6AN4
Crystal structure of Escherichia coli HPPK in complex with bisubstrate analogue inhibitor HP-39 (J1F)
Summary for 6AN4
Entry DOI | 10.2210/pdb6an4/pdb |
Descriptor | 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, ((2-(2-amino-7,7-dimethyl-4-oxo-3,4,7,8-tetrahydropteridine-6-carboxamido)-N-(2-((((2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl)amino)-2-oxoethyl)acetamido)methyl)phosphonic acid, CHLORIDE ION, ... (4 entities in total) |
Functional Keywords | alpha beta, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Escherichia coli (strain K12) |
Total number of polymer chains | 1 |
Total formula weight | 18695.55 |
Authors | Shaw, G.X.,Shi, G.,Ji, X. (deposition date: 2017-08-12, release date: 2018-08-15, Last modification date: 2023-08-30) |
Primary citation | Shaw, X.G.,Shi, G.,Ji, X. Bisubstrate analog inhibitors of HPPK: Transition state mimetics to be published, |
Experimental method | X-RAY DIFFRACTION (1.47 Å) |
Structure validation
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