5FX3

Breaking down the wall: mutation of the tyrosine gate of the universal Escherichia coli fimbrial adhesin FimH

Summary for 5FX3

Entry DOI	10.2210/pdb5fx3/pdb
Related	5FWR
Descriptor	FimH, {[-(BIS-CARBOXYMETHYL-AMINO)-ETHYL]-CARBOXYMETHYL-AMINO}-ACETIC ACID (3 entities in total)
Functional Keywords	cell adhesion, bacterial adhesin, type 1 fimbriae, urinary tract infection, variable immunoglobulin fold
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	17158.00
Authors	Bouckaert, J. (deposition date: 2016-02-22, release date: 2017-01-18, Last modification date: 2024-01-10)
Primary citation	Rabbani, S.,Krammer, E.M.,Roos, G.,Zalewski, A.,Preston, R.,Eid, S.,Zihlmann, P.,Prevost, M.,Lensink, M.F.,Thompson, A.,Ernst, B.,Bouckaert, J. Mutation of Tyr137 of the universal Escherichia coli fimbrial adhesin FimH relaxes the tyrosine gate prior to mannose binding. IUCrJ, 4:7-23, 2017 Cited by PubMed: 28250938 DOI: 10.1107/S2052252516016675 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation