5NSP

Crystal structure of TNKS2 in complex with OD334

Summary for 5NSP

Entry DOI	10.2210/pdb5nsp/pdb
Descriptor	Tankyrase-2, ZINC ION, SULFATE ION, ... (8 entities in total)
Functional Keywords	tnks2, artd6, inhibitor, parp5b, adp-ribosyltransferase, transferase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	55855.62
Authors	Nkizinkiko, Y.,Haikarainen, T.,Lehtio, L. (deposition date: 2017-04-26, release date: 2017-11-29, Last modification date: 2024-01-17)
Primary citation	Anumala, U.R.,Waaler, J.,Nkizinkiko, Y.,Ignatev, A.,Lazarow, K.,Lindemann, P.,Olsen, P.A.,Murthy, S.,Obaji, E.,Majouga, A.G.,Leonov, S.,von Kries, J.P.,Lehtio, L.,Krauss, S.,Nazare, M. Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach. J. Med. Chem., 60:10013-10025, 2017 Cited by PubMed: 29155568 DOI: 10.1021/acs.jmedchem.7b00883 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation