5NSP
Crystal structure of TNKS2 in complex with OD334
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, B) | Tankyrase-2 | polymer | 191 | 21824.5 | 2 | UniProt (Q9H2K2) Pfam (PF00644) | Homo sapiens (Human) | TANK2,ADP-ribosyltransferase diphtheria toxin-like 6,ARTD6,Poly [ADP-ribose] polymerase 5B,TNKS-2,TRF1-interacting ankyrin-related ADP-ribose polymerase 2,Tankyrase II,Tankyrase-like protein,Tankyrase-related protein |
| 2 | B, D (C, D) | Tankyrase-2 | polymer | 49 | 5493.2 | 2 | UniProt (Q9H2K2) | Homo sapiens (Human) | TANK2,ADP-ribosyltransferase diphtheria toxin-like 6,ARTD6,Poly [ADP-ribose] polymerase 5B,TNKS-2,TRF1-interacting ankyrin-related ADP-ribose polymerase 2,Tankyrase II,Tankyrase-like protein,Tankyrase-related protein |
| 3 | E, J (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | F, H, K, L (A, C, B) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 5 | G, N (A, B) | BICARBONATE ION | non-polymer | 61.0 | 2 | Chemie (BCT) | |||
| 6 | I (C) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 7 | M (B) | 1-[4-[4-(2-chlorophenyl)-5-pyrimidin-4-yl-1,2,4-triazol-3-yl]phenyl]-2-oxidanylidene-3~{H}-benzimidazole-5-carbonitrile | non-polymer | 490.9 | 1 | Chemie (97E) | |||
| 8 | O, P, Q, R (A, C, B, D) | water | water | 18.0 | 90 | Chemie (HOH) |
Sequence modifications
A, B: 946 - 1113 (UniProt: Q9H2K2)
| PDB | External Database | Details |
|---|---|---|
| Met 923 | - | initiating methionine |
| His 924 | - | expression tag |
| His 925 | - | expression tag |
| His 926 | - | expression tag |
| His 927 | - | expression tag |
| His 928 | - | expression tag |
| His 929 | - | expression tag |
| Ser 930 | - | expression tag |
| Ser 931 | - | expression tag |
| Gly 932 | - | expression tag |
| Val 933 | - | expression tag |
| Asp 934 | - | expression tag |
| Leu 935 | - | expression tag |
| Gly 936 | - | expression tag |
| Thr 937 | - | expression tag |
| Glu 938 | - | expression tag |
| Asn 939 | - | expression tag |
| Leu 940 | - | expression tag |
| Tyr 941 | - | expression tag |
| Phe 942 | - | expression tag |
| Gln 943 | - | expression tag |
| Ser 944 | - | expression tag |
| Met 945 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 54635.5 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 1220.1 | |
| All* | Total formula weight | 55855.6 |
