5TOZ
JAK3 with covalent inhibitor PF-06651600
Summary for 5TOZ
Entry DOI | 10.2210/pdb5toz/pdb |
Descriptor | Tyrosine-protein kinase JAK3, 1-{(2S,5R)-2-methyl-5-[(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl}propan-1-one, SULFATE ION, ... (4 entities in total) |
Functional Keywords | jak3 covalent kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Endomembrane system ; Peripheral membrane protein : P52333 |
Total number of polymer chains | 1 |
Total formula weight | 36927.08 |
Authors | Vajdos, F.F. (deposition date: 2016-10-19, release date: 2016-11-09, Last modification date: 2017-11-22) |
Primary citation | Telliez, J.B.,Dowty, M.E.,Wang, L.,Jussif, J.,Lin, T.,Li, L.,Moy, E.,Balbo, P.,Li, W.,Zhao, Y.,Crouse, K.,Dickinson, C.,Symanowicz, P.,Hegen, M.,Banker, M.E.,Vincent, F.,Unwalla, R.,Liang, S.,Gilbert, A.M.,Brown, M.F.,Hayward, M.,Montgomery, J.,Yang, X.,Bauman, J.,Trujillo, J.I.,Casimiro-Garcia, A.,Vajdos, F.F.,Leung, L.,Geoghegan, K.F.,Quazi, A.,Xuan, D.,Jones, L.,Hett, E.,Wright, K.,Clark, J.D.,Thorarensen, A. Discovery of a JAK3-Selective Inhibitor: Functional Differentiation of JAK3-Selective Inhibition over pan-JAK or JAK1-Selective Inhibition. ACS Chem. Biol., 11:3442-3451, 2016 Cited by PubMed: 27791347DOI: 10.1021/acschembio.6b00677 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.98 Å) |
Structure validation
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