine | 著者 | Shaw, G.X, Shi, G, Ji, X. | 登録日 | 2017-08-12 | 公開日 | 2018-08-15 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Bisubstrate analogue inhibitors of HPPK: Transition state mimetics to be published
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6AN4
| Crystal structure of Escherichia coli HPPK in complex with bisubstrate analogue inhibitor HP-39 (J1F) | 分子名称: | ((2-(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridine-6-carboxamido)-N-(2-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)amino)-2-oxoethyl)acetamido)methyl)phosphonic acid, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, CHLORIDE ION | 著者 | Shaw, G.X, Shi, G, Ji, X. | 登録日 | 2017-08-12 | 公開日 | 2018-08-15 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Bisubstrate analog inhibitors of HPPK: Transition state mimetics to be published
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4CA4
| Crystal structure of FimH lectin domain with the Tyr48Ala mutation, in complex with heptyl alpha-D-mannopyrannoside | 分子名称: | FIMH, heptyl alpha-D-mannopyranoside | 著者 | Rabbani, S, Bouckaert, J, Zalewski, A, Preston, R, Eid, S, Thompson, A, Puorger, C, Glockshuber, R, Ernst, B. | 登録日 | 2013-10-06 | 公開日 | 2014-10-29 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.84 Å) | 主引用文献 | Mutation of Tyr137 of the universal Escherichia coli fimbrial adhesin FimH relaxes the tyrosine gate prior to mannose binding. IUCrJ, 4, 2017
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4BYJ
| Aurora A kinase bound to a highly selective imidazopyridine inhibitor | 分子名称: | (S)-N-(1-(6-chloro-2-(1,3-dimethyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-3-yl)acetamide, AURORA KINASE A | 著者 | Joshi, A, Kosmopoulou, M, Bayliss, R. | 登録日 | 2013-07-19 | 公開日 | 2013-11-20 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Aurora Isoform Selectivity: Design and Synthesis of Imidazo[4,5-B]Pyridine Derivatives as Highly Selective Inhibitors of Aurora-A Kinase in Cells. J.Med.Chem., 56, 2013
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4BYI
| Aurora A kinase bound to a highly selective imidazopyridine inhibitor | 分子名称: | (S)-N-((1-(6-chloro-2-(1,3-dimethyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl)pyrrolidin-3-yl)methyl)acetamide, AURORA KINASE A | 著者 | Joshi, A, Kosmopoulou, M, Bayliss, R. | 登録日 | 2013-07-19 | 公開日 | 2013-11-20 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Aurora Isoform Selectivity: Design and Synthesis of Imidazo[4,5-B]Pyridine Derivatives as Highly Selective Inhibitors of Aurora-A Kinase in Cells. J.Med.Chem., 56, 2013
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5NSP
| Crystal structure of TNKS2 in complex with OD334 | 分子名称: | 1-[4-[4-(2-chlorophenyl)-5-pyrimidin-4-yl-1,2,4-triazol-3-yl]phenyl]-2-oxidanylidene-3~{H}-benzimidazole-5-carbonitrile, BICARBONATE ION, GLYCEROL, ... | 著者 | Nkizinkiko, Y, Haikarainen, T, Lehtio, L. | 登録日 | 2017-04-26 | 公開日 | 2017-11-29 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach. J. Med. Chem., 60, 2017
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5ORF
| Structure of ovine serum albumin in P1 space group | 分子名称: | DI(HYDROXYETHYL)ETHER, PROLINE, Serum albumin, ... | 著者 | Talaj, J.A, Bujacz, A, Bujacz, G, Pietrzyk-Brzezinska, A.J. | 登録日 | 2017-08-16 | 公開日 | 2017-11-15 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | 主引用文献 | Crystal structures of serum albumins from domesticated ruminants and their complexes with 3,5-diiodosalicylic acid. Acta Crystallogr D Struct Biol, 73, 2017
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